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Strategies for Disruption of Biofilm Formation Ability and Intricate Quorum Sensing Networks in Aquaculture Vibrio Pathogens

  • Pallaval Veera BramhachariEmail author
  • A. M. V. N. Prathyusha
  • Ganugula Mohana Sheela
  • Neelapu Nageswara Rao Reddy
  • Chanda Vikrant Berde
  • N. M. Yugandhar
Chapter

Abstract

Vibriosis is a serious disease problem in Indian aquaculture. In the past few years, disease problem particularly caused by Vibrio harveyi has been severe in hatcheries, and many units were shut down due to resistance against multiple antibiotics. Since two decades, antibiotics are widely used in aquaculture if bacterial infections are serious. Due to indiscriminate use of antibiotics, Vibrio sp. acquired resistance against multiple antibiotics. Moreover, recently, increasing literature clearly emphasized that antimicrobial-resistant (AMR) genes are transferred to human pathogens. Pertinantly, the quest for finding alternative methods to control multiple antibiotic-resistant vibrios is of utmost priority to have sustainable development in aquaculture. One such alternative and promising method is interruption of bacterial cell-to-cell communication, called quorum sensing (QS). The QS system of V. harveyi comprises of four parallel systems that converge onto a single regulatory pathway, which in turn regulates a number of virulence genes required by the V. harveyi for its pathogenesis. Several studies reported that disruption of QS by enzymatic or chemical inactivation in V. harveyi is triumphant in controlling vibriosis, with some selective pressure for evolution of resistance.

Keywords

Aquaculture Antibiotics Antimicrobial-resistant (AMR) genes Quorum sensing Quorum quenching 

Notes

Acknowledgments

Dr. Bramhachari and colleagues are grateful to Krishna University, Machilipatnam for the extended support.

Conflict of Interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Pallaval Veera Bramhachari
    • 1
    Email author
  • A. M. V. N. Prathyusha
    • 1
  • Ganugula Mohana Sheela
    • 1
  • Neelapu Nageswara Rao Reddy
    • 2
  • Chanda Vikrant Berde
    • 3
  • N. M. Yugandhar
    • 4
  1. 1.Department of BiotechnologyKrishna UniversityMachilipatnamIndia
  2. 2.Department of Biochemistry and Bioinformatics, Institute of ScienceGandhi Institute of Technology and Management (GITAM) (Deemed-to-be University)VisakhapatnamIndia
  3. 3.Department of MicrobiologyGogate Jogalekar CollegeRatnagiriIndia
  4. 4.Department of Chemical EngineeringAndhra UniversityVisakhapatnamIndia

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