Advertisement

Bioprospecting and Biotechnological Applications of Microbial Endophytes

  • Sneh Sharma
  • Varsha Rani
  • Raj Saini
  • Madan L. VermaEmail author
Chapter
  • 38 Downloads
Part of the Microorganisms for Sustainability book series (MICRO, volume 22)

Abstract

Endophytes are a family of microbes which grow inter/intracellularly in the tissues of higher plants without causing any kind of harm to the host plant in which they reside. Endophytic microbes are representing a potential source of natural bioactive compounds which are highly useful in agriculture, medicine and industries, such as antioxidants, anticancerous agents, antidiabetic, antibiotics, biological control agents and others. A broad variety of bioactive secondary metabolites are being provided by the endophytes with unique structural properties, including steroids, phenolic acids, alkaloids, flavonoids, benzopyranones, terpenoids, quinines, xanthones, tetralones, etc. These bioactive secondary metabolites find a wider range of applications as immunosuppressants, antibiotics, agrochemicals, antioxidants, anticancerous agents and antiparasitic. Novel antimicrobial metabolite discovery from the endophytes is an alternative way to overcome the problem of drug resistance in human and plant pathogens. Novel compound production via the process of biotransformation by endophytes is an interesting phenomenon, providing a number of advantages over the chemical synthesis as well as enhancing the productivity of the desired products.

Endophytes have the ability to produce similar secondary bioactive metabolites as produced by their host plants, thus promoting good yield and growth, and enable host plant to tolerate the abiotic as well as biotic stress conditions and disease resistance. This field is attracting a lot of interest, and therefore it can be utilised for novel natural products in medicinal, food and agricultural industries. This chapter is dealing with the endophytic microorganisms, their applications and phytochemicals produced via endophytes.

Keywords

Microorganisms Plants Interactions Biotransformation Metabolites Bioactive 

References

  1. Abdalla MA, McGaw LJ (2018) Bioprospecting of South African plants as a unique resource for bioactive endophytic microbes. Front Pharmacol 9:456.  https://doi.org/10.3389/fphar.2018.00456CrossRefPubMedPubMedCentralGoogle Scholar
  2. Adhikari P, Pandey A (2018) Diversity of endophytic fungi associated with Himalayan Yew roots. Proc Himalayan Res Consort 1:1–9. https://www.researchgate.net/publication/332170697_Diversity_of_Endophytic_Fungi_Associated_with_Himalayan_Yew_Taxus_wallichiana_Zucc_Roots/citationsGoogle Scholar
  3. Adhikari P, Pandey A (2019) Phosphate solubilization potential of endophytic fungi isolated from Taxus wallichiana Zucc. roots. Rhizosphere 9:2–9.  https://doi.org/10.1016/j.rhisph.2018.11.002CrossRefGoogle Scholar
  4. Afridi MS, Sumaira A, Mahmood T, Salam A, Mukhtar T, Mehmood S, Ali J, Khatoon Z, Bibi M, Javed Sultan MT, Chaudhary HJ (2019) Induction of tolerance to salinity in wheat genotypes by plant growth promoting endophytes: Involvement of ACC deaminase and antioxidant enzymes. Plant Physiol Biochem 139:569–577.  https://doi.org/10.1016/j.plaphy.2019.03.041CrossRefPubMedGoogle Scholar
  5. Agrawal T, Kotasthane AS (2012) Chitinolytic assay of indigenous Trichoderma isolates collected from different geographical locations of Chhattisgarh in Central India. Springer Plus 1:73.  https://doi.org/10.1186/2193-1801-1-73CrossRefPubMedGoogle Scholar
  6. Ahmedullah M and Nayar MP (1999) Red data book of Indian plants (Peninsular India). Botanical Survey of India, Calcutta. Vol 4. http://agris.fao.org/agris-search/search.do?recordID=US201300602313
  7. Ali S, Isaacson J, Kroner Y, Saldias S, Kandasamy S, Lazarovits G (2018) Corn sap bacterial endophytes and their potential in plant growth-promotion. Environ Sustain 1:341–355.  https://doi.org/10.1007/s42398-018-00030-4CrossRefGoogle Scholar
  8. Ali S, Khan SA, Hamayun M, Iqbal A, Khan A, Hussain A, Shah M (2019) Endophytic fungi from Caralluma acutangula can secrete plant growth promoting enzymes. Fresenius Environ Bull 28:2688–2696. https://www.researchgate.net/publication/332291226Google Scholar
  9. Alsheikh M, Saleh AI, Mohammad AI, Dosari S, Abdul M, Maged Abdel-Kader S (2009) Evaluation of the hepatoprotective effect of fumaria parviflora and Momordica balsamina from Saudi folk medicine against experimentally induced liver injury in rats. Res J Med Plant 3:9–15.  https://doi.org/10.3923/rjmp.2009.9.15CrossRefGoogle Scholar
  10. Amna T, Puri SC, Verma V, Sharma JP, Khajuria RK, Musarrat J, Spiteller M, Qazi GN (2006) Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin. Can J Microbiol 52:189–196.  https://doi.org/10.1139/w05-122CrossRefPubMedGoogle Scholar
  11. Andreolli M, Zapparoli G, Angelini E, Lucchetta G, Lampis S, Vallini G (2019) Pseudomonas protegens MP12: a plant growth-promoting endophytic bacterium with broad-spectrum antifungal activity against grapevine phytopathogens. Microbiol Res 219:123–131.  https://doi.org/10.1016/j.micres.2018.11.003CrossRefPubMedGoogle Scholar
  12. Ballio A, Bossa F, DiGiogio P, Ferranti P, Paci M, Pucci P, Scaloni A, Segre A, Strobel GA (1994) Structure of the pseudomycins, new lipodepsipeptides produced by Pseudomonas syringae MSU 16H. FEBS Lett 355:96–100.  https://doi.org/10.1016/0014-5793(94)01179-6.CrossRefPubMedGoogle Scholar
  13. Baram-Pinto D, Shukla S, Perkas N, Gedanken A, Sarid R (2009) Inhibition of herpes simplex virus type 1 infection by silver nanoparticles capped with mercaptoethane sulfonate. Bioconjug Chem 20:1497–1502.  https://doi.org/10.1021/bc900215bCrossRefPubMedGoogle Scholar
  14. Barka EA, Vatsa P, Sanchez L, Gaveau-Vaillant N, Jacquard C, Klenk HP (2016) Taxonomy, physiology, and natural products of Actinobacteria. Microbiol Mol Biol Rev 80:1–43.  https://doi.org/10.1128/MMBR.00019-15CrossRefPubMedGoogle Scholar
  15. Berdy J (2012) Thoughts and facts about antibiotics: where were now and where were heading. J Antibiot 65:385–395.  https://doi.org/10.1038/ja.2012.27CrossRefPubMedGoogle Scholar
  16. Berkodia M, Joshi U, Rami NV, Wati L (2018) Endophytes: a hidden treasure inside plant. Int J Chem Stud 6:1660–1665Google Scholar
