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Immunotherapy for Spondyloarthritis (SpA)

  • Jiao Sun
  • Hiroki HayashiEmail author
Chapter

Abstract

Spondyloarthritis (SpA) is an umbrella term for chronic inflammatory conditions that affect the joints and entheses (the region of attachment between ligaments or tendons and bones) at the sacroiliac region and spine, negatively impacting the patient’s daily life. Because human leukocyte antigen (HLA)-B27, a class I surface antigen encoded in the major histocompatibility complex (MHC), was identified as a strong genetic risk factor, several major theories for the pathological mechanisms have been proposed based on in vitro and translational studies. Additionally, emerging lines of evidence over the last decade suggest that the IL-23/IL-17 axis has a critical role (roles) in the pathology of SpA. Recently, molecular immunotherapy using antibodies has been studied and developed as a therapeutic option to treat SpA. This chapter describes antibody-based immunotherapies targeting arthritogenic inflammatory pathways based on proposed HLA-B27-related mechanisms.

Keywords

HLA-B27 Autoimmune disorder Endoplasmic reticulum (ER) Unfolded protein reaction (UPR) IL-17A IL-23 TNF-α 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Health Development and Medicine, School of MedicineOsaka UniversitySuita, OsakaJapan

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