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Traditional Plant Compounds for the Treatment of Neuropsychiatric Disorders

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Abstract

Neuropsychiatric disorders affect a massive chunk of world population directly or indirectly. The disability caused by neuropsychiatric disorders has a huge burden on one’s personal and family life and on the society, in general. Unfortunately, the affected person faces negative impact of discrimination everywhere, and the families too have to make adjustments and compromises in today’s life events, affecting their quality of life. The neuropsychiatric disorders are complex, which reflects in their inept treatment regimen. The direct connection of neuropsychiatric disorders with one’s behaviour makes them different from the rest of human health complications. The drugs and treatments are usually symptom specific, and the symptoms are usually overlapping between these disorders making the treatment non-specific. The side effects of the medicine and therapies for neuropsychiatric disorders are enormous and often lead to further complications due to off-targets. Plant-based treatments have been a good option of treating these disorders as they come with more advantages than side effects to the human body. So, plant-based therapies stand as a considerable option for treating these disorders.

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References

  • Agid Y, Buzsáki G, Diamond DM, Frackowiak R, Giedd J, Girault JA, Grace A, Lambert JJ, Manji H, Mayberg H, Popoli M, Prochiantz A, Richter-Levin G, Somogyi P, Spedding M, Svenningsson P, Weinberger D (2007) How can drug discovery for psychiatric disorders be improved? Nat Rev Drug Discov 6(3):189–201

    Article  PubMed  CAS  Google Scholar 

  • Amin DN, Masocha W, Ngan’dwe K, Rottenberg M, Kristensson K (2008) Suramin and minocycline treatment of experimental African trypanosomiasis at an early stage of parasite brain invasion. Acta Trop 106(1):72–74

    Article  PubMed  CAS  Google Scholar 

  • Anwar M, Nanda N, Bhatia A, Akhtar R, Mahmood S (2013) Effect of antioxidant supplementation on digestive enzymes in radiation induced intestinal damage in rats. Int J Radiat Biol 89(12):1061–1070

    Article  PubMed  CAS  Google Scholar 

  • Anwar M, Ahmad S, Akhtar R, Mahmood A, Mahmood S (2017) Antioxidant supplementation: a linchpin in radiation-induced enteritis. Technol Cancer Res Treat 16(6):676–691. https://doi.org/10.1177/1533034617707598

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Arvindakshan M, Sitasawad S, Debsikdar V, Ghate M, Evans D, Horrobin DF, Bennett C, Ranjekar PK, Mahadik SP (2003) Essential polyunsaturated fatty acid and lipid peroxide levels in never-medicated and medicated schizophrenia patients. Biol Psychiatry 53(1):56–64

    Article  PubMed  CAS  Google Scholar 

  • Bahari-Javan S, Maddalena A, Kerimoglu C, Wittnam J, Held T, Bähr M (2012) HDAC1 regulates fear extinction in mice. J Neurosci 32(15):5062–5073

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Beauharnois JM, Bolívar BE, Welch JT (2013) Sirtuin 6: a review of biological effects and potential therapeutic properties. Mol Biosyst 9(7):1789–1806

    Article  PubMed  CAS  Google Scholar 

  • Benes FM, Lim B, Matzilevich D, Walsh JP, Subburaju S, Minns M (2007) Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc Natl Acad Sci U S A 104(24):10164–10169

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bergamaschi MM, Queiroz RH, Zuardi AW, Crippa JA (2011) Safety and side effects of cannabidiol, a Cannabis sativa constituent. Curr Drug Saf 6(4):237–249

    Article  PubMed  CAS  Google Scholar 

  • Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Judd F, Katz F, Katz P, Ording-Jespersen S, Little J, Conus P, Cuenod M, Do KQ, Bush AI (2008) N-acetyl cysteine as a glutathione precursor for schizophrenia--a double-blind, randomized, placebo-controlled trial. Biol Psychiatry 64(5):361–368

    Article  PubMed  CAS  Google Scholar 

  • Berk M, Dean O, Cotton SM, Gama CS, Kapczinski F, Fernandes BS, Kohlmann K, Jeavons S, Hewitt K, Allwang C, Cobb H, Bush AI, Schapkaitz I, Dodd S, Malhi GS (2011) The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial. J Affect Disord 135(1–3):389–394

    Article  PubMed  CAS  Google Scholar 

  • Blessing EM, Steenkamp MM, Manzanares J, Marmar CR (2015) Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics 12(4):825–836

