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Single Cell Sequencing: A New Dimension in Cancer Diagnosis and Treatment

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Single-cell Sequencing and Methylation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1255))

Abstract

Cancer is one of the leading causes of death worldwide and well known for its complexity. Cancer cells within the same tumor or from different tumors are highly heterogeneous. Furthermore, stromal and immune cells within tumor microenvironment interact with cancer cells to play important roles in how tumors progress and respond to different treatments. Recent advances in single cell technologies, especially massively parallel single cell sequencing, have made it possible to analyze cancer cells and cells in its tumor microenvironment in parallel with unprecedented high resolution. In this chapter, we will review recent developments in single cell sequencing technologies and their applications in cancer research. We will also explain how insights generated from single cell sequencing can be used to develop novel diagnostic and therapeutic approaches to conquer cancer.

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Acknowledgement

Disclosure: Nan Fang is Founder and Chief Executive Officer of Singleron Biotechnologies, a company that develops single-cell sequencing products. Jue Fan and Jingwen Fang are employees at Singleron Biotechnologies.

Author information

Author notes

  1. Fengying Wu and Jue Fan contributed equally to this work.

Authors and Affiliations

  1. Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China

    Fengying Wu

  2. Singleron Biotechnologies, Nanjing, Jiangsu, China

    Jue Fan, Jingwen Fang & Nan Fang

  3. Institute for Pathology, University Hospital of Cologne, Cologne, Germany

    Priya S. Dalvi & Margarete Odenthal

  4. Centre for Molecular Medicine Cologne, University of Cologne (UoC), Cologne, Germany

    Priya S. Dalvi & Margarete Odenthal

  5. Department of Pathology, Anhui Medical University, Hefei, Anhui, China

    Nan Fang

Authors
  1. Fengying Wu
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  2. Jue Fan
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  3. Jingwen Fang
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  4. Priya S. Dalvi
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  5. Margarete Odenthal
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  6. Nan Fang
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Corresponding author

Correspondence to Nan Fang .

Editor information

Editors and Affiliations

  1. Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, Shanghai, China

    Buwei Yu

  2. Department of Anesthesiology and Perioperative Medicine, Center of Clinical Single-Cell Biomedicine, Henan Provincial People’s Hospital, Zhengzhou, University People’s Hospital, Henan University People’s Hospital, Zhengzhou, P.R., China

    Jiaqiang Zhang

  3. 2nd Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China

    Yiming Zeng

  4. Centre for Single Cell Biomedicine, Henan Provincial People’s Hospital, Zhengzhou, Henan, China

    Li Li

  5. Zhongshan Hospital, Fudan University, Shanghai, Shanghai, China

    Xiangdong Wang

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Wu, F., Fan, J., Fang, J., Dalvi, P.S., Odenthal, M., Fang, N. (2020). Single Cell Sequencing: A New Dimension in Cancer Diagnosis and Treatment. In: Yu, B., Zhang, J., Zeng, Y., Li, L., Wang, X. (eds) Single-cell Sequencing and Methylation. Advances in Experimental Medicine and Biology, vol 1255. Springer, Singapore. https://doi.org/10.1007/978-981-15-4494-1_9

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