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Carbon Nanostructure-Based Materials: A Novel Tool for Detection of Alzheimer’s Disease

  • Mohammad AshfaqEmail author
  • Neetu Talreja
  • Divya Chuahan
  • Werayut Srituravanich
Chapter

Abstract

Alzheimer’s disease is one of the most common forms of dementia and is an overwhelming neurodegenerative disease. Usually, this neurological condition is categorized by a loss of cognitive functions and recognized pathophysiological hallmarks in the brain such as accumulation of extracellular (amyloid-β (Aβ) peptide) and intracellular (neurofibrillar tangles of hyperphosphorylated τ protein) protein. Presently, a huge number (approximately 35 million) of people are affected by this form of dementia and neurodegenerative disease. The situation becomes more dangerous and will lead to social burden in the near future. Therefore, there is a need to develop effective therapy and early diagnostic approaches. In this context, biosensor has become an indispensable tool in biomarker sensing, in which sensor electrode materials play critical roles in accurate and selective sensing. Carbon nanostructure-based materials have the potential ability for biosensor platform because of their excellent mechanical, electronic, optical, and easy functionalization ability. Herein, we discuss the various carbon nanostructure-based materials, biomarkers of Alzheimer’s disease, carbon nanostructured material-based biosensor, and future prospects in the detection of Alzheimer’s disease.

Keywords

Alzheimer’s disease Nanomaterials Biosensor Biomarkers Neurological disease 

Notes

Acknowledgment

The authors acknowledge support from Chulalongkorn University through Chulalongkorn Academic Advancement into its Second Century Project (Small Medical Device) and support from NPDF, SERB, Department of Science and Technology, New Delhi, India, in the form of a research grant (PDF/2016/003602).

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Mohammad Ashfaq
    • 1
    • 2
    • 3
    Email author
  • Neetu Talreja
    • 4
  • Divya Chuahan
    • 5
  • Werayut Srituravanich
    • 2
    • 3
  1. 1.School of Life ScienceBS Abdur Rahaman Crescent Institute of Science and TechnologyChennaiIndia
  2. 2.Department of Mechanical Engineering, Faculty of EngineeringChulalongkorn UniversityBangkokThailand
  3. 3.Biomedical Engineering Research Center, Faculty of EngineeringChulalongkorn UniversityBangkokThailand
  4. 4.Department of Bio-nanotechnologyGachon UniversitySeongnamSouth Korea
  5. 5.Department of ChemistryPunjab UniversityChandigarhIndia

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