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Borgelt LM, Franson KL, Nussbaum AM, Wang GS (2013) The pharmacologic and clinical effects of medical cannabis. Pharmacotherapy 33(2):195–209

    Article  PubMed  CAS  Google Scholar 

  • Bose LV, Varghese GK, Habtemariam S (2013) Identification of acteoside as the active antioxidant principle of Premna serratifolia root wood tissues. Phytopharmacology 4(2):228–236

    CAS  Google Scholar 

  • Bošković M, Vovk T, Kores Plesničar B, Grabnar I (2011) Oxidative stress in schizophrenia. Curr Neuropharmacol 9(2):301–312

    Article  PubMed  PubMed Central  Google Scholar 

  • Bukhari SI, Pattnaik B, Rayees S, Kaul S, Dhar MK (2015) Safranal of Crocus sativus L. inhibits inducible nitric oxide synthase and attenuates asthma in a mouse model of asthma. Phytother Res 29(4):617–627

    Article  PubMed  CAS  Google Scholar 

  • Bukhari SI, Manzoor M, Dhar MK (2018) A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids. Biomed Pharmacother 98:733–745

    Article  PubMed  CAS  Google Scholar 

  • Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (2012) Mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philos Trans R Soc Lond Ser B Biol Sci 367(1607):3364–3378

    Article  CAS  Google Scholar 

  • Cant’o C, Auwerx J (2012) Targeting sirtuin 1 to improve metabolism: all you need is NAD+? Pharmacol Rev 64(1):166–187

    Article  CAS  Google Scholar 

  • Carmeli C, Knyazeva MG, Cuénod M, Do KQ (2012) Glutathione precursor N-acetyl-cysteine modulates EEG synchronization in schizophrenia patients: a double-blind, randomized, placebo-controlled trial. PLoS One 7(2):e29341

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chen PW (2014) The treatment strategies for neurodegenerative diseases by integrative medicine. Integrat Med Int 1:223–225

    Article  Google Scholar 

  • Chengappa KN, Levine J, Gershon S, Mallinger AG, Hardan A, Vagnucci A, Pollock B, Luther J, Buttenfield J, Verfaille S, Kupfer DJ (2000) Inositol as an add-on treatment for bipolar depression. Bipolar Disord 2(1):47–55

    Article  PubMed  CAS  Google Scholar 

  • Chopra V, Quinti L, Kim J, Vollor L, Narayanan KL, Edgerly C, Lauver MA, Choi SH, Silverman RB, Ferrante RJ, Hersch S, Kazantsev AG (2012) The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models. Cell Res 2(6):1492–1497

    CAS  Google Scholar 

  • Chyan YJ, Poeggeler B, Omar RA (1999) Potent neuroprotective properties against the Alzheimer α-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid. J Biol Chem 31:21937–21942

    Article  Google Scholar 

  • Cole G, Teter B, Frautschy S (2007) Neuroprotective effects of curcumin. Adv Exp Med Biol 595:197–212

    Article  PubMed  PubMed Central  Google Scholar 

  • Conn PJ, Lindsley CW, Jones CK (2009) Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia. Trends Pharmacol Sci 30(1):25–31

    Article  PubMed  CAS  Google Scholar 

  • Covington HE, Maze I, LaPlant QC, Vialou VF, Ohnishi YN, Berton O, Fass DM, Renthal W, Rush AJ 3rd, Wu EY, Ghose S, Krishnan V, Russo SJ, Tamminga C, Haggarty SJ, Nestler EJ (2009) Antidepressant actions of histone deacetylase inhibitors. J Neurosci 29(37):11451–11460

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Crown WH, Finkelstein S, Berndt ER, Ling D, Poret AW, Rush AJ, Russell JM (2002) The impact of treatment-resistant depression on health care utilization and costs. J Clin Psychiatry 63:963–971

    Article  PubMed  Google Scholar 

  • Dai JN, Zong Y, Zhong LM, Li YM, Zhang W, Bian LG, Ai QL, Liu YD, Sun J, Lu D (2011) Gastrodin inhibits expression of inducible no synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. PLoS One 6(7):e21891

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dakhale GN, Khanzode SD, Khanzode SS, Saoji A (2005) Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia. Psychopharmacology 182(4):494–498

