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Cerium Oxide-Based Nanozymes in Biology and Medicine

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Advances in Spectroscopy: Molecules to Materials

Part of the book series: Springer Proceedings in Physics ((SPPHY,volume 236))

Abstract

Biological enzymes are excellent biocatalysts because they display high specificity to their substrates and accelerate the rate of biochemical reactions to many folds. Despite these and several other advantages, the catalytic performances of natural enzymes are found to be compromised when exposed to heavy metals-based inhibitors and different conditions of their optimum temperature and pH. The high cost of synthesis, isolation, and purification are some of the typical constraints over their broad-spectrum utility. However, nanoparticle-based biological enzyme mimetic is currently growing exponentially with particular interest to the biological applications. Although there are several types of nanomaterials discovered for displaying various biological enzyme-like activities, this chapter comprehensively covers the cerium oxide nanoparticles (nanoceria)-based enzyme mimetic systems and related biological applications. Recently, nanoceria has been explored for possessing the superoxide dismutase, catalase, peroxidase, and oxidase enzyme-like activities. Nanoceria has reported to exhibit antioxidant (ability to inhibit oxidative stress) as well as prooxidant (ability to generate reactive oxygen species) activities. These enzyme mimetic activities can be tuned by modulating the synthesis process and surface modification of nanoceria.

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Acknowledgements

The financial assistance for the Centre for Nanotechnology Research and Applications (CENTRA) by The Gujarat Institute for Chemical Technology (GICT) is thankfully acknowledged. S. Singh would like to acknowledge the financial support from Ahmedabad University as Seed Grant (AU/SG/SAS/DBLS/17-18/03) and the Department of Science and Technology, Science and Engineering Research Board (SERB) (Grant No.: ILS/SERB/2015-16/01) to Sanjay Singh under the scheme of Start-Up Research Grant (Young Scientists) in Life Sciences. N.Yadav thank Council of Scientific and Industrial Research (CSIR) for providing Junior Research Fellowship.

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Authors and Affiliations

  1. Division of Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Central Campus, Navrangpura, Ahmedabad, 380009, Gujarat, India

    Nisha Yadav, Vaishwik Patel & Sanjay Singh

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  1. Nisha Yadav
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  2. Vaishwik Patel
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  3. Sanjay Singh
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Correspondence to Sanjay Singh .

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Editors and Affiliations

  1. Department of Physics, Institute of Infrastructure Technology Research And Management, Ahmedabad, Gujarat, India

    Dheeraj Kumar Singh

  2. Department of Chemistry, Institute of Infrastructure Technology Research And Management, Ahmedabad, Gujarat, India

    Sourav Das

  3. Department of Physics and Earth Science, Jacobs University Bremen gGmbH, Bremen, Germany

    Arnulf Materny

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Yadav, N., Patel, V., Singh, S. (2019). Cerium Oxide-Based Nanozymes in Biology and Medicine. In: Singh, D., Das, S., Materny, A. (eds) Advances in Spectroscopy: Molecules to Materials. Springer Proceedings in Physics, vol 236. Springer, Singapore. https://doi.org/10.1007/978-981-15-0202-6_15

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  • DOI: https://doi.org/10.1007/978-981-15-0202-6_15

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