Role of NADPH Oxidase-Induced Oxidative Stress in Matrix Metalloprotease-Mediated Lung Diseases

  • Jaganmay Sarkar
  • Tapati Chakraborti
  • Sajal ChakrabortiEmail author


Activation of proteases is known to dysregulate the homeostasis of lung metabolomics and thereby triggers a variety of lung diseases such as chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS) and pulmonary hypertension (PH). Among proteases, matrix metalloprotease (MMP) plays a critical role in regulating the turnover (degradation and synthesis) of extracellular matrix (ECM). MMPs facilitate cell migration by modulating production of cytokines and other signaling molecules, which are involved in the pathogenesis of lung diseases. Under normal condition, proteases are controlled by endogenous antiproteases. For example, MMPs are regulated endogenously by their inhibitors, TIMPs. Agonists induced imbalance of MMP-TIMP results in MMP activation. Oxidative stress by modulating inflammatory signaling targets triggers activation of MMPs and thereby initiates the progression of lung diseases. This suggests that MMP inhibition is an attractive therapeutic strategy to ameliorate oxidant-induced lung diseases.


NADPH oxidase Superoxide Metalloproteases Antiproteases Metabolomics 



Financial assistance from the Council of Scientific and Industrial Research (CSIR), New Delhi, is greatly acknowledged.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Jaganmay Sarkar
    • 1
  • Tapati Chakraborti
    • 1
  • Sajal Chakraborti
    • 1
    Email author
  1. 1.Department of Biochemistry and BiophysicsUniversity of KalyaniKalyaniIndia

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