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Glutarylation at Histone H4 Lysine 91 Modulates Chromatin Assembly

  • Xiucong BaoEmail author
Chapter
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Part of the Springer Theses book series (Springer Theses)

Abstract

The genomic information of eukaryotic cells is stored in chromatin, a compacted structure formed by packaging DNA around proteins called histones (Tan and Davey in Curr Opin Struct Biol 21:128–136, 2003, Richmond and Davey in Nature 423:145–150, 2011 [1, 2]). The organization of chromatin is not static but highly dynamic (Widom in Ann Rev Biophys Biomol Struct 27:285–327, 1998, Luger in Chrom Res Int J Mol Supramol Evol Asp Chrom Biol 14:5–16, 2006 [3, 4]). By affecting DNA accessibility, the dynamic structure of chromatin plays essential roles in many fundamental nuclear processes, including gene transcription, DNA replication and DNA damage repair (Ehrenhofer-Murray in Eur J Biochem FEBS 271:2335–2349, 2004, Groth et al. in Cell 128:721–733, 2007 [5, 6]).

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© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  1. 1.Department of ChemistryThe University of Hong KongHong KongChina

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