Therapeutic Index and Its Clinical Significance
The main purpose of delivering curative radiotherapy is maximizing cure with minimal normal tissue complications. The therapeutic index is a correlation of tumor control probability and normal tissue complication probability at different doses of radiation. Usually tumors with a wide therapeutic index are easily curable by radiotherapy. This chapter aims at understanding the definition of therapeutic index and its clinical implications.
KeywordsTherapeutic index Tumor control probability Normal tissue complication probability
- 3.Montay-Gruel P, Meziani L, Yakkala C, Vozenin MC. Expanding the therapeutic index of radiation therapy by normal tissue protection. Br J Radiol. 2018:20180008. https://doi.org/10.1259/bjr.20180008.