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Plasmonic Exosome Biosensors for Medical Diagnostics

  • Agnes T. Reiner
  • Koji Toma
  • Alain R. Brisson
  • Dietmar Pils
  • Wolfgang Knoll
  • Jakub DostalekEmail author
Chapter
Part of the Progress in Optical Science and Photonics book series (POSP, volume 3)

Abstract

This chapter provides an overview of plasmonic biosensor technology for the analysis of extracellular lipid vesicles that hold potential to serve as new type of biomarkers. In particular, it discusses detection of exosomes that are secreted to bodily fluids and become of increasing interest in clinical research. Plasmonic biosensor technology is pushed forward to provide new means for their sensitive and specific detection without the need of specialized laboratories. It offers a versatile optical toolbox for probing various biological species by tightly confined electromagnetic field of surface plasmons. These optical waves originate from collective oscillations of electron charge density at metallic thin films and (nano)structures. This chapter gives an introduction to surface plasmon photonics and its use in direct surface plasmon resonance and in fluorescence spectroscopy-based biosensors. It provides a brief summary of current state-of-the-art in exosome biomarker research and discusses current advances in exosome plasmonic biosensors for medical diagnostics of diseases, in particular cancer.

Keywords

Surface Plasmon Resonance Recipient Cell Lipid Vesicle Extracellular Vesicle Nanoparticle Tracking Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was partially supported by Austrian Science Fund (FWF) through the project ACTIPLAS (P244920-N20) and by Austrian Federal Ministry for Transport, Innovation and Technology (GZ BMVIT-612.166/0001-III/I1/2010) via the International Graduate School Bio-Nano-Tech, a joint Ph.D. program of the University of Natural Resources and Life Sciences Vienna (BOKU), the Austrian Institute of Technology (AIT), and the Nanyang Technological University (NTU).

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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  • Agnes T. Reiner
    • 1
    • 2
  • Koji Toma
    • 3
  • Alain R. Brisson
    • 4
  • Dietmar Pils
    • 5
  • Wolfgang Knoll
    • 1
    • 2
  • Jakub Dostalek
    • 1
    Email author
  1. 1.BioSensor TechnologiesAIT-Austrian Institute of Technology GmbHViennaAustria
  2. 2.Centre for Biomimetic Sensor Science, School of Materials Science and EngineeringNanyang Technological UniversitySingaporeSingapore
  3. 3.Institute of Biomaterials and BioengineeringTokyo Medical and Dental UniversityChiyoda-kuJapan
  4. 4.Molecular Imaging and NanoBioTechnologyUMR-5248-CBMN CNRS-University of Bordeaux-IPBPessacFrance
  5. 5.Department of Obstetrics and Gynecology, Molecular Oncology GroupMedical University of ViennaViennaAustria

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