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Selective Autophagy Regulates Innate Immunity Through Cargo Receptor Network

  • Yaoxing Wu
  • Jun CuiEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1209)

Abstract

Autophagy, an evolutionarily conserved cargo degradation process, is responsible to remove superfluous and unwanted cytoplasmic materials and maintain cellular homeostasis. Autophagy can be highly selective and target specific cargoes by utilizing multiple cargo receptors, which bind both ubiquitinated cargoes and autophagosomes. Mounting evidence has revealed the deep involvement of selective autophagy in innate immunity upon pathogen invasion, including eliminating microbial pathogens, initiating the anti-microbe responses, and inhibiting excessive immune responses. Given the importance of selective autophagy in innate immunity, how cargo receptors deliver pathogens and intracellular host constitutes to autophagosomes during infection remains to be elucidated. In this review, we summarize current evidence for the regulation of innate immunity by selective autophagy and try to elucidate the mechanisms employed by cargo receptor network in mediating diverse innate immune responses.

Keywords

Selective autophagy Cargo receptor Ubiquitination Immune response 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (31870862, 31700760, and 31800751), Science and Technology Planning Project of Guangzhou, China (201804010385), and the Fundamental Research Funds for the Central Universities (18lgpy53).

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life SciencesSun Yat-sen UniversityGuangzhouChina

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