    Article  PubMed  CAS  Google Scholar 

  • Defeudis FV (2002) Bilobalide and neuroprotection. Pharmacol Res 46(6):565–568

    Article  PubMed  CAS  Google Scholar 

  • Devinsky O, Cilio MR, Cross H, Fernandez-Ruiz J, French J, Hill C, Katz R, Di Marzo V, Jutras-Aswad D, Notcutt WG, Martinez-Orgado J, Robson PJ, Rohrback BG, Thiele E, Whalley B, Friedman D (2014) Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia 55:791–802

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Eden Evins A, Demopulos C, Yovel I, Culhane M, Ogutha J, Grandin LD, Nierenberg AA, Sachs GS (2006) Inositol augmentation of lithium or valproate for bipolar depression. Bipolar Disord 8(2):168–174

    Article  PubMed  CAS  Google Scholar 

  • Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ (2013) Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology 64:81–96

    Article  PubMed  CAS  Google Scholar 

  • Fava M, Rush AJ, Wisniewski SR, Nierenberg AA, Alpert JE, McGrath PJ, Thase ME, Warden D, Biggs M, Luther JF, Niederehe G, Ritz L, Trivedi MH (2006) A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients a STAR∗D report. Am J Psychiatry 163:1161–1172

    Article  PubMed  Google Scholar 

  • FDA News Release (2018) FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy. June 25, 2018. https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-forms. Accessed 10 Oct 2019

  • Foley AG, Gannon S, Rombach-Mullan N, Prendergast A, Barry C, Cassidy AW, Regan CM (2012) Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder. Neuropharmacology 63(4):750–760

    Article  PubMed  CAS  Google Scholar 

  • Francis PT, Palmer AM, Snape M, Wilcock GK (1999) The cholinergic hypothesis of Alzheimer’s disease: a review of progress. J Neurol Neurosurg Psychiatry 66(2):137–147

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gao Y, Pu XP (2007) Neuroprotective effect of acteoside against rotenone-induced damage of SH-SY5Y cells and its possible mechanism. Chin Pharmacol Bull 23(2):161–165

    CAS  Google Scholar 

  • Garcia-Alloza M, Dodwell SA, Borrelli LA, Raju S, Bacskai BJ (2006) In vivo reduction of plaque size in APPswe/PS1D9 mice treated with curcumin (P4-342). Alzheimers Dement 2(3):S617

    Article  Google Scholar 

  • Ghanemi A (2015) Alzheimer’s disease therapies: selected advances and future perspectives. Alex J Med 51(1):1–3

    Article  Google Scholar 

  • Gohil KJ, Patel JA, Gajjar AK (2010) Pharmacological review on Centella asiatica: a potential herbal cure-all. Indian J Pharm Sci 72(5):546–556

    Article  PubMed  PubMed Central  Google Scholar 

  • Gräff J, Kahn M, Samiei A, Gao J, Ota KT, Rei D, Tsai LH (2013) A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci 33(21):8951–8960

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Greer TL, Kurian BT, Trivedi MH (2010) Defining and measuring functional recovery from depression. CNS Drugs 24:267–284

    Article  PubMed  CAS  Google Scholar 

  • Gueguen C, Palmier B, Plotkine M, Marchand-Leroux C, Besson VC (2014) Neurological and histological consequences induced by in vivo cerebral oxidative stress: evidence for beneficial effects of SRT1720, a sirtuin 1 activator, and sirtuin 1-mediated neuroprotective effects of poly(ADP-ribose) polymerase inhibition. PLoS One 9(2):e87367

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Habtemariam S (2011) The therapeutic potential of Berberis darwinii stem-bark: quantification of berberine and in vitro evidence for Alzheimer’s disease therapy. Nat Prod Commun 6(8):1089–1090

    PubMed  CAS  Google Scholar 

  • Habtemariam S (2017) Protective effects of Caffeic acid and the Alzheimer’s brain: an update. Mini Rev Med Chem 17(8):667–674

    Article  PubMed  CAS  Google Scholar 

  • Hait NC, Wise LE, Allegood JC, O’brien M, Avni D, Reeves TM, Knapp PE, Lu J, Luo C, Miles MF, Milstien S (2014) Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. Nat Neurosci 17(7):971–980

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hoane MR, Pierce JL, Kaufman NA, Beare JE (2008) Variation in chronic nicotinamide treatment after traumatic brain injury can alter components of functional recovery independent of histological damage. Oxidative Med Cell Longev 1(1):46–53

