Advertisement

The Role of Nanomaterials in Autophagy

  • Min Wei
  • Wei-Dong LeEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1206)

Abstract

With the development of nanotechnology and the emergence of new nanomaterials, the effect of nanomaterials on autophagy regulation has attracted increasing attention. Nanomaterial-mediated autophagy regulation has potential applications in the diagnosis and treatment of autophagy-related diseases, such as cancer treatment, drug sensitization and neurodegenerative diseases. Different nanomaterials can regulate autophagy through different mechanisms because of their unique physical, chemical and biological properties. In this chapter, we will introduce the effects and mechanisms of autophagy mediated by nanomaterials and the applications of autophagy induced by different nanomaterials in the field of biomedicine.

Keywords

Nanomaterials Autophagy Autophagy-modulating effect 

References

  1. Chen GY, Chen CL, Tuan HY, Yuan PX, Li KC, Yang HJ, Hu YC (2014) Graphene oxide triggers toll-like receptors/autophagy responses in vitro and inhibits tumor growth in vivo. Adv Healthc Mater 3:1486–1495CrossRefGoogle Scholar
  2. Chen GY, Meng CL, Lin KC, Tuan HY, Yang HJ, Chen CL, Li KC, Chiang CS, Hu YC (2015) Graphene oxide as a chemosensitizer: diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects. Biomaterials 40:12–22CrossRefGoogle Scholar
  3. Hulea L, Markovic Z, Topisirovic I, Simmet T, Trajkovic V (2016) Biomedical potential of mTOR modulation by nanoparticles. Trends Biotechnol 34:349–353CrossRefGoogle Scholar
  4. Ji XL, Xu B, Yao MM, Mao ZL, Zhang YQ, Xu GF, Tang QS, Wang XR, Xia YK (2016) Graphene oxide quantum dots disrupt autophagic flux by inhibiting lysosome activity in GC-2 and TM4 cell lines. Toxicology 374:10–17CrossRefGoogle Scholar
  5. Jin P, Wei P, Zhang Y, Lin J, Sha R, Hu Y, Zhang J, Zhou W, Yao H, Ren L, Yang JY, Liu Y, Wen L (2016) Autophagy-mediated clearance of ubiquitinated mutant huntingtin by graphene oxide. Nanoscale 8:18740–18750CrossRefGoogle Scholar
  6. Khan MI, Mohammad A, Patil G, Naqvi SA, Chauhan LK, Ahmad I (2012) Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles. Biomaterials 33:1477–1488CrossRefGoogle Scholar
  7. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG et al (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1–222Google Scholar
  8. Lee CM, Huang ST, Huang SH, Lin HW, Tsai HP, Wu JY, Lin CM, Chen CT (2011) C60 fullerene-pentoxifylline dyad nanoparticles enhance autophagy to avoid cytotoxic effects caused by the beta-amyloid peptide. Nanomedicine 7:107–114CrossRefGoogle Scholar
  9. Li C, Liu H, Sun Y, Wang H, Guo F, Rao S, Deng J, Zhang Y, Miao Y, Guo C, Meng J, Chen X, Li L, Li D, Xu H, Li B, Jiang C (2009) PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway. J Mol Cell Biol 1:37–45CrossRefGoogle Scholar
  10. Li X, Chen N, Su Y, He Y, Yin M, Wei M, Wang L, Huang W, Fan C, Huang Q (2014) Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells. Adv Healthc Mater 3:354–359CrossRefGoogle Scholar
  11. Lin J, Huang Z, Wu H, Zhou W, Jin P, Wei P, Zhang Y, Zheng F, Zhang J, Xu J, Hu Y, Wang Y, Li Y, Gu N, Wen L (2014) Inhibition of autophagy enhances the anticancer activity of silver nanoparticles. Autophagy 10:2006–2020CrossRefGoogle Scholar
  12. Liu HL, Zhang YL, Yang N, Zhang YX, Liu XQ, Li CG, Zhao Y, Wang YG, Zhang GG, Yang P, Guo F, Sun Y, Jiang CY (2011) A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling. Cell Death Dis 2:e159CrossRefGoogle Scholar
  13. Liu YM, Yu H, Zhang XH, Wang Y, Song ZT, Zhao J, Shi HB, Li RB, Wang YY, Zhang LW (2018) The protective role of autophagy in nephrotoxicity induced by bismuth nanoparticles through AMPK/mTOR pathway. Nanotoxicology 12:586–601CrossRefGoogle Scholar
  14. Lopes VR, Loitto V, Audinot JN, Bayat N, Gutleb AC, Cristobal S (2016) Dose-dependent autophagic effect of titanium dioxide nanoparticles in human HaCaT cells at non-cytotoxic levels. J Nanobiotechnol 14:22CrossRefGoogle Scholar
