Medicinal Plants as a Reservoir of New Structures for Anti-infective Compounds
The continued emergence of antimicrobial resistance across a spectrum of infectious pathogens presents a clear and urgent threat to human health across the globe. This trend has been further complicated by a decline in the discovery of novel chemical classes for anti-infective development. Natural products – primarily microbial in origin – have historically served as a key resource for anti-infective drug discovery efforts. On the other hand, natural products from the plant kingdom have served as a source of traditional medicine for millennia, and yet they remain relatively unexplored. The aim of this chapter is to provide an overview of plant natural products and discuss their potential as a resource for ongoing and future drug discovery efforts to fill the anti-infective pipeline and combat antimicrobial-resistant infections.
KeywordsAntibiotic resistance Pharmacognosy Medicinal plants Ethnobotany Phytochemistry Secondary metabolites
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