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Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetics for Biomedical Application

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Nanozymology

Part of the book series: Nanostructure Science and Technology ((NST))

Abstract

Iron oxide nanoparticles have been widely used in many important fields due to excellent nanoscale physical properties such as magnetism/superparamagnetism, and they are usually assumed biological inert. However, in the last few years, iron oxide nanoparticles were surprisingly found with intrinsic enzyme-like activities and are now widely regarded as novel enzyme mimetics. A specified term, “Nanozyme”, has been coined to define the new property for intrinsic enzymatic activities of nanomaterials. Since then, iron oxide nanoparticles have been used as nanozyme to facilitate their biomedical applications . In this review, we will systematically introduce the enzymatic features of iron oxide nanozyme (IONzyme) and summarize the extended novel applications based on the intrinsic enzyme-like activities .

The content in this chapter has been published on Theranostics and reformatted in this book.

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Abbreviations

ABTS:

2, 2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)

DAB:

3, 3′-Diaminobenzidine

DMSA:

Dimercaptosuccinic acid

DNA:

Deoxyribonucleic acid

ELISA:

Enzyme-linked immunosorbent assay

ESR:

Electron spin resonance

GO:

Graphene oxide

GOx:

Glucose oxidase

HRP:

Horseradish peroxidase

ION:

Zyme iron oxide nanozyme

MRI:

Magnetic resonance imaging

MNPs:

Magnetic nanoparticles

OPD:

o-phenylenediamine

ROS:

Reactive oxygen species

SPIO:

Superparamagnetic iron oxide

TA:

Terephthalic acid

TMB:

3, 3′, 5, 5′-Tetramethylbenzidine

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Acknowledgements

This work was supported by Young Elite Scientist Sponsorship Program by the National Key R&D Program of China (Grant No. 2018YFC1003500), CAST, Beijing Natural Science Foundation (Grant No. 5164037), China Postdoctoral Science Foundation (Grant No. 2015M570158) and the China Postdoctoral Science Special Foundation (Grant No. 2016T90143), Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA09030306), National Natural Science Foundation of China (Grant No. 81930050, 31530026 and 81671810), Key Research Program of Frontier Sciences, CAS (Grant No. QYZDB-SSW-SMC013), and Natural Science Foundation of Jiangsu, China (BK20161333).

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  1. CAS Engineering Laboratory for Nanozyme. Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing, 100101, China

    Lizeng Gao, Kelong Fan & Xiyun Yan

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  1. Lizeng Gao
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  2. Kelong Fan
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Correspondence to Lizeng Gao .

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  1. CAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

    Xiyun Yan

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Gao, L., Fan, K., Yan, X. (2020). Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetics for Biomedical Application. In: Yan, X. (eds) Nanozymology. Nanostructure Science and Technology. Springer, Singapore. https://doi.org/10.1007/978-981-15-1490-6_5

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