Recrudescence and Reinfection After H. pylori Eradication Treatment

  • Nayoung Kim


Helicobacter pylori (H. pylori) recurrence can be classified into two classes: recrudescence and reinfection. Recrudescence is a recurrence of the same infection after antimicrobial treatment, which occurs as first-year relapses. On the other hand, reinfection is defined as a state wherein a patient becomes infected with a new H. pylori strain after the patient went through successful eradication therapy. DNA fingerprinting technique is utilized to distinguish between recrudescence and reinfection. However, this technique cannot be done for every single analysis, so numerous researches define reinfection as a H. pylori-positive state after 12 months of H. pylori-negative condition during a monitoring period once an eradication treatment is over. In terms of H. pylori reinfection, worldwide annual reinfection rate is reported to be 0–23.4 % on adults and 1.9–9.6 % on pediatrics, but the rates are less than 1 % in the developed countries, while they are high among developing nations. The risk factors of this recurrence were noncompliance to the initial therapy, presence of children in the household, male, and low income. H. pylori reinfection rate will further decrease, if socioeconomic condition and public hygiene continue to ameliorate.


Recrudescence Reinfection Helicobacter pylori 


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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  1. 1.Department of Internal MedicineSeoul National University College of Medicine, Seoul National University Bundang HospitalSeongnamSouth Korea

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