    Article  Google Scholar 

  • Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y (2010) Altered gene expression of histone deacetylases in mood disorder patients. J Psychiatr Res 44(5):263–270

    Article  PubMed  Google Scholar 

  • Holtzheimer PE, Mayberg HS (2011) Stuck in a rut rethinking depression and its treatment. Trends Neurosci 34:1–9

    Article  PubMed  CAS  Google Scholar 

  • Hu S, Han R, Mak S, Han Y (2011) Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. J Ethnopharmacol 35(1):34–42

    Article  CAS  Google Scholar 

  • Hyman SE, Fenton WS (2003) Medicine. What are the right targets for psychopharmacology? Science 299(5605):350–351

    Article  PubMed  CAS  Google Scholar 

  • Iriti M, Vitalini S, Fico G, Faoro F (2010) Neuroprotective herbs and foods from different traditional medicines and diets. Molecules 15(5):3517–3555

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Islam MT, Da-Silva CB, De-Alencar MVOB, Paz MFCJ, Almeida FRDC, Melo-Cavalcante AADC (2016) Diterpenes: advances in neurobiological drug research. Phytother Res 30(6):915–928

    Article  PubMed  Google Scholar 

  • Izzo AA, Borrelli F, Capasso R, Di Marzo V, Mechoulam R (2009) Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 30(10):515–527

    Article  PubMed  CAS  Google Scholar 

  • Jia H, Pallos J, Jacques V, Lau A, Tang B, Cooper A, Syed A, Purcell J, Chen Y, Sharma S, Sangrey GR (2012) Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington’s disease. Neurobiol Dis 46(2):351–361

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jochems J, Boulden J, Lee BG, Blendy JA, Jarpe M, Mazitschek R, Van Duzer JH, Jones S, Berton O (2014) Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability. Neuropsychopharmacology 39(2):389–400

    Article  PubMed  CAS  Google Scholar 

  • Kennedy DO, Scholey AB, Tildesley NT, Perry EK, Wesnes KA (2002) Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2(4):953–964

    Article  Google Scholar 

  • Kinon BJ, Dale KM, McKinzie DL (2008) mGlu2/3 receptor agonists: a new treatment approach for schizophrenia. Glutamate Neuropsychiatr Dis 8:147–155

    Google Scholar 

  • Kizuka Y, Kitazume S, Okahara K, Villagra A, Sotomayor EM, Taniguchi N (2014) Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers. J Biol Chem 289(16):11253–11261

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Koppel I, Timmusk T (2013) Differential regulation of Bdnf expression in cortical neurons by class-selective histone deacetylase inhibitors. Neuropharmacology 75:106–115

    Article  PubMed  CAS  Google Scholar 

  • Krieglstein J, Ausmeier F, El-Abhar H (1995) Neuroprotective effects of Ginkgo biloba constituents. Eur J Pharm Sci 3(1):39–48

    Article  CAS  Google Scholar 

  • Krystal JH, Perry EB Jr, Gueorguieva R, Belger A, Madonick SH, Abi-Dargham A, Cooper TB, MacDougall L, Abi-Saab W, D’Souza DC (2005) Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function. Arch Gen Psychiatry 62(9):985–994

    Article  PubMed  CAS  Google Scholar 

  • Kulkarni SK, Dhir A (2010) Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytother Res 24(3):317–324

    Article  PubMed  CAS  Google Scholar 

  • Kumar H, Kim IS, More SV, Kim BW, Bahk YY, Choi DK (2013) Gastrodin protects apoptotic dopaminergic neurons in a toxin-induced Parkinson’s disease model. Evid Based Complement Alternat Med 514095:1–13

    Article  Google Scholar 

  • Langlieb AM, Guico-Pabia CJ (2010) Beyond symptomatic improvement: assessing real-world outcomes in patients with major depressive disorder. Prim Care Companion J Clin Psychiatry 12:1–12

    Google Scholar 

  • Liu DZ, Xie KQ, Ji XQ, Ye Y, Jiang CL, Zhu XZ (2005) Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists. Br J Pharmacol 146(4):604–611

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Liu HQ, Zhang WY, Luo XT, Ye Y, Zhu XZ (2006) Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease by activation of adenosine A1 receptor. Br J Pharmacol 148(3):314–325

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lopez AD, Murray CC (1998) The global burden of disease, 1990–2020. Nat Med 4(11):1241–1243

