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New Insights into the Regulatory Role of lncRNA, circRNA, piRNAs, and ceRNAs in Ischemic Stroke

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IschemiRs: MicroRNAs in Ischemic Stroke

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Abstract

The past decade witnessed a paradigm shift of attention from a protein-centric approach to RNA centric approach in understanding the complexity of multi-factorial diseases like ischemic stroke. Thus, marking the beginning of a new class of non-protein-coding genes, exemplified by the intense research on microRNA, in human physiology and disease. However, microRNAs are just the beginning of a whole new world of non-coding RNAs (ncRNAs), with unexplored limitless functionalities. These ncRNAs are emerging as prominent regulators of gene expression and as a potential therapeutic modality in various disease pathologies including but not limited to cancer, neurological, and cardiovascular diseases. Here, we look upon some relevant ncRNAs: long non-coding RNAs (lncRNAs), PIWI-interacting RNAs (piRNAs), circular RNAs (circRNAs), and others, their molecular interaction and therapeutic potential in the context of stroke pathology.

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Authors and Affiliations

  1. School of Biotechnology, National Institute of Technology Calicut, Calicut, India

    Rajanikant G. K. & Gokul Surendran

  2. NeuroDiderot, Inserm, Université de Paris, Paris, France

    Pierre Gressens & Cindy Bokobza

  3. Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition INSERM 1172, Lille, France

    Sreekala S. Nampoothiri

Authors
  1. Rajanikant G. K.
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  2. Pierre Gressens
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  3. Sreekala S. Nampoothiri
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  4. Gokul Surendran
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  5. Cindy Bokobza
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G. K., R., Gressens, P., Nampoothiri, S.S., Surendran, G., Bokobza, C. (2020). New Insights into the Regulatory Role of lncRNA, circRNA, piRNAs, and ceRNAs in Ischemic Stroke. In: IschemiRs: MicroRNAs in Ischemic Stroke. Springer, Singapore. https://doi.org/10.1007/978-981-15-4798-0_9

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