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Ischemic Stroke: An Imperative Need for Effective Therapy

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IschemiRs: MicroRNAs in Ischemic Stroke

Abstract

While it is currently estimated that stroke causes eight million annual deaths worldwide, the death rate only gives a first account of the overall burden of disease. Ischemic stroke is caused by the blockade or occlusion of the cerebral artery compromising blood supply and energy flow to the brain. The likelihood of restoration of blood flow depends on the extent of thrombosis within the cerebral artery. Thrombolysis is currently coupled with endovascular approaches for the removal and dissolution of occlusive thrombus. This chapter provides an overview of the current thrombolytic and endovascular treatment approaches for post-stroke care along with the emerging neuroprotective agents that are lost in translation.

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Authors and Affiliations

  1. School of Biotechnology, National Institute of Technology Calicut, Calicut, India

    Rajanikant G. K. & Gokul Surendran

  2. NeuroDiderot, Inserm, Université de Paris, Paris, France

    Pierre Gressens & Cindy Bokobza

  3. Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition INSERM 1172, Lille, France

    Sreekala S. Nampoothiri

Authors
  1. Rajanikant G. K.
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  2. Pierre Gressens
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  3. Sreekala S. Nampoothiri
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  4. Gokul Surendran
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  5. Cindy Bokobza
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Correspondence to Rajanikant G. K. .

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G. K., R., Gressens, P., Nampoothiri, S.S., Surendran, G., Bokobza, C. (2020). Ischemic Stroke: An Imperative Need for Effective Therapy. In: IschemiRs: MicroRNAs in Ischemic Stroke. Springer, Singapore. https://doi.org/10.1007/978-981-15-4798-0_2

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