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Y RNAs: Biogenesis, Function and Implications for the Cardiovascular System

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Non-coding RNAs in Cardiovascular Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1229))

Abstract

In recent years, progress in the field of high-throughput sequencing technology and its application to a wide variety of biological specimens has greatly advanced the discovery and cataloging of a diverse set of non-coding RNAs (ncRNAs) that have been found to have unexpected biological functions. Y RNAs are an emerging class of highly conserved, small ncRNAs. There is a growing number of reports in the literature demonstrating that Y RNAs and their fragments are not just random degradation products but are themselves bioactive molecules. This review will outline what is currently known about Y RNA including biogenesis, structure and functional roles. In addition, we will provide an overview of studies reporting the presence and functions attributed to Y RNAs in the cardiovascular system.

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Acknowledgements

SD is funded by RO1 HL122547 and AHA SFRN grant.

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The authors declare no competing financial interests.

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  1. Cardiovascular Research Center of Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Nedyalka Valkov & Saumya Das

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  1. Nedyalka Valkov
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  1. Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China

    Junjie Xiao

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Valkov, N., Das, S. (2020). Y RNAs: Biogenesis, Function and Implications for the Cardiovascular System. In: Xiao, J. (eds) Non-coding RNAs in Cardiovascular Diseases. Advances in Experimental Medicine and Biology, vol 1229. Springer, Singapore. https://doi.org/10.1007/978-981-15-1671-9_20

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