Skip to main content

Deep Learning for Classifying of White Blood Cancer

  • Conference paper
  • First Online:
ISBI 2019 C-NMC Challenge: Classification in Cancer Cell Imaging

Part of the book series: Lecture Notes in Bioengineering ((LNBE))

Abstract

Cell classification by computer assistant technique has become a popular topic recently. It is crucial to do early disease diagnosis with less cost. In order to find efficient, high accuracy computer assistant methods, The International Symposium on Biomedical Imaging (ISBI) held the classification of normal vs malignant cells (C-NMC) challenge 2019 for classifying B-ALL white blood cancer microscopic images. Our team deploys several state-of-the-art CNN architectures and uses an ensemble method named stacking to boost the final prediction performance, which helped to get the eighth place in the preliminary phase and tenth place in the final phase. Weighted F1 scores evaluated on our model were 0.8674 and 0.8552, for the preliminary and final phase, respectively. It is a relatively reasonable result in such an expertise required task.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Pui, C.H.: Acute lymphoblastic leukemia. Pediatr. Clin. North Am. 44(4), 831 (1997)

    Article  CAS  Google Scholar 

  2. Nazlibilek, S., Karacor, D., Ercan, T., et al.: Automatic segmentation, counting, size determination and classification of white blood cells. Measurement 55, 58–65 (2014)

    Article  Google Scholar 

  3. Wang, D., Khosla, A., Gargeya, R., et al.: Deep learning for identifying metastatic breast cancer (2016)

    Google Scholar 

  4. Grewal, M., Srivastava, M.M., Kumar, P., et al.: RADNET: radiologist level accuracy using deep learning for HEMORRHAGE detection in CT scans (2017)

    Google Scholar 

  5. Esteva, A., Kuprel, B., Novoa, R.A., et al.: Dermatologist-level classification of skin cancer with deep neural networks. Nature 542(7639), 115–118 (2017)

    Article  CAS  Google Scholar 

  6. Kamnitsas, K., Ledig, C., Newcombe, V.F.J., et al.: Efficient multi-scale 3D CNN with fully connected CRF for accurate brain lesion segmentation. Med. Image Anal. (2016). S1361841516301839

    Google Scholar 

  7. Voets, M., Møllersen, K., Bongo, L.A.: Replication study: development and validation of deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs (2018)

    Google Scholar 

  8. Rajpurkar, P., Hannun, A.Y., Haghpanahi, M., et al.: Cardiologist-level Arrhythmia detection with convolutional neural networks (2017)

    Google Scholar 

  9. Duggal, R., Gupta, A., Gupta, R., Wadhwa, M., Ahuja, C.: Overlapping cell nuclei segmentation in microscopic images using deep belief networks. In: Indian Conference on Computer Vision, Graphics and Image Processing (ICVGIP), India, December 2016

    Google Scholar 

  10. Duggal, R., Gupta, A., Gupta, R.: Segmentation of overlapping/touching white blood cell nuclei using artificial neural networks. CME Series on Hemato-Oncopathology, All India Institute of Medical Sciences (AIIMS), New Delhi, India, July 2016

    Google Scholar 

  11. Duggal, R., Gupta, A., Gupta, R., Mallick, P.: SD-layer: stain deconvolutional layer for CNNs in medical microscopic imaging. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D., Duchesne, S. (eds.) Medical Image Computing and Computer-Assisted Intervention, MICCAI 2017. Lecture Notes in Computer Science, Part III, LNCS 10435, pp. 435–443. Springer, Cham. https://doi.org/10.1007/978-3-319-66179-7_50

    Chapter  Google Scholar 

  12. Deng, J., Dong, W., Socher, R., et al.: ImageNet: a large-scale hierarchical image database. In: 2009 IEEE Conference on Computer Vision and Pattern Recognition. IEEE (2009)

    Google Scholar 

  13. Rajpurkar, P., Irvin, J., Zhu, K., et al.: CheXNet: radiologist-level pneumonia detection on chest X-rays with deep learning (2017)

    Google Scholar 

  14. Deng, L., Yu, D.: Deep learning: methods and applications. Found. Trends Signal Process. 7(3), 197–387 (2014)

    Article  Google Scholar 

  15. Gupta, A., Duggal, R., Gupta, R., Kumar, L., Thakkar, N., Satpathy, D.: GCTI-SN: Geometry-Inspired Chemical and Tissue Invariant Stain Normalization of Microscopic Medical Images. Under review

    Google Scholar 

  16. Gupta, R., Mallick, P., Duggal, R., Gupta, A., Sharma, O.: Stain color normalization and segmentation of plasma cells in microscopic images as a prelude to development of computer assisted automated disease diagnostic tool in multiple Myeloma. In: 16th International Myeloma Workshop (IMW), India, March 2017

    Google Scholar 

  17. Szegedy, C., Vanhoucke, V., Ioffe, S., Shlens, J., Wojna, Z.: Rethinking the inception architecture for computer vision. In: CVPR (2016)

    Google Scholar 

  18. Huang, G., Liu, Z., Weinberger, K.Q., Maaten, L.: Densely connected convolutional networks. In: CVPR (2017)

    Google Scholar 

  19. Szegedy, C., Ioffe, S., Vanhoucke, V.: Inception-v4, Inception-ResNet and the impact of residual connections on learning. In: CoRR (2016). arXiv:1602.07261

  20. Breiman, L.: Stacked regressions. Mach. Learn. 24(1), 49–64 (1996)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yan Cui .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Ding, Y., Yang, Y., Cui, Y. (2019). Deep Learning for Classifying of White Blood Cancer. In: Gupta, A., Gupta, R. (eds) ISBI 2019 C-NMC Challenge: Classification in Cancer Cell Imaging. Lecture Notes in Bioengineering. Springer, Singapore. https://doi.org/10.1007/978-981-15-0798-4_4

Download citation

Publish with us

Policies and ethics