  17. Bezerra JDP, Nascimento CCF, Barbosa R do N, da Silva DCV, Svedese VM, Silva-Nogueira EB, Gomes BS, Paiva LM, Souza-Motta CM (2015) Endophytic fungi from medicinal plant Bauhinia forficata: Diversity and biotechnological potential. Braz J Microbiol 46(1):49–57.  https://doi.org/10.1590/S1517-838246120130657CrossRefPubMedPubMedCentralGoogle Scholar
  18. Bhardwaj A, Agrawal P (2014) A review fungal endophytes: as a storehouse of bioactive compound. World. J Pharm Pharm Sci 3:228–237. www.wjpps.comGoogle Scholar
  19. Borel JF, Kis ZL (1991) The discovery and development of cyclosporine. Transplant Proc 23:1867–1874.  https://doi.org/10.1007/978-1-4615-9846-6_2CrossRefPubMedGoogle Scholar
  20. Borges KB, Borges WDS, Pupo MT, Bonato PS (2007) Endophytic fungi as models for the stereoselective biotransformation of thioridazine. Appl Microbiol Biotechnol 77:669–674.  https://doi.org/10.1007/s00253-007-1171-xCrossRefPubMedGoogle Scholar
  21. Cardoso-Filho JA (2018) Endophytic microbes as a novel source for producing anticancer compounds as multidrug resistance modulators. In: Akhtar M, Swamy M (eds) Anticancer plants: natural products and biotechnological implements. Springer, Singapore, pp 343–381.  https://doi.org/10.1007/978-981-10-8064-7_15CrossRefGoogle Scholar
  22. Castillo UF, Strobel GA, Ford EJ, Hess WM, Porter H, Jensen JB, Albert H, Robinson R, Condron MA, Teplow DB et al (2002) Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigricans. Microbiologica 148:2675–2685.  https://doi.org/10.1099/00221287-148-9-2675CrossRefGoogle Scholar
  23. Castillo U, Harper JK, Strobel GA, Sears J, Alesi K, Ford E, Lin J, Hunter M, Maranta M, Ge H, Yaver D, Jensen JB, Porter H, Robison R, Millar D, Hess WM, Condron M, Teplow D (2003) Kakadumycins, novel antibiotics from Streptomyces sp. NRRL 30566, an endophyte of Grevillea pteridifolia. FEMS Lett 224:183–190.  https://doi.org/10.1016/S0378-1097(03)00426-9CrossRefGoogle Scholar
  24. Chaudhary HS, Soni B, Shrivastava AR, Shrivastava S (2013) Diversity and versatility of actinomycetes and its role in antibiotic production. Int J Pharm Sci 3:S83–S94.  https://doi.org/10.7324/JAPS.2013.38.S14CrossRefGoogle Scholar
  25. Chen YT, Yuan Q, Shan LT, Lin MA, Cheng DQ, Li CY (2013) Antitumor activity of bacterial exopolysaccharides from the endophyte Bacillus amyloliquefaciens sp. isolated from Ophiopogon japonicus. Oncol Lett 5:1787–1792.  https://doi.org/10.3892/ol.2013.1284CrossRefPubMedPubMedCentralGoogle Scholar
  26. Chen L, Shi H, Heng J, Wang D, Bian K (2019a) Antimicrobial, plant growth-promoting and genomic properties of the peanut endophyte Bacillus velezensis LDO2. Microbiol Res 218:41–48.  https://doi.org/10.1016/j.micres.2018.10.002CrossRefPubMedGoogle Scholar
  27. Chen P, Zhang C, Ju X, Xiong Y, Xing K, Qin S (2019b) Community composition and metabolic potential of endophytic actinobacteria from coastal salt marsh plants in Jiangsu, China. Front Microbiol 10:1063.  https://doi.org/10.3389/fmicb.2019.01063CrossRefPubMedPubMedCentralGoogle Scholar
  28. Christhudas IN, Kumar PP, Agastian P (2013) In vitro α-glucosidase inhibition and antioxidative potential of an endophyte species (Streptomyces sp. Loyola UGC) isolated from Datura stramonium L. Curr Microbiol 67(1):69–76.  https://doi.org/10.1007/s00284-013-0329-2CrossRefGoogle Scholar
  29. Christina A, Christapher V, Bhore SJ (2013) Endophytic bacteria as a source of novel antibiotics: an overview. Pharmacogn Rev 7:11–16.  https://doi.org/10.4103/0973-7847.112833CrossRefPubMedPubMedCentralGoogle Scholar
  30. Chutulo EC, Chalanaavar RK (2018) Endophytic microflora and their bioactive compounds from Azadirachta indica: a comprehensive review. J Fungi 4:42.  https://doi.org/10.3390/jof4020042CrossRefGoogle Scholar
  31. Compant S, Samad A, Faist H, Sessitsch A (2019) A review on the plant microbiome: ecology, functions, and emerging trends in microbial application. J Adv Res 19:29–37.  https://doi.org/10.1016/j.jare.2019.03.004CrossRefPubMedPubMedCentralGoogle Scholar
  32. Corrêa RCG, Rhoden SA, Mota TR, Azevedo JL, Pamphile JA (2014) Endophytic fungi: expanding the arsenal of industrial enzyme producers. J Ind Microbiol Biotechnol 41(10):1467–1478.  https://doi.org/10.1007/s10295-014-1496-2CrossRefPubMedGoogle Scholar
  33. da Silva Ribeiro A, Polonio JC, Costa AT, dos Santos CM, Rhoden SA, Azevedo JL, Pamphile JA (2018) Bioprospection of culturable endophytic fungi associated with the ornamental plant Pachystachys lutea. Curr Microbiol 75:588–596.  https://doi.org/10.1007/s00284-017-1421-9CrossRefPubMedGoogle Scholar
  34. Daisy BH, Strobel GA, Castillo U, Ezra D, Sears J, Weaver DK, Runyon JB (2002) Naphthalene, an insect repellent, is produced by Muscodor vitigenus, a novel endophytic fungus. Microbiology 148:3737–3741.  https://doi.org/10.1099/00221287-148-11-3737CrossRefPubMedGoogle Scholar
  35. Danshiitsoodol N, Pinho CA, Matoba Y, Kumagai T, Sugiyama M (2006) The mitomycin C (MMC)-binding protein from MMC producing microorganisms protects from the lethal effect of bleomycin: crystallographic analysis to elucidate the binding mode of the antibiotic to the protein. J Mol Biol 360:398–408.  https://doi.org/10.1016/j.jmb.2006.05.017CrossRefPubMedGoogle Scholar
  36. De Bary A (1866) Morphologie und physiologie der pilze, flechten und myxomyceten. Leipzig: hofmeister’s handbook of physiological. Botany 2:20. https://archive.org/details/bub_gb_-I0NAAAAYAAJ/page/n5Google Scholar
  37. Delgado-García M, Flores-Gallegos AC, Kirchmayr M, Rodríguez JA, Mateos-Díaz JC, Aguilar CN, Muller M, Camacho-Ruíz RM (2019) Bioprospection of proteases from Halobacillus andaensis for bioactive peptide production from fish muscle protein. Electron J Biotechnol 39:52–60.  https://doi.org/10.1016/j.ejbt.2019.03.001CrossRefGoogle Scholar
  38. Demain AL (1981) Industrial microbiology. Science 214:987–994.  https://doi.org/10.1126/science.6946560CrossRefPubMedGoogle Scholar
  39. Ding L, Münch J, Goerls H, Maier A, Fiebig H-H, Lin W-H, Hertweck C (2010) Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte. Bioorg Med Chem Lett 20(22):6685–6687.  https://doi.org/10.1016/j.bmcl.2010.09.010CrossRefPubMedGoogle Scholar