    Article  PubMed  CAS  Google Scholar 

  • Lu L, Li X, Xu P, Zheng Y, Wang X (2017) Tenuigenin downregulates the release of nitric oxide, matrix metalloproteinase-9and cytokines from lipopolysaccharide-stimulated microglia. Neurosci Lett 650:82–88

    Article  PubMed  CAS  Google Scholar 

  • Maes M, Fišar Z, Medina M, Scapagnini G, Nowak G, Berk M (2012) New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors. Inflammopharmacology 20(3):127–150

    Article  PubMed  CAS  Google Scholar 

  • Magalhães PV, Dean OM, Bush AI, Copolov DL, Malhi GS, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M (2011) N-acetyl cysteine add-on treatment for bipolar II disorder: a subgroup analysis of a randomized placebo-controlled trial. J Affect Disord 29(1–3):317–320

    Article  CAS  Google Scholar 

  • Malvaez M, McQuown SC, Rogge GA, Astarabadi M, Jacques V, Carreiro S (2013) HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A 110(7):2647–2652

    Article  PubMed  PubMed Central  Google Scholar 

  • Marco EM, Garcia-Gutierrez MS, Bermudez-Silva FJ (2011) Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects. Front Behav Neurosci 5:63

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Marek GJ, Behl B, Bespalov AY, Gross G, Lee Y, Schoemaker H (2010) Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain? Mol Pharmacol 77(3):317–326

    Article  PubMed  CAS  Google Scholar 

  • Matsuda KI, Mori H, Nugent BM, Pfaff DW, McCarthy MM, Kawata M (2011) Histone deacetylation during brain development is essential for permanent masculinization of sexual behavior. Endocrinology 152(7):2760–2767

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • McKinzie D, Fell M, Knitowski K, Johnson B, Anderson W, Paulissen P, Perry K, Svensson K, Monn J (2011) Synergistic interactions of the mGlu2/3 receptor agonist LY404039 with antipsychotic agents in behavioral and neurochemical animal models predictive of antipsychotic efficacy. Presented at the international congress on schizophrenia research, Colorado Springs, CO, USA, April 2011

    Google Scholar 

  • McPartland JM, Duncan M, Di Marzo V, Pertwee RG (2015) Are cannabidiol and Δ(9)-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. Br J Pharmacol 172(3):737–753

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mechoulam R, Peters M, Murillo-Rodriguez E, Hanus LO (2007) Cannabidiol—recent advances. Chem Biodivers 4:1678–1692

    Article  PubMed  CAS  Google Scholar 

  • Michael S (2006) New directions for drug discovery. Dialogues Clin Neurosci 8(3):295–301

    Google Scholar 

  • Mielcarek M, Benn CL, Franklin SA, Smith DL, Woodman B, Marks PA (2011) SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington’s disease. PLoS One 6(11):e27746

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Miyasaka LS, Atallah AN, Soares BG (2006) Valerian for anxiety disorders. Cochrane Database Syst Rev 18(4):CD004515

    Google Scholar 

  • Mu X, He G, Cheng Y, Li X, Xu B, Du G (2009) Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Pharmacol Biochem Behav 92(4):642–648

    Article  PubMed  CAS  Google Scholar 

  • Nabavi SF, Habtemariam S, Jafari M, Sureda A, Nabavi SM (2012) Protective role of gallic acid on sodium fluoride induced oxidative stress in rat brain. Bull Environ Contam Toxicol 89(1):73–77

    Article  PubMed  CAS  Google Scholar 

  • Nabavi SF, Habtemariam S, Lorenzo AD, Sureda A, Khanjani S, Nabavi SA, Daglia M (2016) Post-stroke depression modulation and in vivo antioxidant activity of gallic acid and its synthetic derivatives in a murine model system. Nutrients 8(5):248

    Article  PubMed Central  CAS  Google Scholar 

  • Nieoullon A (2011) Neurodegenerative diseases and neuroprotection: current views and prospects. J Appl Biomed 9(4):173–183

    Article  Google Scholar 

  • Oehme I, Linke JP, Böck BC, Milde T, Lodrini M, Hartenstein B, Wiegand I, Eckert C, Roth W, Kool M, Kaden S, Gröne HJ, Schulte JH, Lindner S, Hamacher-Brady A, Brady NR, Deubzer HE, Witt O (2013) Histone deacetylase 10 promotes autophagy-mediated cell survival. Proc Natl Acad Sci U S A 110(28):E2592–E2601

