Advances in Molecular and Circuitry Mechanisms of Depressive Disorder—A Focus on Lateral Habenula
Depression is a devastating disorder with a combination of diverse symptoms such as low self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort without a clear cause. Depression has been suggested to be the result of maladaptive changes in specific brain circuits. Recently, the lateral habenula (LHb) has emerged as a key brain region in the pathophysiology of depression. Increasing evidence from rodent, nonhuman primate, and human studies indicates that the aberrant activity of the LHb is associated with depressive symptoms such as helplessness, anhedonia, and excessive negative focus. Revealing the molecular, cellular, and circuit properties of the LHb will help explain how abnormalities in LHb activity are linked to depressive disorders and shed light on developing novel strategies for depression treatment.
KeywordsDepression Lateral habenula LHb circuits Novel antidepressant treatments
This chapter was modified from the paper reported by our group in “current opinion in neurobiology” journal (Yang, Y. et al. (2018) Lateral habenula in the pathophysiology of depression. Curr. Opin. Neurobiol. 48, 90–96). The related contents are reused with permission.
This work was supported by the Natural Science Foundation of China (#91432108, #31225010 and #81527901) and 111 projects to H.H.
Conflict of Interest Statement
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