Quorum Quenching for Sustainable Environment: Biology, Mechanisms, and Applications

  • Naga Raju MaddelaEmail author
  • Luz Cecilia García Cruzatty
  • Daniel Alfredo Leal-Alvarado
  • Jessenia Castro Olaya
  • Sagnik Chakraborty
  • Anupam Mukherjee
Part of the Microorganisms for Sustainability book series (MICRO, volume 22)


Quorum sensing signaling is a hierarchal system in bacteria to communicate with each other and coordinate their activities. Prevention of the QS pathway by disrupting signals is called quorum quenching (QQ), which is essential not just in medicine and healthcare settings but also in membrane bioreactors, aquaculture, and agriculture. QQ could be achieved either by interfering with the QS signaling pathway (e.g., signal generator or receptor) or intercepting the QS molecules. Research on QQ led to the development of strategies that mitigate biofilm-based problems in medicine, agronomy, and water engineering. The QQ-strategy is being given importance in recent times as there is an immediate need to search for an alternative or a complementary approach to phytochemicals and antibiotics. This chapter starts with the historical aspects of QQ; furthermore, it highlights the global research in the area of QQ and the mechanism of quenching pathways. Afterward, applications of QQ-strategies in medicine, agriculture, aquaculture, and water engineering are discussed. Finally, challenges and prospects of QQ technology are delineated.


Quorum quenching Mechanism Medicine Agriculture Aquaculture Wastewater treatment 



N-acyl homoserine lactones


Auto Inducer 2


Autoinducing peptides


Anti-microbial resistance




Forward osmosis-MBR




Guanosine monophosphate


International Development Research Centre


Moving bed biofilm reactors


Membrane biofilm reactors


Membrane bioreactors


Minimum inhibitory concentration


Methicillin-resistant Staphylococcus aureus


National Institute of Health


N-terminal nucleophile


Open reading frames


Phosphotriesterase-like lactonases




Quorum quenching


QQ-anaerobic MBR


QQ-reverse osmosis


Quorum sensing


Quorum sensing inhibitors


Silver nanoparticles


United States of America


World Health Organization


Wastewater treatment



Dr. Naga Raju Maddela greatly acknowledges the Universidad Téchnica de Manabí, Portoviejo, Manabí, Ecuador, for the facilities and encouragement and his colleagues in the Instituto de Investigación and Facultad la Ciencias la Salud for their help in literature collection. The authors also thank Editor Dr. Pankaj Kumar Arora (Assistant Professor, Babasaheb Bhimrao Ambedkar University, Lucknow, India) for guidance and accepting our request to write this chapter.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Naga Raju Maddela
    • 1
    • 2
    Email author
  • Luz Cecilia García Cruzatty
    • 1
    • 3
  • Daniel Alfredo Leal-Alvarado
    • 1
    • 3
  • Jessenia Castro Olaya
    • 3
  • Sagnik Chakraborty
    • 4
  • Anupam Mukherjee
    • 5
  1. 1.Instituto de InvestigaciónUniversidad Técnica de ManabíPortoviejoEcuador
  2. 2.Faculdad la Ciencias la SaludUniversidad Técnica de ManabíPortoviejoEcuador
  3. 3.Faculdad de AgronomíaUniversidad Técnica de ManabíPortoviejoEcuador
  4. 4.School of Energy & Environmental EngineeringHebei University of TechnologyTianjinPeople’s Republic of China
  5. 5.Department of Chemical EngineeringHaldia Institute of TechnologyHaldia, Purba MedinipurIndia

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