Therapeutic Index and Its Clinical Significance

  • Rony Benson
  • Supriya Mallick


The main purpose of delivering curative radiotherapy is maximizing cure with minimal normal tissue complications. The therapeutic index is a correlation of tumor control probability and normal tissue complication probability at different doses of radiation. Usually tumors with a wide therapeutic index are easily curable by radiotherapy. This chapter aims at understanding the definition of therapeutic index and its clinical implications.


Therapeutic index Tumor control probability Normal tissue complication probability 


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    Chargari C, Magne N, Guy JB, Rancoule C, Levy A, Goodman KA, et al. Optimize and refine therapeutic index in radiation therapy: overview of a century. Cancer Treat Rev. 2016;45:58–67.CrossRefGoogle Scholar
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    Beasley M, Driver D, Dobbs HJ. Complications of radiotherapy: improving the therapeutic index. Cancer Imaging. 2005;5:78–84.CrossRefGoogle Scholar
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    Montay-Gruel P, Meziani L, Yakkala C, Vozenin MC. Expanding the therapeutic index of radiation therapy by normal tissue protection. Br J Radiol. 2018:20180008.

Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Rony Benson
    • 1
  • Supriya Mallick
    • 2
  1. 1.Department of Medical OncologyRCCThiruvananthapuramIndia
  2. 2.Department of Radiation OncologyNational Cancer Institute-India (NCI-India)JhajjarIndia

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