Critical Appraisal of a Clinical Trial

  • Bhanu Prasad Venkatesulu


Critical appraisal of a clinical trial involves systematic examination of research to assess its reliability, value, and relevance in clinical decision making. Critical appraisal of the trial is a very important component in evidence-based practice. Each trial has to be scrutinized in various aspects like study design, arms, comparator arm, trial run and recruitment, outcomes, toxicity, potential confounders and bias, statistical methods, and ethical issues. The chapter summarizes on how to perform a critical appraisal of a clinical trial.


Clinical trials Appraisal Bias 


  1. 1.
    Al-Jundi A, Sakka S. Critical appraisal of clinical research. J Clin Diagn Res. 2017;11(5):JE01–5.PubMedPubMedCentralGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Bhanu Prasad Venkatesulu
    • 1
  1. 1.MD Anderson Cancer CenterHoustonUSA

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