    Article  PubMed  PubMed Central  Google Scholar 

  • Ojha RP, Rastogi M, Devi BP, Agrawal A, Dubey GP (2012) Neuroprotective effect of curcuminoids against inflammation mediated dopaminergic neurodegeneration in the mptp model of Parkinson’s disease. J Neuroimmune Pharmacol 7(3):609–618

    Article  PubMed  Google Scholar 

  • Ookubo M, Kanai H, Aoki H, Yamada N (2013) Antidepressants and mood stabilizers effects on histone deacetylase expression in C57BL/6 mice: brain region specific changes. J Psychiatr Res 47(9):1204–1214

    Article  PubMed  Google Scholar 

  • Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG (2007) Sirtuin 2 inhibitors rescue ǖFC;-synuclein-mediated toxicity in models of Parkinson’s disease. Science 317(5837):516–519

    Article  PubMed  CAS  Google Scholar 

  • Pan J, Li H, Ma JF (2012) Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease through suppressing mitochondria dysfunction. Transl Neurodegener 1:16

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Petersen T, Gordon JA, Kant A, Fava M, Rosenbaum JF, Nierenberg AA (2001) Treatment resistant depression and axis i co-morbidity. Psychol Med 31:1223–1239

    Article  PubMed  CAS  Google Scholar 

  • Phukan J, Hardiman O (2009) The management of amyotrophic lateral sclerosis. J Neurol 256(2):176–186

    Article  PubMed  Google Scholar 

  • Rayees S, Malik F (2017) Withania somnifera: from traditional use to evidence based medicinal prominence. In: Science of Ashwagandha: preventive and therapeutic potentials. Springer, Cham, pp 81–103

    Chapter  Google Scholar 

  • Rayees S, Johri R, Singh G, Tikoo M, Singh S, Sharma S, Satti N, Gupta V, Bedi Y (2012) Sitopaladi, a poly-herbal formulation inhibits IgE mediated allergic reactions. Spatula DD - Peer Rev J Complement Med Drug Discov 2(2):75

    Google Scholar 

  • Rayees S, Johri RK, Singh G, Tikoo MK, Singh S, Sharma SC, Satti NK, Gupta VK, Bedi YS (2013a) Sitopaladi, a poly-herbal formulation inhibits IgE mediated allergic reactions. Spatula DD 2:75–82

    Article  Google Scholar 

  • Rayees S, Kumar A, Rasool S, Kaiser P, Satti NK, Sangwan PL, Singh S, Johri RK, Singh G (2013b) Ethanolic extract of Alternanthera sessilis (AS-1) inhibits IgE-mediated allergic response in RBL-2H3 cells. Immunol Investig 42:470–480

    Article  Google Scholar 

  • Rayees S, Sharma R, Rohit S, Singh G, Najar IA, Singh A, Ahamad DB, Sharma SC (2013c) Acute, sub-acute and general pharmacological evaluation of 5-(3,4-methylenedioxyphenyl)-4-ethyl-2E,4E-pentadienoic acid piperidide (SK-20): a novel drug bioavailability enhancer. Environ Toxicol Pharmacol 35(2):347–359

    Article  PubMed  CAS  Google Scholar 

  • Rayees S, Satti NK, Mehra R, Nargotra A, Rasool S, Sharma A, Sahu PK, Vivek KG, Nepali K, Singh G (2014) Anti-asthmatic activity of azepino [2, 1-b] quinazolones, synthetic analogues of vasicine, an alkaloid from Adhatoda vasica. Med Chem Res 23(9):4269–4279

    Article  CAS  Google Scholar 

  • Rayees S, Mabalirajan U, Bhat WW, Rasool S, Rather RA, Panda L, Satti NK, Lattoo SK, Ghosh B, Singh G (2015) Therapeutic effects of R8, a semi-synthetic analogue of Vasicine, on murine model of allergic airway inflammation via STAT6 inhibition. Int Immunopharmacol 26(1):246–256

    Article  PubMed  CAS  Google Scholar 

  • Regitz C, Dußling LM, Wenzel U (2014) Amyloid-beta (Aα1-42)-induced paralysis in Caenorhabditis elegans is inhibited by the polyphenol quercetin through activation of protein degradation pathways. Mol Nutr Food Res 58(10):1931–1940

    Article  PubMed  CAS  Google Scholar 

  • Robson PJ, Guy GW, Di Marzo V (2014) Cannabinoids and schizophrenia: therapeutic prospects. Curr Pharm Des 20:2194–2204

