Immunotherapy for Colon Cancer: Recent Perspectives

  • Christoffer B. Lambring
  • Chloe Smith
  • Sohail Siraj
  • Krishna Patel
  • Riyaz BashaEmail author
Part of the Diagnostics and Therapeutic Advances in GI Malignancies book series (DTAGIM)


Colorectal cancer (CRC) is third in cancer-related deaths among male and female populations. It is a slowly progressing malignancy and therefore, early detection of ulcers or the non-malignant polyps can prevent the disease and result in better patient outcomes. There are several treatment regimens, including chemotherapy and radiation that have been used for decades in treating CRC. Morbidity caused by intensive therapy and limitations in treatment due to late stage diagnoses impact the survival of CRC patients and dampen the quality of life of surviving patients. Alternative approaches such as immunotherapy have been tested for some time to address the issues associated with intensive chemotherapy. Several strategies that have been studied in pre-clinical models for CRC are recently gaining attention due to promising results, leading to clinical trials. Strategies including the use of monoclonal antibodies, vaccines, T cell stimulators, and immune checkpoint inhibitors are currently in clinical trials. The results of these clinical trials are crucial for immunotherapy usage as a part of standard care. Less toxic and more specific immunotherapeutic approaches are urgently required to address the morbidity of CRC patients, these approaches have the ability to reduce metastasis and increase the survival rate in CRC patients.


Colorectal cancer Immunotherapy PD-1 inhibitors Cancer vaccines 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Christoffer B. Lambring
    • 1
  • Chloe Smith
    • 2
  • Sohail Siraj
    • 1
  • Krishna Patel
    • 1
  • Riyaz Basha
    • 1
    Email author
  1. 1.Texas College of Osteopathic Medicine, UNT Health Science CenterFort WorthUSA
  2. 2.Old Dominion UniversityNorfolkUSA

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