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Autophagy Regulation of Mammalian Immune Cells

  • Wenzhuo He
  • Wenjing Xiong
  • Xiaojun XiaEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1209)

Abstract

Autophagy is a fully competent cellular machinery able to carry out the clearance of macromolecules via fusion with the lysosome. Many studies conducted in recent years have revealed that autophagy not only plays a critical role in maintaining cell homeostasis, but can also promote bacterial elimination. Additionally, autophagy exists in most eukaryotic cells including immune cells, such as lymphocytes, neutrophils, eosinophils, mast cells, and natural killer cells. Presently, there are numerous studies focusing on the roles of autophagy in regulating immune response. Autophagy regulates the innate and adaptive immunity by modulating cell differentiation, survival, phagocytosis, antigen presentation, degranulation, and cytokine production. In this chapter, we will summarize how autophagy participates explicitly in the survival and function of the mammalian adaptive and innate immune cells.

Keywords

Autophagy Immune cells Lymphocyte Neutrophil Macrophage Dendritic cell Natural killer cell 

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina
  2. 2.VIP RegionSun Yat-sen University Cancer CenterGuangzhouChina

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