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microRNA Regulation of Ischemic Stroke Inflammatory and Immune Response

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IschemiRs: MicroRNAs in Ischemic Stroke

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Abstract

Ischemic stroke is one leading cause of death worldwide, and inflammation has been extensively associated with its ontogeny and subsequent brain lesions. MicroRNAs (miRs) are non-coding RNA molecules that specifically repress gene expression post-transcriptionally. Several miRs have been correlated with innate immune response, and evidence accumulating suggests miRs regulatory role during stroke-related neuroinflammation. The use of miRs as a potential neuroprotective target for ischemic stroke is increasingly being considered as a result of this build-up knowledge. In this chapter, our communication focuses on the identification of miRs linked to neuroinflammatory ontogeny associated with ischemic stroke.

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Authors and Affiliations

  1. School of Biotechnology, National Institute of Technology Calicut, Calicut, India

    Rajanikant G. K. & Gokul Surendran

  2. NeuroDiderot, Inserm, Université de Paris, Paris, France

    Pierre Gressens & Cindy Bokobza

  3. Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition INSERM 1172, Lille, France

    Sreekala S. Nampoothiri

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  1. Rajanikant G. K.
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  2. Pierre Gressens
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  3. Sreekala S. Nampoothiri
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  4. Gokul Surendran
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  5. Cindy Bokobza
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Correspondence to Rajanikant G. K. .

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G. K., R., Gressens, P., Nampoothiri, S.S., Surendran, G., Bokobza, C. (2020). microRNA Regulation of Ischemic Stroke Inflammatory and Immune Response. In: IschemiRs: MicroRNAs in Ischemic Stroke. Springer, Singapore. https://doi.org/10.1007/978-981-15-4798-0_4

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