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Regulation of ATG and Autophagy Initiation

  • Wen Li
  • Lining ZhangEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1206)

Abstract

ATG is involved in multiple processes of autophagosome formation, including the initial phase of autophagy. The mammalian autophagy complex-ULK1 complex is composed of ULK1, FIP200, ATG13 and ATG101, and the yeast autophagy initiation complex-ATG1 complex is composed of ATG1, ATG13, ATG17, ATG29 and ATG31. After this complex is activated, it binds and phosphorylates ATG9 on the vesicles. Then PI3KC3-C1 (yeast: ATG34: ATG15: ATG6: ATG14 or mammal animal: ATG34: ATG15: BECN1: ATG14L) is recruited to the PAS. Further, ATG12-ATG5-ATG16 complex is localized on PAS (Yeast) or localized on the outer surface of the membrane (mammal) and makes binding of ATG8 (LC3) with PE to form ATG8-PE complex, promoting autophagic membrane elongation, closure and formation autophagosome and autophagosome lysosome.

Keywords

ULK1/ATG1 complex PI3KC3-C1 compounds ATG8(LC3) ATG9 

Abbreviations

GABARAP

Γ-aminobutyric acid receptor-associated protein

GATE-16

Golgi-associated ATPase enhancer

Golgi v-SNARE

Golgi vesicle-associated N-ethylmaleimide-sensitive factor attachment protein receptor

PE

Phosphatidylethanolamine

PI

Phosphatidylinositol phosphatidylinositol

PI3P

Phosphatidylinositol 3-phosphate

SNARE

Soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor

MAP1LC3

Microtubule-associated protein 1 light-chain 3

NSF

N-ethylmaleimide-sensitive factor

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Copyright information

© Science Press and Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Immunology, School of Basic Medical ScienceShandong UniversityJinanChina

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