Autophagy and the Metabolism of Misfolding Protein

  • Chao ChengEmail author
  • Zhen-Guo Liu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1206)


Autophagy is a major intracellular degradative process that delivers cytoplasmic materials to the lysosome for degradation. An increasing number of studies on the physiological and pathological roles of autophagy in a variety of autophagy knockout models and human diseases were carried out. Among them, the clearance of misfolded proteins is the important function of autophagy. Impairment at different steps of the autophagy system, such as the ubiquitin-proteasome and the autophagy-lysosome pathways, may result in the accumulation of misfolded proteins in insoluble aggregates. Abnormal accumulation of misfolded proteins in cells can lead to a variety of human diseases. Here, we review the major advances in autophagy and the metabolism of misfolding protein in human diseases. Current studies about the promising therapeutic strategy in autophagy-modulating are also summarized.


Autophagy Misfolding protein Metabolism Aggregation 


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Copyright information

© Science Press and Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Thoracic SurgeryThe First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouPeople’s Republic of China

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