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Zinc Transporters and Zinc Signaling in Skin Formation and Diseases

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Zinc Signaling

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Abstract

The skin is the first body region to manifest zinc deficiency. Recent studies have revealed that the zinc transporters, especially zinc importers belonging to the Zrt-Irt-like (ZIP) family, play crucial roles in skin homeostasis. Fourteen ZIP members have been identified in humans, with at least 6 members being related to skin development and maintenance. ZIP1, ZIP2, ZIP4, and ZIP10 are associated with epidermal morphogenesis and disorders, whereas ZIP7 and ZIP13 are essential for dermis formation and collagen metabolism. Mouse models in combination with clinical data have shown the molecular pathogenic mechanisms involving ZIP members. Although other family members have not been well studied with respect to their role in the skin, their direct or indirect associations are also considerable and they are believed to be drug targets for skin diseases. Therefore, precise analysis and understanding of ZIP family members are indispensable for the care and treatment of skin disorders.

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Author information

Authors and Affiliations

  1. Applied Biotechnology, Ajou University, Suwon, South Korea

    Bum-Ho Bin

  2. Bio-Center, Gyeonggido Business and Science Accelerator, Suwon, South Korea

    Mi-Gi Lee

  3. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Takafumi Hara & Teruhisa Takagishi

  4. Molecular and Cellular Physiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Toshiyuki Fukada

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  1. Bum-Ho Bin
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  2. Mi-Gi Lee
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  3. Takafumi Hara
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  4. Teruhisa Takagishi
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  5. Toshiyuki Fukada
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Correspondence to Toshiyuki Fukada .

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Editors and Affiliations

  1. Molecular and Cellular Physiology Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Toshiyuki Fukada

  2. Division of Integrated Life Science Graduate School of Biostudies, Kyoto University, Kyoto, Japan

    Taiho Kambe

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Bin, BH., Lee, MG., Hara, T., Takagishi, T., Fukada, T. (2019). Zinc Transporters and Zinc Signaling in Skin Formation and Diseases. In: Fukada, T., Kambe, T. (eds) Zinc Signaling. Springer, Singapore. https://doi.org/10.1007/978-981-15-0557-7_15

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