  40. Dorra G, Ines K, Imen BS, Laurent C, Sana A, Olfa T, Pascal C, Thierry J, Ferid L (2018) Purification and characterization of a novel high molecular weight alkaline protease produced by an endophytic Bacillus halotolerans strain CT2. Int J Biol Macromol 111:342–351.  https://doi.org/10.1016/j.ijbiomac.2018.01.024CrossRefPubMedGoogle Scholar
  41. Eevers N, Gielen M, Sánchez-López A, Jaspers S, White JC, Vangronsveld J, Weyens N (2015) Optimization of isolation and cultivation of bacterial endophytes through addition of plant extract to nutrient media. Microb Biotechnol 8(4):707–715.  https://doi.org/10.1111/1751-7915.12291CrossRefPubMedPubMedCentralGoogle Scholar
  42. Ek-Ramos MJ, Gomez-Flores R, Orozco-Flores AA, Rodríguez-Padilla C, González-Ochoa G, Tamez-Guerra P (2019) Bioactive products from plant-endophytic Gram-positive bacteria. Front Microbiol 10:463.  https://doi.org/10.3389/fmicb.2019.00463CrossRefPubMedPubMedCentralGoogle Scholar
  43. Elgorban AM, Abdel-Wahab MA (2018) Natural products of Alternaria sp. an endophytic fungus isolated from Salvadora persica from Saudi Arabia. Saudi J Biol Sci 26:1068–1077.  https://doi.org/10.1016/j.sjbs.2018.04.010CrossRefPubMedPubMedCentralGoogle Scholar
  44. Espinasse S, Gohar M, Lereclus D, Sanchis V (2002) An ABC transporter from Bacillus thuringiensis is essential for beta-exotoxin I production. J Bacteriol 184:5848–5854.  https://doi.org/10.1128/jb.184.21.5848-5854.2002CrossRefPubMedPubMedCentralGoogle Scholar
  45. Ezra D, Castillo UF, Strobel GA, Hess WM, Porter H (2004) Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. MSU-2110 endophytic on Monstera sp. Microbiologica 150:785–793.  https://doi.org/10.1099/mic.0.26645-0CrossRefGoogle Scholar
  46. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Cancer incidence and mortality worldwide: IARC cancer base No. 10 Lyon, France: International Agency for Research on Cancer. Globocan 46:765–781.  https://doi.org/10.1016/j.ejca.2009.12.014CrossRefGoogle Scholar
  47. Ferreira MC, Cantrell CL, Wedge DE, Gonçalves VN, Jacob MR, Khan S, Rosa CA, Rosa LH (2017) Diversity of the endophytic fungi associated with the ancient and narrowly endemic neotropical plant Vellozia gigantea from the endangered Brazilian rupestrian grasslands. Biochem Syst Ecol 71:163–169.  https://doi.org/10.1016/j.bse.2017.02.006CrossRefGoogle Scholar
  48. Findlay J, Bethelezi AS, Li G, Sevek M (1997) Insect toxins from an endophyte fungus from wintergreen. J Nat Prod 60:1214–1215.  https://doi.org/10.1021/np970222jCrossRefGoogle Scholar
  49. Firakova S, Sturdikova M, Muckova M (2007) Bioactive secondary metabolites produced by microorganisms associated with plants. Biologia 62:251–257.  https://doi.org/10.2478/s11756-007-0044-1CrossRefGoogle Scholar
  50. Fouda AH, Hassan SED, Eid AM, Ewais EED (2015) Biotechnological applications of fungal endophytes associated with medicinal plant Asclepias sinaica (Bioss.). Ann Agric Sci 60(1):95–104.  https://doi.org/10.1016/j.aoas.2015.04.001CrossRefGoogle Scholar
  51. Fuchs B, Krischke M, Mueller MJ, Krauss J (2017) Plant age and seasonal timing determine endophyte growth and alkaloid biosynthesis. Fungal Ecol 29):52–58.  https://doi.org/10.1016/j.funeco.2017.06.003CrossRefGoogle Scholar
  52. Gangwar M, Dogra S, Gupta UP, Kharwar RN (2014) Diversity and biopotential of endophytic actinomycetes from three medicinal plants in India. Afr J Microbiol Res 8:184–191.  https://doi.org/10.5897/AJMR2012.2452CrossRefGoogle Scholar
  53. Gao Y, Lu Q, Pu Zang P, Li X, Ji Q, He Z et al (2015) An endophytic bacterium isolated from Panax ginseng CA Meyer enhances growth, reduces morbidity, and stimulates ginsenoside biosynthesis. Phytochem Lett 11:132–138.  https://doi.org/10.1016/j.phytol.2014.12.007CrossRefGoogle Scholar
  54. Gao Z, Zhang B, Liu H, Han J, Zhang Y (2017) Identification of endophytic Bacillus velezensis ZSY-1 strain and antifungal activity of its volatile compounds against Alternaria solani and Botrytis cinerea. Biol Control 105:27–39.  https://doi.org/10.1016/j.biocontrol.2016.11.007CrossRefGoogle Scholar
  55. Garcia A, Rhoden SA, Rubin Filho CJ, Nakamura CV, Pamphile JA (2012) Diversity of foliar endophytic fungi from the medicinal plant Sapindus saponaria L. and their localization by scanning electron microscopy. Biol Res 45(2):139–148.  https://doi.org/10.4067/S0716-97602012000200006CrossRefPubMedGoogle Scholar
  56. Glick BR, Karaturovíc DM, Newell PC (1995) A novel procedure for rapid isolation of plant growth promoting pseudomonads. Can J Microbiol 41:533–536.  https://doi.org/10.1007/s10482-015-0502-7.CrossRefGoogle Scholar
  57. Golinska P, Wypij M, Agarkar G, Rathod D, Dahm H, Rai M (2015) Endophytic actinobacteria of medicinal plants: diversity and bioactivity. Antonie Van Leeuwenhoek 108:267–289.  https://doi.org/10.1007/s10482-015-0502-7CrossRefPubMedPubMedCentralGoogle Scholar
  58. Gond SK, Bergen MS, Torres MS (2015) Endophytic bacillus spp. Produce antifungal lipopeptides and induce host defence gene expression in maize. Microbiol Res 172:79–87.  https://doi.org/10.1016/j.micres.2014.11.004CrossRefPubMedGoogle Scholar
  59. Gouda S, Das G, Sen SK, Shin H-S, Patra JK (2016) Endophytes: a treasure house of bioactive compounds of medicinal importance. Front Microbiol 7:1538.  https://doi.org/10.3389/fmicb.2016.01538CrossRefPubMedPubMedCentralGoogle Scholar
  60. Greenfield M, Pareja R, Ortiz V, Gómez-Jiménez MI, Vega FE, Parsa S (2015) A novel method to scale up fungal endophyte isolations. Biocont Sci Technol 25:1208–1212.  https://doi.org/10.1080/09583157.2015.1033382CrossRefGoogle Scholar
  61. Gu W, Ge HM, Song YC, Ding H, Zhu HL, Zhao XA, Tan RX (2007) Cytotoxic Benzo fluoranthene metabolites from Hypoxylon truncatum IFB-18, an endophyte of Artemisia annua. J Nat Prod 70:114–117.  https://doi.org/10.1021/np0604127CrossRefPubMedGoogle Scholar
  62. Gupta A, Verma H, Singh PP, Singh P, Singh M, Mishra V, Kumar A (2019) Rhizome endophytes: roles and applications in sustainable agriculture. In: Verma S, White J (eds) Seed endophytes. Springer, Cham, pp 405–421.  https://doi.org/10.1007/978-3-030-10504-4_19CrossRefGoogle Scholar
