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Antiseptics and Local Antibiotics

  • Vibhakar Vachhrajani
  • Payal Khakhkhar
Chapter

Abstract

Mercurochrome, acryflavin, chloroxylenol, chlorhexidine are no more used as antiseptics for dressings. Iodine preparations and silver preparations are routinely used dressing materials. Octenidine dihydrochloride, PHMB, and HOCl are good antiseptics available in the market. Antiseptics are available in liquid form, ointment and cream form, and in combination with foam and hydrocolloid dressings. Other than silver preparations, antiseptics need once or twice a day applications. Antiseptic should not be used in healthy and healing wounds.

References

  1. 1.
    Digison MB. A review of anti-septic agents for pre-operative skin preparation. Plast Surg Nurs. 2007;27(4):185–9.CrossRefGoogle Scholar
  2. 2.
    Ascenzi JM. Chloroxylenol: an old-new antimicrobial. In: Handbook of disinfectants and antiseptics. New York: M. Dekker; 1996. ISBN 978-0-8247-9524-5. Archived.Google Scholar
  3. 3.
    British Pharmacopoeia. Compound benzoin tincture. United States Pharmacopeia, USP29-NF24; 2006.
  4. 4.
    Wascher RA, Barcia PJ. Tincture of benzoin: clinical and microbiological implications of reusable containers. Mil Med. 1996;161(3):143–5.. PMID 8637641CrossRefGoogle Scholar
  5. 5.
    Lawrence JC. The use of iodine as an antiseptics agent. J Wound Care. 1998;7:421–15.CrossRefGoogle Scholar
  6. 6.
    Higgins DG. POvidone iodine: the tamed iodine. Chemist Druggist. 1975;30:274–5.Google Scholar
  7. 7.
    Bianchi J. Cadexomer iodine in the treatment of venous leg ulcers: what is the evidence. J Wound Care. 2001;10:225–9.CrossRefGoogle Scholar
  8. 8.
    Hansson C, Cadexomer Iodine Study Group. The effect of cadexomer iodine paste in the treatment of venous leg ulcers compared with hydrocolloid dressing and paraffin gauze dressing. Int J Dermatol. 1998;37:390–6.CrossRefGoogle Scholar
  9. 9.
    Michanek A, Hansson C, Berg G, Maneskold Claes A. Iodine induced hyperthyroidism after cadexomer iodine treatment of leg ulcers. Lakartidningen. 1998;9:5755–6.Google Scholar
  10. 10.
    Holloway GA, Johansen KH, Barnes RW, Pierce GE. Multicenter trial of cadexomer iodine to treat venous stasis ulcers. West J Med. 1989;15:35–8.Google Scholar
  11. 11.
    Apelqvist J, Rangnarson Tennvall G. Cavity Foot ulcers in diabetic patients: a comparative study of cadexomer iodine and standard treatment. An economic analysis alongside a clinical trial. Acta Dermatol Venereol. 1996:76231–5.Google Scholar
  12. 12.
    Klasen HJ. Historical review of the use of silver in the treatment of burns, 1: early use. Burns. 2000;26:117–30.CrossRefGoogle Scholar
  13. 13.
    Dowsett C. The use of silver based dressings in wound care. Nurs Stand. 2004;19:56–60.CrossRefGoogle Scholar
  14. 14.
    Lansdown ABG, Williams A, Chandler S, Benfield S. Silver absorption and antibacterial efficacy of silver dressings. J Wound Care. 2005;14:155–60.CrossRefGoogle Scholar
  15. 15.
    Rayman G, Rayman A, Baker NR, et al. Sustained silver dressing in treatment of diabetic foot ulcers. Br J Nurs. 2005;14:109–14.CrossRefGoogle Scholar
  16. 16.
    Jude EB, Apelqvist J, Spraul M, et al. Prospective randomized controlled study of hydrofiber dressing containing ionic silver or calcium alginate dressings non ischemic diabetic foot ulcers. Diabet Med. 2007;24:280–8.CrossRefGoogle Scholar
  17. 17.
    Landa-Solis C, Gonzalez-Espinosa D, Guzman-soriano B, Snyder M, Reyes-Teran G, Torres K, Gutierrez AA. Microcyn: a novel super-oxidised water with neutral pH and disinfectant activity. J Hosp Infect. 2005;61:291–9.CrossRefGoogle Scholar
  18. 18.
    Stewart PS, Rayner J, Roe F, Rees WM. Biofilm penetration and disinfection efficacy of alkaline hypo-chlorite and chlorosulfamates. J Appl Microbiol. 2001;91:525–32.CrossRefGoogle Scholar
  19. 19.
    Tanaka H, Hirakata Y, Kaku M, Yoshida R, Takemura H Mizukane R, Ishida K, Tomono K, Koga H, Kohno S, et al. Antimicrobial activity of super oxidized water. J Hosp Infect. 1996;34:43–9.CrossRefGoogle Scholar
  20. 20.
    McLaren AC. Alternative materials to acrylic bone cement for delivery of depot antibiotics in orthopaedic infections. Clin Orthop Relat Res. 2004;427:101–6.CrossRefGoogle Scholar
  21. 21.
    Mendel V, Simanowski HJ, Scholz HC, Heymann H. Therapy with gentamicin-PMMA beads, gentamicin-collagen sponge, and cefazolin for experimental osteomyelitis due to Staphylococcus aureus in rats. Arch Orthop Trauma Surg. 2005;125:363–8.CrossRefGoogle Scholar
  22. 22.
    Nelson CL, McLaren SG, Skinner RA, et al. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res. 2002;20:643–7.CrossRefGoogle Scholar
  23. 23.
    Silverman LD, Lukashova L, Herman OT, Lane JM, Boskey AL. Release of gentamicin from a tricalcium phosphate bone implant. J Orthop Res. 2007;25:23–9.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Vibhakar Vachhrajani
    • 1
  • Payal Khakhkhar
    • 1
  1. 1.Diabetic foot and wound managementVijay Vachhrajani Memorial Hospital RajkotIndia

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