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Bio Mimicking of Extracellular Matrix

  • Moumita Ghosh
  • Michal Halperin-Sternfeld
  • Lihi Adler-AbramovichEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1174)

Abstract

Biomaterials play a critical role in regenerative strategies such as stem cell-based therapies and tissue engineering, aiming to replace, remodel, regenerate, or support damaged tissues and organs. The design of appropriate three-dimensional (3D) scaffolds is crucial for generating bio-inspired replacement tissues. These scaffolds are primarily composed of degradable or non-degradable biomaterials and can be employed as cells, growth factors, or drug carriers. Naturally derived and synthetic biomaterials have been widely used for these purposes, but the ideal biomaterial remains to be found. Researchers from diversified fields have attempted to design and fabricate novel biomaterials, aiming to find novel theranostic approaches for tissue engineering and regenerative medicine. Since no single biomaterial has been found to possess all the necessary characteristics for an ideal performance, over the years scientists have tried to develop composite biomaterials that complement and combine the beneficial properties of multiple materials into a superior matrix. Herein, we highlight the structural features and performance of various biomaterials and their application in regenerative medicine and for enhanced tissue engineering approaches.

Keywords

Biomaterials Extracellular matrix Scaffolds Peptides Hydrogels Supramolecular polymers 

Abbreviations

3D

Three-dimensional

Al

Alumina

bFGF

Basic fibroblast growth factor

BMP-2

Bone morphogenic protein 2

CaP

Calcium phosphate

DOPA

3,4-dihydroxy-L-phenylalanine

ECM

Extracellular matrix

Fmoc

Fluorenylmethyloxycarbonyl

FmocFF

Fluorenylmethoxycarbonyl-diphenylalanine

GAGs

Glycosaminoglycans

GDNF

Glial cell derived neurotrophic factor

Mg

Magnesium

Mn

Manganese

MSCs

Mesenchymal stem cells

Na

Sodium

PCL

Poly(e-caprolactone)

PEG

Polyethylene glycol

PET

Polyethylene terephthalate

PGA

Polyglycolic acid

PGs

Proteoglycans

PLA

Polylactic acid

PLGA

Polylactic-co-glycolide

PMMA

Poly(methylmethacrylate)

PTFE

Poly(tetrafluoroethylene)

PU

Polyurethanes

RP

Rapid prototyping

Si

Silicon

TCP

Tricalcium phosphate

Ti

Titanium

UV

Ultraviolet

VEGF

Vascular endothelial growth factor

Zn

Zinc

Zr

Zirconium

Notes

Acknowledgments

We thank the support of the ISRAEL SCIENCE FOUNDATION (grant No. 1732/17) (L.A.A.). We thank Sharon Tsach for graphical assistance and the members of the Adler-Abramovich group for helpful discussions.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Moumita Ghosh
    • 1
  • Michal Halperin-Sternfeld
    • 1
  • Lihi Adler-Abramovich
    • 1
    Email author
  1. 1.Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

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