  63. Handayani D, Rivai H, Mulyana R, Suharti N, Rasyid R, Hertiani T (2018) Antimicrobial and cytotoxic activities of endophytic fungi isolated from mangrove plant Sonneratia alba Sm. J Appl Pharmaceut Sci 8:049–053.  https://doi.org/10.7324/JAPS.2018.8207CrossRefGoogle Scholar
  64. Harper JK, Ford EJ, Strobel GA, Arif A, Grant DM, Porco J, Tomer DP, Oneill K (2003) Pestacin: a 1,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antioxidant and antimycotic activities. Tetrahedron 59:2471–2476.  https://doi.org/10.1021/ja010997l.CrossRefGoogle Scholar
  65. Harrison L, Teplow D, Rinaldi M, Strobel GA (1991) Pseudomycins, a family of novel peptides from Pseudomonas syringae, possessing broad spectrum antifungal activity. J Gen Microbiol 137:2857–2865.  https://doi.org/10.1099/00221287-137-12-2857CrossRefPubMedGoogle Scholar
  66. Hassan A, Radwan U, El-Zyat S, El-Sayed M (2018) Desert plant-fungal endophytic association: the beneficial aspects to their hosts. Biolog Forum An Int J 10:138–145. https://www.researchgate.net/publication/325945526Google Scholar
  67. Hollants J, Leroux O, Leliaert F, Decleyre H, De Clerck O, Willems A (2011) Exploration of endophytic bacteria within the siphonous green seaweed Bryopsis (Bryopsidales, Chlorophyta). PLoS One 6:e26458.  https://doi.org/10.1371/journal.pone.0026458CrossRefPubMedPubMedCentralGoogle Scholar
  68. Hong-Thao PH, Mai-Linh NV, Hong-Lien NT, Hieu NV (2016) Biological characteristics and antimicrobial activity of endophytic Streptomyces sp. TQR12-4 isolated from elite Citrus nobilis cultivar Ham Yen of Vietnam. Int J Microbiol 2016:7207818.  https://doi.org/10.1155/2016/7207818CrossRefPubMedPubMedCentralGoogle Scholar
  69. Huang WY, Cai YZ, Xing J, Corke H, Sun M (2007) A potential antioxidant resource: Endophytic fungi from medicinal plants. Econ Bot 61:14–30.  https://doi.org/10.1663/0013-0001(2007)61[14:APAREF]2.0.CO;2CrossRefGoogle Scholar
  70. Huang L, Yuan M, Ao X, Ren A, Zhang H, Yang M (2018) Endophytic fungi specifically introduce novel metabolites into grape flesh cells in vitro. PLoS One 13(5):e019699.  https://doi.org/10.1371/journal.pone.0196996CrossRefGoogle Scholar
  71. Irawan D (2009) Isolation of endophytic actinomycetes in medicinal plants and their potency as an antidiabetes based on α-glucosidase activity, IPB Scient Repos—Bogor Agricultural University 69. http://repository.ipb.ac.id/handle/123456789/12450
  72. Jagadevi S, Vidyasagar GM (2018) Phytochemical and antimicrobial evaluation of endophytic alternaria alternata isolated from Terminalia arjuna (Roxb.) Wight & Arn. Asian. J Pharm Pharmacol 4:456–461.  https://doi.org/10.31024/ajpp.2018.4.4.13.CrossRefGoogle Scholar
  73. Jalgaonwala RE, Mohite BV, Mahajan RT (2011) Natural products from plant associated endophytic fungi. J Microbiol Biotechnol Res 1:21–32. http://ajpp.in/uploaded/p163.pdfGoogle Scholar
  74. Jallow MFA, Dugassa-Gobena D, Vidal S (2008) Influence of an endophytic fungus on host plant selection by a polyphagous moth via volatile spectrum changes. Arthropod Plant Interact 2:53–62.  https://doi.org/10.1007/s11829-008-9033-8CrossRefGoogle Scholar
  75. Jasmine DJ, Agastian P (2013) In vitro antioxidant activity and in vivo alpha glucosidase activity of endophytic actinomycetes isolated from Catharanthus roseus (l.) G. Don. J Pharm Res 6:674–678.  https://doi.org/10.1016/j.jopr.2013.06.007.CrossRefGoogle Scholar
  76. Jia M, Chen L, Xin H-L, Zheng C-J, Rahman K, Han T, Qin L-P (2016) A friendly relationship between endophytic fungi and medicinal plants: a systematic review. Front Microbiol 7:906.  https://doi.org/10.3389/fmicb.2016.00906CrossRefPubMedPubMedCentralGoogle Scholar
  77. Jimenez-Romero C, Ortega-Barria E, Arnold AE, Cubilla-Rios L (2008) Activity against Plasmodium falciparum of lactones isolated from the endophytic fungus Xylaria sp. Pharm Biol 46:1–4.  https://doi.org/10.1080/13880200802215859CrossRefGoogle Scholar
  78. Joseph B, Priya RM (2011) Bioactive compounds from endophytes and their potential in pharmaceutical effect: a review. Am J Biochem Mol Biol 1:291–309.  https://doi.org/10.3923/ajbmb.2011.291.309CrossRefGoogle Scholar
  79. Kanchiswam CN, Malnoy M, Maffei M (2015) Bioprospecting bacterial and fungal volatiles for sustainable agriculture. Trends Plant Sci 20:206–211.  https://doi.org/10.1016/j.tplants.2015.01.004CrossRefGoogle Scholar
  80. Kandel SL, Joubert PM, Doty SL (2017) Bacterial endophyte colonization and distribution within plants. Microorganisms 5:77–102.  https://doi.org/10.3390/microorganisms5040077CrossRefPubMedCentralGoogle Scholar
  81. Kapoor N, Jamwal VL, Gandhi SG (2019) Endophytes as a source of high-value, bioactive metabolites. Phytochemistry:427–458.  https://doi.org/10.1007/978-3-319-90484-9_9
  82. Khan AL, Shahzad R, Al-Harrasi A, Lee IJ (2017) Endophytic microbes: a resource for producing extracellular enzymes. In: Maheshwari D, Annapurna K (eds) Endophytes: crop productivity and protection. Sustainable development and biodiversity, vol 16. Springer, Cham, pp 95–110.  https://doi.org/10.1007/978-3-319-66544-3_5CrossRefGoogle Scholar
  83. Khan N, Martínez-Hidalgo P, Ice TA, Maymon M, Humm EA, Nejat N, Sanders ER, Kaplan D, Hirsch AM (2018) Antifungal activity of Bacillus species against Fusarium and analysis of the potential mechanisms used in biocontrol. Front Microbiol 9:2363.  https://doi.org/10.3389/fmicb.2018.02363CrossRefPubMedPubMedCentralGoogle Scholar
  84. Kogel KH, Franken P, Huckelhoven R (2006) Endophyte or parasite what decides? Curr Opin Plant Biol 9:358–363.  https://doi.org/10.1016/j.pbi.2006.05.001CrossRefPubMedGoogle Scholar
  85. Kumar S, Agarwal RP, Shukla H, Rajak RC, Sandhu SS (2014) Endophytic fungi: as a source of antimicrobials bioactive compounds. World J Pharm Pharm Sci 3:1179–1197Google Scholar
  86. Lam KS (2007) New aspects of natural products in drug discovery. Trends Microbiol 15:279–289.  https://doi.org/10.1016/j.tim.2007.04.001CrossRefPubMedGoogle Scholar
  87. Lee J, Lobkovsky E, Pliam NB, Strobel GA, Clardy J (1995) Subglutinols A and B: immunosuppressive compounds from the endophytic fungus Fusarium subglutinans. J Organomet Chem 60:7076–7077.  https://doi.org/10.1021/acs.accountsCrossRefGoogle Scholar
  88. Lee JC, Strobel GA, Lobkovsky E, Clardy JC (1996) Torreyanic acid: a selectively cytotoxic quinine dimer from the endophytic fungus Pestalotiopsis microspora. J Organomet Chem 61:3232–3233CrossRefGoogle Scholar
