Microbiological Advances in Bioactives from High Altitude

  • Suresh Chandra Phulara
  • Nazia Ahmad
  • Bidyut Mazumdar
  • Vikrant Singh Rajput
Part of the Rhizosphere Biology book series (RHBIO)


Owing to high altitude and extreme environmental conditions, Himalayas represents one of the biodiversity hotspot in India and home to several plants and microbial species. Thus, the plants and microbes present in these regions exhibit characteristic adaptations. The plants of high altitude Himalayan region are rich in varied secondary metabolites possessing several pharmacological activities. In this chapter, we focused on the antimicrobial and anticancer activities of the secondary metabolites present in the high-altitude plants and microbes, respectively, from the Himalayas. The ethnopharmacology of several plant species have been discussed which have been reported for antimicrobial activity by their essential oils. The major constituents of the essential oils that are responsible for such properties have also been explored. Later, the specific classes of secondary metabolites have been examined for their anticancer potential. However, the recognition of tremendous medicinal applications of Himalayan plants has resulted into their heavy exploitation in the past few decades. Due to this, several plant species like the Himalayan Yew have become endangered. To reduce their over exploitation and to obtain high-altitude bioactives in a sustainable manner, microbial production of such compounds have been investigated in past two decades. In the last section, we discuss about the biosynthesis of one of the largest class of bioactives i.e. terpenoids from microbial sources. Overall, the present chapter boasts the antimicrobial and anticancer potential of the bioactives from high-altitude and their sustainable production approach through microbial system.


Antimicrobials Higher altitude bioactives Ethnopharmacology Himalaya Biodiversity 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Suresh Chandra Phulara
    • 1
  • Nazia Ahmad
    • 2
  • Bidyut Mazumdar
    • 3
  • Vikrant Singh Rajput
    • 2
  1. 1.Department of BiotechnologyKoneru Lakshmaiah Education FoundationGunturIndia
  2. 2.School of BiotechnologyJawaharlal Nehru UniversityNew DelhiIndia
  3. 3.Department of Chemical EngineeringNational Institute of Technology RaipurRaipurIndia

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