  15. Ma X, Wu Y, Jin S, Tian Y, Zhang X, Zhao Y, Yu L, Liang XJ (2011) Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment. ACS Nano 5:8629–8639CrossRefGoogle Scholar
  16. Man N, Chen Y, Zheng F, Zhou W, Wen LP (2010) Induction of genuine autophagy by cationic lipids in mammalian cells. Autophagy 6:449–454CrossRefGoogle Scholar
  17. Ren X, Chen Y, Peng H, Fang X, Zhang X, Chen Q, Wang X, Yang W, Sha X (2018) Blocking autophagic flux enhances iron oxide nanoparticle photothermal therapeutic efficiency in cancer treatment. ACS Appl Mater Interfaces 10:27701–27711CrossRefGoogle Scholar
  18. Shi S, Lin S, Li Y, Zhang T, Shao X, Tian T, Zhou T, Li Q, Lin Y (2018) Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes. Chem Commun (Camb) 54:1327–1330CrossRefGoogle Scholar
  19. Stern ST, Adiseshaiah PP, Crist RM (2012) Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity. Part Fibre Toxicol 9:20CrossRefGoogle Scholar
  20. Wang J, Li Y, Duan J, Yang M, Yu Y, Feng L, Yang X, Zhou X, Zhao Z, Sun Z (2018) Silica nanoparticles induce autophagosome accumulation via activation of the EIF2AK3 and ATF6 UPR pathways in hepatocytes. Autophagy 14:1185–1200CrossRefGoogle Scholar
  21. Wei P, Zhang L, Lu Y, Man N, Wen L (2010) C60(Nd) nanoparticles enhance chemotherapeutic susceptibility of cancer cells by modulation of autophagy. Nanotechnology 21:495101CrossRefGoogle Scholar
  22. Wei M, Fu ZF, Wang C, Zheng W, Li S, Le WD (2019) Graphene oxide nanocolloids induce autophagy-lysosome dysfunction in mouse embryonic stem cells. J Biomed Nanotechnol 15:340–351CrossRefGoogle Scholar
  23. Wen X, Wu J, Wang F, Liu B, Huang C, Wei Y (2013) Deconvoluting the role of reactive oxygen species and autophagy in human diseases. Free Radic Biol Med 65:402–410CrossRefGoogle Scholar
  24. Wu L, Zhang Y, Zhang C, Cui X, Zhai S, Liu Y, Li C, Zhu H, Qu G, Jiang G, Yan B (2014) Tuning cell autophagy by diversifying carbon nanotube surface chemistry. ACS Nano 8:2087–2099CrossRefGoogle Scholar
  25. Xu Y, Wang L, Bai R, Zhang T, Chen C (2015) Silver nanoparticles impede phorbol myristate acetate-induced monocyte-macrophage differentiation and autophagy. Nanoscale 7:16100–16109CrossRefGoogle Scholar
  26. Xue X, Wang LR, Sato Y, Jiang Y, Berg M, Yang DS, Nixon RA, Liang XJ (2014) Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer’s disease. Nano Lett 14:5110–5117CrossRefGoogle Scholar
  27. Yu L, Lu Y, Man N, Yu SH, Wen LP (2009) Rare earth oxide nanocrystals induce autophagy in HeLa cells. Small 5:2784–2787CrossRefGoogle Scholar
  28. Zabirnyk O, Yezhelyev M, Seleverstov O (2007) Nanoparticles as a novel class of autophagy activators. Autophagy 3:278–281CrossRefGoogle Scholar
  29. Zhang Q, Yang W, Man N, Zheng F, Shen Y, Sun K, Li Y, Wen LP (2009) Autophagy-mediated chemosensitization in cancer cells by fullerene C60 nanocrystal. Autophagy 5:1107–1117CrossRefGoogle Scholar
  30. Zhang Y, Yu C, Huang G, Wang C, Wen L (2010) Nano rare-earth oxides induced size-dependent vacuolization: an independent pathway from autophagy. Int J Nanomedicine 5:601–609CrossRefGoogle Scholar
  31. Zhang X, Dong Y, Zeng X, Liang X, Li X, Tao W, Chen H, Jiang Y, Mei L, Feng SS (2014) The effect of autophagy inhibitors on drug delivery using biodegradable polymer nanoparticles in cancer treatment. Biomaterials 35:1932–1943CrossRefGoogle Scholar
  32. Zhang J, Zou Z, Wang B, Xu G, Wu Q, Zhang YC, Yuan ZY, Yang X, Yu C (2018) Lysosomal deposition of copper oxide nanoparticles triggers HUVEC cells death. Biomaterials 161:228–239CrossRefGoogle Scholar
  33. Zheng W, Wei M, Li S, Le W (2016) Nanomaterial-modulated autophagy: underlying mechanisms and functional consequences. Nanomedicine (Lond) 11:1417–1430CrossRefGoogle Scholar

Copyright information

© Science Press and Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Liaoning Provincial Center for Clinical Research on Neurological DiseasesThe First Affiliated Hospital, Dalian Medical UniversityDalianPeople’s Republic of China

Personalised recommendations