  89. Li J, Strobel G, Harper J, Lobkovsky E, Clardy J (2000) Cryptocin, a potent tetramic acid antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Org Lett 2(6):767–770.  https://doi.org/10.1021/ol000008dCrossRefPubMedGoogle Scholar
  90. Li J, Lu C, Shen Y (2010) Macrolides of the bafilomycin family produced by Streptomyces sp. CS. J Antibiot 63:595–599.  https://doi.org/10.1038/ja.2010.95CrossRefPubMedGoogle Scholar
  91. Li H-Y, Shen M, Zhou Z-P, Li T, Wei Y-L, Lin L-B (2012) Diversity and cold adaptation of endophytic fungi from five dominant plant species collected from the Baima Snow Mountain, Southwest China. Fungal Divers 54:79–86.  https://doi.org/10.1007/s13225-012-0153-1CrossRefGoogle Scholar
  92. Li X, Li W, Chu L, White JF Jr, Xiong Z, Li H (2016) Diversity and heavy metal tolerance of endophytic fungi from Dysphania ambrosioides, a hyperaccumulator from Pb–Zn contaminated soils. J Plant Interact 11(1):186–192.  https://doi.org/10.1080/17429145.2016.1266043CrossRefGoogle Scholar
  93. Liaqat F, Eltem R (2016) Identification and characterization of endophytic bacteria isolated from in vitro cultures of peach and pear rootstocks. 3 Biotech 6:120.  https://doi.org/10.1007/s13205-016-0442-6CrossRefPubMedPubMedCentralGoogle Scholar
  94. Liotti RG, da Silva Figueiredo MI, da Silva GF, de Mendonça EAF, Soares MA (2018) Diversity of cultivable bacterial endophytes in Paullinia cupana and their potential for plant growth promotion and phytopathogen control. Microbiol Res 207:8–18.  https://doi.org/10.1016/j.micres.2017.10.011CrossRefPubMedGoogle Scholar
  95. Liu S, Dai H, Makhloufi G, Heering C, Janiak C, Hartmann R, Mándi A, Kurtán T, Müller WE, Kassack MU (2016) Cytotoxic 14-membered macrolides from a mangrove-derived endophytic fungus, Pestalotiopsis microspora. J Nat Prod 79(9):2332–2340.  https://doi.org/10.1021/acs.jnatprod.6b00473CrossRefPubMedGoogle Scholar
  96. Liu Y, Guo J, Li L, Mipeshwaree DA, Zhang Y, Osama AM, Nimaichand S, Li W (2017) Endophytic bacteria associated with endangered plant Ferula sinkiangensis K. M. Shen in an arid land: diversity and plant growth-promoting traits. J Arid Land 9(3):432–445.  https://doi.org/10.1007/s40333-017-0015-5CrossRefGoogle Scholar
  97. López JL, Alvarez F, Príncipe A, Salas ME, Lozano MJ, Draghi WO, Jofré E, Lagares A (2018) Isolation, taxonomic analysis, and phenotypic characterization of bacterial endophytes present in alfalfa (Medicago sativa) seeds. J Biotechnol 267:55–62.  https://doi.org/10.1016/j.jbiotec.2017.12.020CrossRefPubMedGoogle Scholar
  98. Losgen S, Magull J, Schulz B, Draeger S, Zeeck A (2008) Isofusidienols: novel chromone-3-oxepines produced by the endophytic fungus Chalara sp. Eur J Org Chem 4:698–703.  https://doi.org/10.1002/ejoc.200700839CrossRefGoogle Scholar
  99. Lumactud R, Fulthorpe RR (2018) Endophytic bacterial community structure and function of herbaceous plants from petroleum hydrocarbon contaminated and non-contaminated sites. Front Microbiol 9:1926.  https://doi.org/10.3389/fmicb.2018.01926CrossRefPubMedPubMedCentralGoogle Scholar
  100. Mallik MAB (2001) Selective isolation and screening of soil microorganisms for metabolites with herbicidal potential. Allelopathy Agrosystems 4:219–236.  https://doi.org/10.1300/J144v04n02_07CrossRefGoogle Scholar
  101. Manjunatha BS, Paul S, Aggarwal C, Bandeppa S, Govindasamy V, Dukare AS, Rathi MS, Satyavathi CT, Annapurna K (2019) Diversity and tissue preference of osmotolerant bacterial endophytes associated with pearl millet genotypes having differential drought susceptibilities. Microb Ecol 77(3):676–688.  https://doi.org/10.1007/s00248-018-1257-2CrossRefPubMedGoogle Scholar
  102. Massimo NC, Nandi Devan MM, Arendt KR, Wilch MH, Riddle JM, Furr SH, Steen C, U’Ren JM, Sandberg DC, Arnold AE (2015) Fungal endophytes in aboveground tissues of desert plants: infrequent in culture, but highly diverse and distinctive symbionts. Microb Ecol 70(1):61–76.  https://doi.org/10.1007/s00248-014-0563-6CrossRefPubMedPubMedCentralGoogle Scholar
  103. Miller RV, Miller CM, Kinney DG, Redgrave B, Sears J, Condron M et al (1998) Ecomycins, unique antimycotics from Pseudomonas viridiflava. J Appl Microbiol 84:937–944.  https://doi.org/10.1128/MMBR.67.4.491-502.2003CrossRefPubMedGoogle Scholar
  104. Mucciarelli M, Camusso W, Maffei M, Panicco P, Bicchi C (2007) Volatile terpenoids of endophyte-free and infected peppermint (Mentha piperita L.): chemical partitioning of a symbiosis. Microb Ecol 54:685–696.  https://doi.org/10.1007/s00248-007-9227-0CrossRefPubMedGoogle Scholar
  105. Mufti R, Amna Rafiqu M, Haq F, Hussain M, Munis Masood S, Mumtaz AS, Chaudhary HJ (2015) Genetic diversity and metal resistance assessment of endophytes isolated from Oxalis corniculata. Soil Environ 34(1):89–99. https://www.researchgate.net/publication/277233421Google Scholar
  106. Murugan KK, Poojari CC, Ryavalad C, Melappa G (2017) Antidiabetic activity of endophytic fungi, Penicillium species of Tabebuia argentea; in silico and experimental analysis. Res J Phytochem 11:90–110.  https://doi.org/10.3923/rjphyto.2017.90.110CrossRefGoogle Scholar
  107. Naik BS, Abrar S, Krishnappa M (2019) Industrially important enzymes from fungal endophytes. In: Yadav A, Mishra S, Singh S, Gupta A (eds) Recent advancement in white biotechnology through Fungi. Fungal biology. Springer, Cham, pp 263–280.  https://doi.org/10.1007/978-3-030-10480-1_7CrossRefGoogle Scholar
  108. Nair DN, Padmavathy S (2014) Impact of endophytic microorganisms on plants, environment and humans. Sci World J 2014:250693.  https://doi.org/10.1155/2014/250693CrossRefGoogle Scholar
  109. Oses R, Frank AC, Valenzuela S, Rodríguez J (2018) Nitrogen fixing endophytes in forest trees. In: Pirttilä A, Frank A (eds) Endophytes of forest trees. Forestry sciences, vol 86. Springer, Cham, pp 191–204.  https://doi.org/10.1007/978-3-319-89833-9_9CrossRefGoogle Scholar
  110. Pereira SIA, Monteiro C, Vega AL, Castro PML (2016) Endophytic culturable bacteria colonizing Lavandula dentata L. plants: Isolation, characterization and evaluation of their plant growth-promoting activities. Ecol Eng 87:91–97.  https://doi.org/10.1016/j.ecoleng.2015.11.033CrossRefGoogle Scholar
