Myelin pp 265-279 | Cite as

Therapeutic Strategies for Oligodendrocyte-Mediated Remyelination

  • Toru OgataEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1190)


Given recent progress in our understanding of oligodendrocyte biology, significant attention has been directed toward cell therapy for myelin repair and remyelination. This trend has been reinforced by findings about the importance of white matter lesions in a variety of central nervous system (CNS) diseases, including demyelinating diseases as well as brain or spinal cord trauma and degenerative disorders such as Alzheimer’s disease. Remyelination strategies include the implementation of myelin forming cells and the surrounding conditions and pathological disease context. Successful remyelination requires proper number of cells at the required location and subsequent maturation. Those processes involve variety of molecules, related to oligodendrocyte development or inflammation in the lesion. Understanding and manipulation of the functions of those molecules may improve the outcome of the cell therapies toward remyelination. Furthermore, the development of monitoring method for myelination is also anticipated to evaluate the effects of therapeutic interventions.


Transplantation Endogenous progenitors Naked axon Inflammation Pharmacological intervention Biomarkers Diffusion tensor imaging 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Rehabilitation for the Movement FunctionsResearch Institute, National Rehabilitation CenterTokorozawaJapan

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