Impact of Cranial Electrical Stimulation Based Analysis of Heart Rate Variability in Insomnia

  • KhyateeEmail author
  • Aparna Sarkar
  • Rajeev Aggarwal
Conference paper
Part of the Communications in Computer and Information Science book series (CCIS, volume 922)


Insomnia is primary care in medical world. Impaired sleep quantity and quality is linked with an increased risk of cardio vascular diseases, as it is crosslinked to anxiety, depression, state of confusion and stress. They act as cofactor for disturbed sympatho vagal balance and sympathetic dominance. We conducted a study to analyze Heart rate variability and sleep quality in Insomnia subjects and assessed impact of Cranial Electrical Stimulation on them. Forty subjects were recruited in the study including males and females between age Cluster 18 years to 44 years suffering from Insomnia (sleep < 6 h) were divided into two Clusters, Cluster A (Control N = 20) and Cluster B (Experimental N = 20). Cranial Electrical stimulation (ALPHA STIM AID) was given to Cluster B for 21 days (5 days per week) and duration 20 min per day. Heart rate variability was measured by Physio Pack (Kubios 2.1) and quality of sleep was measured by (PSQI). Statistically significant differences were found in Cluster B comparison with Cluster A in Statistical and Geometric indices of Time Domain Factors like STDHR, SDNN, RMSSD, RR Tri, TINN with p value (p < 0.025), (p < 0.047), (p < 0.048), (p < 0.037), (p < 0.047) respectively. In Frequency Domain Factors statistically significant differences were found in VLF, HF, Total Power with p value (p < 0.032), (p < 0.044), (p < 0.045)respectively. There was significant difference in Global Pittsburg Sleep Quality Score with (p < 0.05) in Cluster B and Cluster A. Heart Rate variability, sleep quality and quantity were significantly higher in Insomnia subjects of Cluster B comparison with Cluster A after receiving Cranial Electrical stimulation.


Cranial electrical stimulation Heart rate variability Insomnia 


  1. 1.
    Tobaldini, E., Nobili, L., Strada, S., Casali, K.R., Braghiroli, A., Montano, N.: Heart rate variability in normal and pathological sleep. Front. Physiol. 4, 294 (2013). Scholar
  2. 2.
    Lichtbroun, A.S., Raicer, M.M.C., Smith, R.B.: The treatment of fibromyalgia with cranial electrical stimulation. J. clin. Rheumatol. 7(2), 72–78 (2001)CrossRefGoogle Scholar
  3. 3.
    Kirsch, D.L., Smith, R.B.: The use of cranial electrical stimulation in management of chronic pain: A review. Neurorehabilitation 14(2), 85–94 (2000)Google Scholar
  4. 4.
    Thuile, C., Kirsch, D.L.: Schnerzen Linden OhneChennieCES, die Revolution in der Schnerztherapie. IGEM (2000)Google Scholar
  5. 5.
    Parkway, G.M.: Mineral wells. Psychiatr. clin. N. Am. 36, 169–176 (2013). 2201CrossRefGoogle Scholar
  6. 6.
    Krsch, D.L., Nichols, F.: Cranial electrical stimulation treatment of anxiety, depression and insomnia. Psychiatr. clin. N. Am. 36, 169–176 (2013)CrossRefGoogle Scholar
  7. 7.
    Ohayon, M.M.: Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med. Rev. 6, 97–111 (2002)CrossRefGoogle Scholar
  8. 8.
    McGrath, E.R., et al.: Sleep to lower elevated blood pressure: a randomized controlled trial (SLEPT). Am. J. Hypertens. 30(3), 319–327 (2017). Scholar
  9. 9.
    Bikson, M., et al.: Limited output transcranial electrical stimulation (LOTES-2017): engineering principles, regulatory statues, and industry standards for wellness, over the counter, or prescription devices with low risk. Brain stimulation 11, 134–157 (2018)CrossRefGoogle Scholar
  10. 10.
    Kanai, R., Chaieb, L., Antal, A., Walsh, V., Paulus, W.: Frequency-dependent electrical stimulation of the visual cortex. Curr. Biol. 18(23), 1839–1843 (2008). Scholar
  11. 11.
    Boggio, P.S., Ferrucci, R., Rigonatti, S.P., Covre, P., Nitsche, M., Pascual-Leone, A., et al.: Effects of transcranial direct current stimulation on working memory in patients with Parkinson’s disease. J. Neurol. Sci. 249(1), 31–38 (2006). Scholar
  12. 12.
    Weber, M.J., Messing, S.B., Rao, H., Detre, J.A., Thompson-Schill, S.L.: Prefrontal transcranial direct current stimulation alters activation and connectivity in cortical and subcortical reward systems: a tDCS-fMRI study. Hum Brain Mapp 35(8), 3673–3686 (2014). Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Amity Institute of Physiotherapy, Amity UniversityNoidaIndia
  2. 2.Amity Institute of Physiology and Allied SciencesAmity UniversityNoidaIndia
  3. 3.AIIMS, Neuro-Physiotherapy UnitNSC A.I.I.M.S.New DelhiIndia

Personalised recommendations