  111. Petrini O (1991) Fungal endophytes of tree leaves. In: Andrews JH, Hirano SS (eds) Microbial ecology of leaves. Springer-Verlag, New York, NY, pp 179–197.  https://doi.org/10.1007/978-1-4612-3168-4_9CrossRefGoogle Scholar
  112. Pimentel MR, Molina G, Dionisio AP, Maróstica MR, Pastore GM (2011) Use of endophytes to obtain bioactive compounds and their application in biotransformation process. Biotechnol Res Int.  https://doi.org/10.4061/2011/576286
  113. Postma JWM, Olsson PA, Falkengren-Grerup U (2007) Root colonisation by arbuscular mycorrhizal, fine endophytic and dark septate fungi across a pH gradient in acid beech forests. Soil Biol Biochem 39(2):400–408.  https://doi.org/10.1016/j.soilbio.2006.08.007CrossRefGoogle Scholar
  114. Potshangbam M, Devi SI, Sahoo D, Strobel GA (2017) Functional characterization of endophytic fungal community associated with Oryza sativa L. and Zea mays L. Front Microbiol 8:325–330.  https://doi.org/10.3389/fmicb.2017.00325CrossRefPubMedPubMedCentralGoogle Scholar
  115. Powell RG, Smith CR (1980) Antitumor agents from higher plants. In: The resource potential in phytochemistry, vol 14. Springer, New York, pp 23–51.  https://doi.org/10.1007/978-1-4684-8309-3_2CrossRefGoogle Scholar
  116. Praptiwi MR, Wulansari D, Fathoni A, Agusta A (2018) Antibacterial and antioxidant activities of endophytic fungi extracts of medicinal plants from Central Sulawesi. J Appl Pharmaceut Sci 8(08):069–074.  https://doi.org/10.7324/JAPS.2018.8811CrossRefGoogle Scholar
  117. Pujiyanto S, Lestari Y, Suwanto A, Budiarti S, Darusman LK (2012) Alpha-glucosidase inhibitor activity and characterization of endophytic actinomycetes isolated from some Indonesian diabetic medicinal plants. Int J Pharm Pharm Sci 4(1):327–333. https://www.researchgate.net/publication/262728745Google Scholar
  118. Qin S, Xing K, Jiang J-H, Xu L-H, Li W-J (2011) Biodiversity, bioactive natural products and biotechnological potential of plant-associated endophytic actinobacteria. Appl Microbiol Biotechnol 89(3):457–473.  https://doi.org/10.1007/s00253-010-2923-6CrossRefPubMedGoogle Scholar
  119. Rajamanikyam M, Vadlapudi V, Amanchy R, Upadhyayula SM (2017) Endophytic fungi as novel resources of natural therapeutics. Braz Arch Biol Technol 60:e17160542. http://www.plantsjournal.com/archives/?year=2018&vol=6&issue=1&part=C&ArticleId=764CrossRefGoogle Scholar
  120. Ramalakshmi K, Prasanna VK, Magesh K, Sanjana R, Siril JS, Ravibalan KA (2018) potential surface sterilization technique and culture media for the isolation of endophytic bacteria from Acalypha indica and its antibacterial activity. J Med Plant Stud 6:181–184. http://www.plantsjournal.com/archives/?year=2018&vol=6&issue=1&part=C&ArticleId=764Google Scholar
  121. Rani V (2016) Endophytes isolated from the plants of Himachal Pradesh and their importance. Int J Curr Microbiol App Sci 5:105–110.  https://doi.org/10.20546/ijcmas.2016.509.012CrossRefGoogle Scholar
  122. Richardson AE, Hadobas PA (1997) Soil isolates of Pseudomonas spp. that utilize inositol phosphates. Can J Microbiol 43:509–516.  https://doi.org/10.1139/m97-073CrossRefPubMedGoogle Scholar
  123. Rohini S, Aswani R, Kannan M, Sylas VP, Radhakrishnan EK (2018) Culturable endophytic bacteria of ginger rhizome and their remarkable multi-trait plant growth-promoting features. Curr Microbiol 75:505–511.  https://doi.org/10.1007/s00284-017-1410-zCrossRefPubMedGoogle Scholar
  124. Saad MMG (2019) Herbicidal activities of endophytic fungi and its secondary metabolites. Allelopath J 46:51–60.  https://doi.org/10.26651/allelo.j/2019-46-2-1208CrossRefGoogle Scholar
  125. Saha M, Sarkar S, Sarkar B, Sharma BK, Bhattacharjee S, Tribedi P (2016) Microbial siderophores and their potential applications: a review. Environ Sci Pollut Res 23:3984–3999.  https://doi.org/10.1007/s11356-015-4294-0CrossRefGoogle Scholar
  126. Sánchez-Cruz R, Vázquez IT, Batista-García RA, Méndez-Santiago EW, del Rayo Sánchez-Carbente M, Leija A, Lira-Ruan V, Hernández G, Wong-Villarreal A, Folch-Mallol JL (2019) Isolation and characterization of endophytes from nodules of Mimosa pudica with biotechnological potential. Microbiol Res 218:76–86.  https://doi.org/10.1016/j.micres.2018.09.008CrossRefPubMedGoogle Scholar
  127. Santos CM, Ribeiro AS, Garcia A, Polli AD, Polonio JC, Azevedo JL, Pamphile JA (2019) Enzymatic and antagonist activity of endophytic fungi from Sapindus saponaria L. (Sapindaceae). Acta Biol Colomb 24(2):322–330.  https://doi.org/10.15446/abc.v24n2.74717CrossRefGoogle Scholar
  128. Satari AH, Zargar MI, Shah WA, Bansal R, Bhat MF (2018) Isolation, molecular identification, phytochemical screening and in vitro antioxidant activity of endophytic fungi from Achillea millefolium Linn. J Pharmacogn Phytochem 7:87–92. http://www.phytojournal.com/archives/?year=2018&vol=7&issue=4&ArticleId=4878Google Scholar
  129. Sato F, Kumagai H (2013) Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research. Proc Jpn Acad Ser B 89:165–181.  https://doi.org/10.2183/pjab.89.165CrossRefGoogle Scholar
  130. Savi DC, Shaaban KA, Vargas N, Ponomareva LV, Possiede YM, Thorson JS, Glienke C, Rohr J (2015) Microbispora sp. LGMB259 endophytic actinomycete isolated from Vochysia divergens (Pantanal, Brazil) producing β-carbolines and indoles with biological activity. Curr Microbiol 70:345–354.  https://doi.org/10.1007/s00284-014-0724-3CrossRefPubMedGoogle Scholar
  131. Schwyn B, Neilands JB (1987) Universal chemical assay for the detection and determination of siderophores. Anal Biochem 160:45–56.  https://doi.org/10.1016/0003-2697(87)90612-9CrossRefGoogle Scholar
  132. Selvi BK, Balagengatharathilagam P (2014) Isolation and screening of endophytic fungi from medicinal plants of Virudhunagar district for antimicrobial activity. Int J Sci Nat 5:147–155. https://pdfs.semanticscholar.org/9ff9/9206cbf3bc73d3f129e102a5968a26ec7ed7.pdfGoogle Scholar
  133. Shabanamol S, Divya K, George TK, Rishad KS, Sreekumar TS, Jisha MS (2018) Characterization and in planta nitrogen fixation of plant growth promoting endophytic diazotrophic Lysinibacillus sphaericus isolated from rice (Oryza sativa). Physiol Mol Plant Pathol 102:45–54.  https://doi.org/10.1016/j.pmpp.2017.11.003CrossRefGoogle Scholar