    Article  PubMed  CAS  Google Scholar 

  • Rolland A, Fleurentin J, Lanhers MC, Misslin R, Mortier F (2001) Neurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae). Phytother Res 15(5):377–381

    Article  PubMed  CAS  Google Scholar 

  • Rudenko A, Tsai LH (2014) Epigenetic modifications in the nervous system and their impact upon cognitive impairments. Neuropharmacology 80:70–82

    Article  PubMed  CAS  Google Scholar 

  • Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D (2006) Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR∗D report. Am J Psychiatry 163(11):1905–1917

    Article  PubMed  Google Scholar 

  • Salmi M, Bruneau N, Cillario J, Lozovaya N, Massacrier A, Buhler E (2013) Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero. Brain 136(8):2457–2473

    Article  PubMed  Google Scholar 

  • Sarkar A, Chachra P, Kennedy P, Pena CJ, Desouza LA, Nestler EJ, Vaidya VA (2014) Hippocampal HDAC4 contributes to postnatal fluoxetine-evoked depression-like behavior. Neuropsychopharmacology 39(9):2221–2232

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sarris J (2007) Herbal medicines in the treatment of psychiatric disorders: a systematic review. Phytother Res 21:703–716

    Article  PubMed  Google Scholar 

  • Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM (2013) A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. PLoS One 8(8):e71323

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Schuetz A, Min J, Antoshenko T, Wang CL, Allali-Hassani A, Dong A (2007) Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin. Structure 15(3):377–389

    Article  PubMed  CAS  Google Scholar 

  • Selkoe DJ (2001) Alzheimer’s disease: genes, proteins, and therapy. Physiol Rev 81(2):741–766

    Article  PubMed  CAS  Google Scholar 

  • Serafini G, Pompili M, Innamorati M, Dwivedi Y, Brahmachari G, Girardi P (2013) Pharmacological properties of glutamatergic drugs targeting NMDA receptors and their application in major depression. Curr Pharm Des 19:1898–1922

    Article  PubMed  CAS  Google Scholar 

  • Serafini G, Howland RH, Rovedi F, Girardi P, Amore M (2014) The role of ketamine in treatment-resistant depression: a systematic review. Curr Neuropharmacol 12(5):444–461

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Shein NA, Shohami E (2011) Histone deacetylase inhibitors as therapeutic agents for acute central nervous system injuries. Mol Med 17(5–6):448–456

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Shevtsov VA, Zholus BI, Shervarly VI, Vol’skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G (2003) A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 10(2–3):95–105

    Article  PubMed  CAS  Google Scholar 

  • Smith PF, Maclennan K, Darlington CL (1996) The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). J Ethnopharmacol 50(3):131–139

    Article  PubMed  CAS  Google Scholar 

  • Soleimani L, Lapidus KA, Iosifescu DV (2011) Diagnosis and treatment of major depressive disorder. Neurol Clin 9(1):177–199

    Article  Google Scholar 

  • Spedding M, Jay T, Costa e Silva J, Perret L (2005) A pathophysiological paradigm for the therapy of psychiatric disease. Nat Rev Drug Discov 4(6):467–476

    Article  PubMed  CAS  Google Scholar 

  • Sun AY, Wang Q, Simonyi A, Sun GY (2010) Resveratrol as a therapeutic agent for neurodegenerative diseases. Mol Neurobiol 41(2):375–383

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Swamy MK, Arumugam G, Kaur R, Ghasemzadeh A, Yusoff MM, Sinniah UR (2017) GC-MS based metabolite profiling, antioxidant and antimicrobial properties of different solvent extracts of Malaysian Plectranthus amboinicus leaves. Evid Based Complement Alternat Med 2017:1517683. https://doi.org/10.1155/2017/1517683

  • Taber KH, Hurley RA, Yudofsky SC (2010) Diagnosis and treatment of neuropsychiatric disorders. Annu Rev Med 61:121–133

    Article  PubMed  CAS  Google Scholar 

  • Taylor DM, Balabadra U, Xiang Z, Woodman B, Meade S, Amore A (2011) A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem Biol 6(6):540–546

    Article  PubMed  CAS  Google Scholar 

  • Thomas EA, Coppola G, Desplats PA, Tang B, Soragni E, Burnett R, Gao F, Fitzgerald KM, Borok JF, Herman D, Geschwind DH, Gottesfeld JM (2008) The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington’s disease transgenic mice. Proc Natl Acad Sci U S A 105(40):15564–15569

