Nanoparticles as New Emerging Antibacterials: Potentials and Limitations

  • Fohad Mabood HusainEmail author
  • Mohammad Shavez Khan
  • Saba Siddiqui
  • Altaf Khan
  • Mohammed Arshad
  • Abdullah A. Alyousef
  • Mashihur Rahman
  • Nasser A. Al-Shabib
  • Iqbal Ahmad


The use and abuse of antimicrobials have led to the emergence of multi-drug resistant (MDR) bacteria and the spread of resistant organisms and is one of the major global threats for healthcare professionals. Alternatives to conventional antibiotics for combating resistant infections are the need of the hour. Nanotechnology-based drugs offer a ray of hope in the fight against MDR bacteria for patients as well as clinicians. Diverse types of nanomaterials have been synthesized from metallic particles with promising antibacterial activity. Efficacy of these nanomaterials depends on their interactions with bacterial cells and their mechanisms of action differ based on their physico-chemical properties. Development of novel and potent nanoantimicrobials requires in-depth knowledge of the physico-chemical properties of nanoparticles and the biological characteristics of bacteria. However, there is still a long way to go as there are major issues related to the toxicity and stability of nanoparticles. Moreover, the economic feasibility of transferring the technology from bench to bedside needs to be addressed. The present review highlights the antibacterial effects of nanoparticles, their mechanisms of action, factors affecting the activity of NPs and challenges of ongoing and future research.


Nanoparticle Drug resistance MDR Biofilm 



The authors are grateful to the King Saud University and Aligarh Muslim University for providing research facilities.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Fohad Mabood Husain
    • 1
    Email author
  • Mohammad Shavez Khan
    • 2
  • Saba Siddiqui
    • 3
  • Altaf Khan
    • 4
  • Mohammed Arshad
    • 5
  • Abdullah A. Alyousef
    • 5
  • Mashihur Rahman
    • 6
  • Nasser A. Al-Shabib
    • 1
  • Iqbal Ahmad
    • 2
  1. 1.Department of Food Science and NutritionCollege of Food and Agriculture, King Saud UniversityRiyadhKingdom of Saudi Arabia
  2. 2.Department of Agricultural Microbiology, Faculty of Agricultural SciencesAligarh Muslim UniversityAligarhIndia
  3. 3.College of Agricultural SciencesIntegral UniversityLucknowIndia
  4. 4.Microbiology Unit, Central Research LaboratoryCollege of Pharmacy, King Saud UniversityRiyadhKingdom of Saudi Arabia
  5. 5.Department of Clinical Laboratory ScienceCollege of Applied Medical Sciences, King Saud UniversityRiyadhKingdom of Saudi Arabia
  6. 6.School of Life SciencesB.S. Abdur Rahman UniversityChennaiIndia

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