  134. Sharma P, Baunthiyal M (2018) Endophytic Actinobacteria from Pinus roxburghii: isolation, diversity and antimicrobial potential against human pathogens. J Pharmacogn Phytochem 7:3021–3027. http://www.phytojournal.com/archives/2018/vol7issue5/PartAY/7-5-175-234.pdfGoogle Scholar
  135. Shen M, Liu L, Li DW, Zhou WN, Zhou ZP, Zhang CF, Luo YY, Wang HB, Li HY (2013) The effect of endophytic Peyronellaea from heavy metal-contaminated and uncontaminated sites on maize growth, heavy metal absorption and accumulation. Fungal Ecol 6:539–545.  https://doi.org/10.1016/j.funeco.2013.08.001CrossRefGoogle Scholar
  136. Shiono Y, Murayama T, Takahashi K, Okada K, Katohda S, Ikeda M (2005) Three oxygenated Cyclohexenone derivatives produced by an endophytic fungus. Biosci Biotechnol Biochem 69:287–292.  https://doi.org/10.1271/bbb.69.287CrossRefPubMedGoogle Scholar
  137. Sindhu R, Binod P, Pandey A (2017) 1—α-Amylases. In: Pandey A, Negi S, Soccol CR (eds) Current developments in biotechnology and bioengineering. Elsevier, Amsterdam, pp 3–24.  https://doi.org/10.1016/B978-0-444-63662-1.00001-4CrossRefGoogle Scholar
  138. Singh R, Dubey AK (2015) Endophytic actinomycetes as emerging source for therapeutic compounds. Indo Global J Pharm Sci 5:106–116. https://www.researchgate.net/publication/298423646Google Scholar
  139. Singh M, Kumar A, Singh R, Pandey KD (2017) Endophytic bacteria: a new source of bioactive compounds. 3 Biotech 7:315.  https://doi.org/10.1007/s13205-017-0942-zCrossRefPubMedPubMedCentralGoogle Scholar
  140. Singh H, Naik B, Kumar V, Bisht GS (2018) Screening of endophytic actinomycetes for their herbicidal activity. Annal Agrarian Sci 16:101–107.  https://doi.org/10.1016/j.aasci.2017.11.001CrossRefGoogle Scholar
  141. Singh J, Kundu D, Das M, Banerjee R (2019) Enzymatic processing of juice from fruits/vegetables: an emerging trend and cutting edge research in food biotechnology. In: Kuddus M (ed) Enzymes in food biotechnology. Academic Press, New York, pp 419–432.  https://doi.org/10.1016/B978-0-12-813280-7.00024-4CrossRefGoogle Scholar
  142. Smith MM, Warren VA, Thomas BS, Brochu RM, Ertel EA, Rohrer S, Schaeffer J, Schmatz D, Petuch BR, Tang YS (2000) Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator. Biochemistry 39:5543–5554.  https://doi.org/10.1021/bi992943iCrossRefPubMedGoogle Scholar
  143. Snipes CE, Duebelbeis DO, Olson M, Hahn DR, Dent Iii WH, Gilbert JR, Werk TL, Davis GE, Lee-Lu R, Graupner PR (2007) The ansacarbamitocins: polar ansamitocin derivatives. J Nat Prod 70(10):1578–1581CrossRefGoogle Scholar
  144. Stein T (2005) Bacillus subtilis antibiotics: structures, syntheses and specific functions. Mol Microbiol 56:845–857.  https://doi.org/10.1111/j.1365-2958.2005.04587.xCrossRefPubMedGoogle Scholar
  145. Stierle A, Strobel G, Stierle D (1993) Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260:214–216.  https://doi.org/10.1126/science.8097061CrossRefPubMedGoogle Scholar
  146. Stierle AA, Stierle DB, Bugni T (1999) Sequoiatones A and B: novel antitumour metabolites isolated from a redwood endophyte. J Organomet Chem 64:5479–5484.  https://doi.org/10.1021/jo990277lCrossRefGoogle Scholar
  147. Strobel GA (2003) Endophytes as sources of bioactive products. Microbes Infect 5:535–544. https://www.ncbi.nlm.nih.gov/pubmed/12758283CrossRefGoogle Scholar
  148. Strobel GA, Daisy B (2003) Bioprospecting for microbial endophytes and their natural products. Microbiol Mol Biol Rev 67:491–502.  https://doi.org/10.1128/mmbr.67.4.491-502.2003CrossRefPubMedPubMedCentralGoogle Scholar
  149. Strobel G, Ford E, Worapong J, Harper JK, Arif AM, Grant DM, Fung PC, Chau RMW (2002) Isopestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities. Phytochemistry 60(2):179–183.  https://doi.org/10.1016/s0031-9422(02)00062-6CrossRefPubMedGoogle Scholar
  150. Subbulakshmi GK, Thalavaipandian A, Bagyalakshmi RV, Rajendran A (2012) Bioactive endophytic fungal isolates of Biota orientalis (L) Endl., Pinus excelsa Wall. and Thujaoccidentalis L. Int J Adv Life Sci 4:9–15. http://www.unitedlifejournals.com/ijals/view-pdf.php?id=34Google Scholar
  151. Sun RW, Chen R, Chung NP, Ho CM, Lin CL, Che CM (2005) Silver nanoparticles fabricated in Hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells. Chem Commun (Camb) 40:5059–5061.  https://doi.org/10.1039/b510984aCrossRefGoogle Scholar
  152. Sun H, He Y, Xiao Q, Ye R, Tian Y (2013) Isolation, characterization, and antimicrobial activity of endophytic bacteria from Polygonum cuspidatum. Afr J Microbiol Res 7:1496–1504.  https://doi.org/10.5897/AJMR12.899.CrossRefGoogle Scholar
  153. Sunitha VH, Devi DN, Srinivas C (2013) Extracellular enzymatic activity of endophytic fungal strains isolated from medicinal plants. World J Agricult Sci 9(1):01–09.  https://doi.org/10.5829/idosi.wjas.2013.9.1.72148.CrossRefGoogle Scholar
  154. Sunkar S, Nachiyar CV (2012) Biogenesis of antibacterial silver nanoparticles using the endophytic bacterium Bacillus cereus isolated from Garcinia xanthochymus. Asian Pac J Trop Biomed 2:953–959.  https://doi.org/10.1016/S2221-1691(13)60006-4CrossRefPubMedPubMedCentralGoogle Scholar
  155. Syed CS, Mounika PP, Mounika Y, Mounika S, Kumar S, Bai VT, Audipudi AV (2017) Evaluation of antimicrobial and antibiotic sensitivity of Chilli root endophytic bacteria for eco-friendly biofertilizer. Int J Curr Microbiol App Sci 5:45–53. https://www.ijcmas.com/special/5/Chandini%20S.%20Syed2,%20et%20al.pdfGoogle Scholar
  156. Szymańska S, Borruso L, Brusetti L, Hulisz P, Furtado B, Hrynkiewicz K (2018) Bacterial microbiome of root-associated endophytes of Salicornia europaea in correspondence to different levels of salinity. Environ Sci Pollut Res Int 25:25420–25431.  https://doi.org/10.1007/s11356-018-2530-0CrossRefPubMedPubMedCentralGoogle Scholar
  157. Taechowisan T, Chanaphat S, Ruensamran W, Phutdhawong WS (2012) Anti-inflammatory effect of 3-methylcarbazoles on RAW 2647 cells stimulated with LPS, polyinosinic-polycytidylic acid and Pam3CSK. Adv Microbiol 2:98–103.  https://doi.org/10.3390/molecules16087132.CrossRefGoogle Scholar
  158. Taechowisan T, Chaisaeng S, Phutdhawong WS (2017) Antibacterial, antioxidant and anticancer activities of biphenyls from Streptomyces sp. BO-07: an endophyte in Boesenbergia rotunda (L.) Mansf A. Food Agric Immunol 28:1330–1346.  https://doi.org/10.1080/09540105.2017.1339669CrossRefGoogle Scholar