    Article  PubMed  PubMed Central  Google Scholar 

  • Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9(4):519–525

    Article  PubMed  CAS  Google Scholar 

  • Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, Suzuki T, Miyata N, Watanabe Y (2011) Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Neuron 69(2):359–372

    Article  PubMed  CAS  Google Scholar 

  • Valle-Mojica LMD, Ayala-Marín YM, Ortiz-Sanchez CM, Torres-Hernández BA, Abdalla-Mukhaimer S, Ortiz JG (2011) Selective interactions of Valeriana officinalis extracts and Valerenic acid with [3H]glutamate binding to rat synaptic membranes. Evid Based Complement Alternat Med 2011:1–7

    Google Scholar 

  • Vollenweider FX, Vontobel P, Oye I, Hell D, Leenders KL (2000) Effects of (S)-ketamine on striatal dopamine: a [11C]raclopride PET study of a model psychosis in humans. J Psychiatr Res 34(1):35–43

    Article  PubMed  CAS  Google Scholar 

  • Wang LJ, Xiong J, Liu ST, Liu XH, Hu JF (2014) Sesquiterpenoids from chloranthus henryi and their anti-neuroinflammatory activities. Chem Biodivers 11(6):919–928

    Article  PubMed  CAS  Google Scholar 

  • Wang H, Miao Y, Mir AZ (2016) Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathway in SH-SY5Y cells. J Neurol Sci 368:223–230

    Article  PubMed  CAS  Google Scholar 

  • Wheatley D (2001) Kava and valerian in the treatment of stress-induced insomnia. Phytother Res 5(6):549–551

    Article  Google Scholar 

  • WHO (2004) WHO guidelines on safety monitoring of herbal medicines in Pharmacovigilance systems. World Health Organization, Geneva

    Google Scholar 

  • Wijesekera LC, Leigh PN (2009) Amyotrophic lateral sclerosis. Orphanet J Rare Dis 4(1):3

    Article  PubMed  PubMed Central  Google Scholar 

  • Wu J, Maoqiang L, Fan H (2016) Rutin attenuates neuroinflammation in spinal cord injury rats. J Surg Res 203(2):331–337

    Article  PubMed  CAS  Google Scholar 

  • Xu L, Chen WF, Wong MS (2009) Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson’s disease through the IGF-I receptor signaling pathway. Br J Pharmacol 158(3):738–748

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Xu J, Guo Y, Zhao P, Xie C, Jin DQ, Hou W, Zhang TP (2011) Neuroprotective cadinene sesquiterpenes from the resinous exudates of Commiphora myrrha. Fitoterapia 82(8):1198–1201

    Article  PubMed  CAS  Google Scholar 

  • Yang YC, Chen CN, Wu CI, Huang WJ, Kuo TY, Kuan MC (2013) NBM-T-L-BMX-OS01, Semisynthesized from Osthole, is a novel inhibitor of histone Deacetylase and enhances learning and memory in rats. Evid Based Complement Alternat Med 2013:514908

    PubMed  PubMed Central  Google Scholar 

  • Yeh HH, Tian M, Hinz R, Young D, Shavrin A, Mukhapadhyay U (2013) Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with 18F-FAHA. Neuroimage 64:630–639

    Article  PubMed  CAS  Google Scholar 

  • Zabaiou N, Fouache A, Trousson A, Baron S, Zellagui A, Lahouel M, Lobaccaro JA (2017) Biological properties of propolis extracts: something new from an ancient product. Chem Phys Lipids 207:214–222

    Article  PubMed  CAS  Google Scholar 

  • Zhao YN, Li WF, Li F, Zhang Z, Dai YD, Xu AL (2013) Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway. Biochem Biophys Res Commun 435(4):597–602

    Article  PubMed  CAS  Google Scholar 

  • Zhu G, Wang X, Wu S, Li Q (2012) Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. Neurochem Int 60(4):400–408

    Article  PubMed  CAS  Google Scholar 

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Din, I., Anwar, M., Rayees, S., Malik, F. (2020). Traditional Plant Compounds for the Treatment of Neuropsychiatric Disorders. In: Swamy, M. (eds) Plant-derived Bioactives. Springer, Singapore. https://doi.org/10.1007/978-981-15-1761-7_18

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