Pharmacogenetics in Cancer Treatment: Challenges and Recent Trends
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Cancer is a genetic disorder of the genome leading from different types of genetic mutations. Cancer genomics has improved the cancer pathogenesis leading toward potential future therapeutics. Advanced techniques like next-generation sequencing-based testing of carcinomas offer new insights into endometrial carcinogens and opportunities for improved tumor surveillance, diagnosis, and management. Novel strategies target the microbial genome for therapeutic drives by which adapted medicines can be generated for curing many types of cancers. Further advancements are required in genome-based technologies, such as high-throughput innovations, improvement of gene expression arrays, and functionally significant candidate genes. Transgenic and knockout approaches could likewise be used for setting up the key components that helps in drug response against cancer. But further research is needed from larger cancer populations along with validated pharmacogenetic markers prior to application in diagnostics.
KeywordsCancer pathogenesis High-throughput innovations Gene expression arrays Drug resistance Personalized medicine
- 4.Saha SK, Islam SR, Kwak KS et al (2019) PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis. Cancer Gene Ther. https://doi.org/10.1038/s41417-019-0109-7
- 12.Schork NJ (2019) Artificial intelligence and personalized medicine. In: Precision medicine in cancer therapy, Springer, Cham, pp 265–283Google Scholar
- 14.Rajpoot M, Sharma AK, Sharma A et al (2018) Understanding the microbiome: emerging biomarkers for exploiting the microbiota for personalized medicine against cancer. In: Seminars in cancer biology, vol 52. Elsevier, New York, pp 1–8Google Scholar
- 25.Ruwali M (2019) Pharmacogenetics and cancer treatment: progress and prospects. In: Molecular medicine. IntechOpen, RijekaGoogle Scholar