  159. Taylor PL, Omotoso O, Wiskel JB, Mitlin D, Burrell RE (2005) Impact of heat on nanocrystalline silver dressings. Part II: physical properties. Biomaterials 26:7230–7240.  https://doi.org/10.1016/j.biomaterials.2005.05.041.CrossRefPubMedGoogle Scholar
  160. Turbyville TJ, Wijeratne EMK, Liu MX, Burns AM, Seliga CJ, Luevano LA, David CL, Faeth SH, Whitesell L, Gunatilaka AAL (2006) Search for HSP 90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. J Nat Prod 69:178–184.  https://doi.org/10.1021/np058095b.CrossRefPubMedPubMedCentralGoogle Scholar
  161. Ullah A, Mushtaq H, Ali U, Hakim AE, Mubeen S (2018) Screening, isolation, biochemical and plant growth promoting characterization of endophytic bacteria. Microbiol Curr Res 2(3):62–68.  https://doi.org/10.4066/2591-8036.18-368.CrossRefGoogle Scholar
  162. Uzma F, Konappa NM, Chowdappa S (2016) Diversity and extracellular enzyme activities of fungal endophytes isolated from medicinal plants of Western Ghats, Karnataka. Egypt J Basic Appl Sci 3(4):335–342.  https://doi.org/10.1016/j.ejbas.2016.08.007CrossRefGoogle Scholar
  163. van Lenteren JC, Bolckmans K, Köhl J, Ravensberg WJ, Urbaneja A (2018) Biological control using invertebrates and microorganisms: plenty of new opportunities. Biol Control 63:39–59.  https://doi.org/10.1007/s10526-017-9801-4CrossRefGoogle Scholar
  164. Verma SK, Gond SK, Mishra A, Sharma VK, Kumar J, Singh DK, Kumar A, Goutam J, Kharwar RN (2014) Impact of environmental variables on the isolation, diversity and antibacterial activity of endophytic fungal communities from Madhuca indica Gmel. at different locations in India. Ann Microbiol 64(2):721–734.  https://doi.org/10.1007/s13213-013-0707-9CrossRefGoogle Scholar
  165. Verma SK, Kingsley KL, Bergen MS, Kowalski KP, White JF (2018) Fungal disease prevention in seedlings of rice (Oryza sativa) and other grasses by growth-promoting seed-associated endophytic bacteria from invasive Phragmites australis. Microorganisms 6(1):E21.  https://doi.org/10.3390/microorganisms6010021CrossRefPubMedGoogle Scholar
  166. Villarreal-Delgado MF, Villa-Rodríguez ED, Cira-Chávez LA, Estrada Alvarado MI, Parra-Cota FI, de los Santos-Villalobos S (2018) The genus bacillus as a biological control agent and its implications in the agricultural biosecurity. Mex J Phytopathol 36:95–130.  https://doi.org/10.18781/R.MEX.FIT.1706-5CrossRefGoogle Scholar
  167. Vu HT, Nguyen DT, Nguyen HQ, Chu HH, Chu SK, Chau MV, Phi QT (2018) Antimicrobial and cytotoxic properties of bioactive metabolites produced by Streptomyces cavourensis YBQ59 isolated from Cinnamomum cassia prels in yen bai province of vietnam. Curr Microbiol 75:1247–1255.  https://doi.org/10.1007/s00284-018-1517-xCrossRefPubMedGoogle Scholar
  168. Vyas P, Kaur R (2019) Culturable stress-tolerant plant growth-promoting bacterial endophytes associated with Adhatoda vasica. J Soil Sci Plant Nutr 19:290–298.  https://doi.org/10.1007/s42729-019-00028-9CrossRefGoogle Scholar
  169. Wagenaar M, Corwin J, Strobel GA, Clardy J (2000) Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella. J Nat Prod 63:1692–1695.  https://doi.org/10.1021/np0002942CrossRefPubMedGoogle Scholar
  170. Waheeda K, Shyam KV (2017) Formulation of novel surface sterilization method and culture media for the isolation of endophytic actinomycetes from medicinal plants and its antibacterial activity. J Plant Pathol Microbiol 8:399.  https://doi.org/10.4172/2157-7471.1000399CrossRefGoogle Scholar
  171. Webber J (1981) A natural biological control of Dutch elm disease. Nature 292(5822):449–451. http://agris.fao.org/agris-search/search.do?recordID=GB19820813296CrossRefGoogle Scholar
  172. Yu H, Zhang L, Li L, Sun P, Qin L (2010) Recent developments and future prospects of antimicrobial metabolites produced by endophytes. Microbiol Res 165:437–449.  https://doi.org/10.1016/j.micres.2009.11.009CrossRefPubMedGoogle Scholar
  173. Zhang B, Salituro G, Szalkowski D, Li Z, Zhang Y, Royo I, Vilella D, Dez M, Pelaez F, Ruby C, Kendall RL, Mao X, Griffin P, Calaycay J, Zierath JR, Heck JV, Smith RG, Moller DE (1999) Discovery of small molecule insulin mimetic with antidiabetic activity in mice. Science 284:974–981.  https://doi.org/10.1126/science.284.5416.974.CrossRefPubMedGoogle Scholar
  174. Zhang Q, Zhang J, Yang L, Zhang L, Jiang D, Chen W, Li G (2014) Diversity and biocontrol potential of endophytic fungi in Brassica napus. Biol Control 72:98–108.  https://doi.org/10.1016/j.biocontrol.2014.02.018CrossRefGoogle Scholar
  175. Zhang H, Bai X, Zhang M, hen J, Wang H (2018) Bioactive natural products from endophytic microbes. Nat Product J 8:86–108.  https://doi.org/10.2174/2210315508666180103160508CrossRefGoogle Scholar
  176. Zhao K, Penttinen P, Guan T, Xiao J, Chen Q, Xu J (2011) The diversity and anti-microbial activity of endophytic actinomycetes isolated from medicinal plants in Panxi Plateau China. Curr Microbiol 62:182–190.  https://doi.org/10.1007/s00284-010-9685-3CrossRefPubMedGoogle Scholar
  177. Zheng YK, Miao CP, Chen HH, Huang FF, Xia YM, Chen YW, Zhao LX (2017) Endophytic fungi harbored in Panax notoginseng: diversity and potential as biological control agents against host plant pathogens of root-rot disease. J Ginseng Res 41:353–360.  https://doi.org/10.1016/j.jgr.2016.07.005CrossRefPubMedGoogle Scholar
  178. Zou WX, Meng JC, Lu H, Chen GX, Shi GX, Zhang TY, Tan RX (2000) Metabolites of Colletotrichum gloeosporioides, an endophytic fungus in Artemisia mongolica. J Nat Prod 63:1529–1530.  https://doi.org/10.1021/np000204tCrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Sneh Sharma
    • 1
  • Varsha Rani
    • 2
  • Raj Saini
    • 3
  • Madan L. Verma
    • 4
    Email author
  1. 1.Department of BiotechnologyDr. Y.S. Parmar University of Horticulture and ForestryNeri, HamirpurIndia
  2. 2.Department of BiotechnologyShoolini UniversitySolanIndia
  3. 3.Department of Basic SciencesDr. Y.S. Parmar University of Horticulture and ForestryNeri, HamirpurIndia
  4. 4.Department of BiotechnologySchool of Basic Sciences, Indian Institute of Information TechnologyUnaIndia

Personalised recommendations