Exosomes: Mediators and Therapeutic Targets of Diabetes and Pancreatic Cancer

  • Deepak KGK
  • Rama Rao MallaEmail author


Exosomes are nanoscale extracellular vesicles secreted by exocytosis and affect both physiological and pathological mechanisms. Exosomes are important mediators and therapeutic targets of diabetes mellitus and pancreatic cancer owing to their role in controlling β-cell mass and insulin signaling. Early diagnosis of diabetes and pancreatic cancer can remarkably expand therapeutic approaches and overall survival. Further, identification of biomarkers for predicting the risk of diabetes and pancreatic cancer development and monitoring of their progression to disease state could be useful in envisaging possible complications along with prevention and treatment. Recently, exosomes are recognized as apparent facilitators of intercellular communication. They are reported as novel source of potential biomarkers. Current knowledge on exosome content can further aid in the development of potential markers for diagnosis and prognosis of diabetes and pancreatic cancer and also for discovery of novel therapeutic targets. This chapter covers the current updates on the role of exosomes in types 1 and 2 diabetes as well as pancreatic cancer. The later sections cover the role of exosome in diagnosis, drug delivery, and treatment of diabetes and pancreatic cancer along with their future prospects.


Apoptosis Biomarkers Diabetes Exosomes MicroRNA and pancreatic cancer 



Adipose-derived stem cells


Cerebrospinal fluid


Dendritic cells


Latent autoimmune diabetes


Monogenic maturity onset diabetes


Mesenchymal stem cell

PP cells

Pancreatic polypeptide cells


Resistance to insulin


Type I diabetes


Type II diabetes


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Cancer Biology Lab, Department of Biochemistry and Bioinformatics, GISGITAM (Deemed to be University)VisakhapatnamIndia
  2. 2.Department of Biochemistry and Bioinformatics, GISGITAM (Deemed to be University)VisakhapatnamIndia

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