Stem Cell Therapy

  • Shinya Minatoguchi


Bone marrow-derived mononuclear cells (BM-MNCs) and mesenchymal stem cells (MSCs) have been considered candidate cell sources for stem cell therapy against AMI because animal studies using these cells showed beneficial effects. However, clinical trials using BM-MNCs and MSCs demonstrated their safety but their beneficial effects were small in patients with AMI. Therefore, a new cell source is required for stem cell therapy. Muse cells showed greater effects to reduce the myocardial infarct size and improve the cardiac function than MSCs. Muse cells showed differentiation into cardiomyocytes and vessels as well as paracrine effects. Muse cell therapy may be a promising and epoch-making stem cell therapy for the treatment of AMI. Clinical trials are warranted.


Muse cells Mesenchymal stem cells Cardiomyocyte regeneration Infarct size Cardiac function 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Shinya Minatoguchi
    • 1
  1. 1.Head of Heart Failure Center, Gifu Municipal HospitalEmeritus Professor, Gifu University Graduate School of MedicineGifuJapan

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