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Seroprevalence and Risk Factors of Severe Fever with Thrombocytopenia Syndrome

Seroepidemiology of SFTS
  • Shuetsu FukushiEmail author
Chapter

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV). This phlebovirus was first reported to cause this disease in 2011 in China. Since its identification, serological surveys of the healthy human population and domesticated and wild animals in China, Japan, and South Korea have been conducted. This literature review shows that the SFTSV seroprevalence in healthy people ranges from 0% to 10.5% and depends on age, occupation, living area, and tick-bite history. High rates of antibody positivity have been detected in many domesticated and wild animals. Thus, these animals may act as amplifying hosts of the virus. The implications and challenges facing the seroepidemiology of this novel bunyavirus are discussed.

Keywords

SFTS Seroepidemiology ELISA IFA Neutralization test 

Notes

Acknowledgments

I thank Drs. Masayuki Saijo, Masayuki Shimojima, Takeshi Kurosu, Tomoki Yoshikawa, Shumpei Watanabe, Hideki Tani, and Aiko Fukuma (Department of Virology 1, NIID) for helpful discussions.

References

  1. Bosco-Lauth AM, Panella NA, Root JJ, Gidlewski T, Lash RR, Harmon JR, Burkhalter KL, Godsey MS, Savage HM, Nicholson WL, Komar N, Brault AC (2015) Serological investigation of heartland virus (Bunyaviridae: Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012–2013. Am J Trop Med Hyg 92(6):1163–1167.  https://doi.org/10.4269/ajtmh.14-0702 CrossRefPubMedPubMedCentralGoogle Scholar
  2. Cui F, Cao HX, Wang L, Zhang SF, Ding SJ, Yu XJ, Yu H (2013) Clinical and epidemiological study on severe fever with thrombocytopenia syndrome in Yiyuan County, Shandong Province, China. Am J Trop Med Hyg 88(3):510–512.  https://doi.org/10.4269/ajtmh.11-0760 CrossRefPubMedPubMedCentralGoogle Scholar
  3. Gokuden M, Fukushi S, Saijo M, Nakadouzono F, Iwamoto Y, Yamamoto M, Hozumi N, Nakayama K, Ishitani K, Nishi N, Ootsubo M (2018) Low Seroprevalence of severe fever with thrombocytopenia syndrome virus antibodies in individuals living in an endemic area in Japan. Jpn J Infect Dis 71(3):225–228.  https://doi.org/10.7883/yoken.JJID.2017.497 CrossRefGoogle Scholar
  4. Hayasaka D, Fuxun Y, Yoshikawa A, Posadas-Herrera G, Shimada S, Tun MM, Agoh M, Morita K (2016) Seroepidemiological evidence of severe fever with thrombocytopenia syndrome virus infections in wild boars in Nagasaki, Japan. Trop Med Health 44:6.  https://doi.org/10.1186/s41182-016-0009-6 CrossRefPubMedPubMedCentralGoogle Scholar
  5. Hu C, Guo C, Yang Z, Wang L, Hu J, Qin S, Cui N, Peng W, Liu K, Liu W, Cao W (2015) The severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) antibody in a highly endemic region from 2011 to 2013: a comparative serological study. Am J Trop Med Hyg 92(3):479–481.  https://doi.org/10.4269/ajtmh.14-0447 CrossRefPubMedPubMedCentralGoogle Scholar
  6. Huang X, Zhang Z, Jin G, Wang X, Tan C, Yin H, Wang S (2017) Presence of antibodies against severe fever with thrombocytopenia syndrome virus in non-endemic areas of China. Jpn J Infect Dis 70(3):248–251.  https://doi.org/10.7883/yoken.JJID.2016.214 CrossRefPubMedGoogle Scholar
  7. ICTV (2016) Virus taxonomy: 2016 releaseGoogle Scholar
  8. Jiao Y, Zeng X, Guo X, Qi X, Zhang X, Shi Z, Zhou M, Bao C, Zhang W, Xu Y, Wang H (2012) Preparation and evaluation of recombinant severe fever with thrombocytopenia syndrome virus nucleocapsid protein for detection of total antibodies in human and animal sera by double-antigen sandwich enzyme-linked immunosorbent assay. J Clin Microbiol 50(2):372–377.  https://doi.org/10.1128/JCM.01319-11 CrossRefPubMedPubMedCentralGoogle Scholar
  9. Kim KH, Yi J, Kim G, Choi SJ, Jun KI, Kim NH, Choe PG, Kim NJ, Lee JK, Oh MD (2013) Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis 19(11):1892–1894.  https://doi.org/10.3201/eid1911.130792 CrossRefPubMedPubMedCentralGoogle Scholar
  10. Kim KH, Ko MK, Kim N, Kim HH, Yi J (2017) Seroprevalence of severe fever with thrombocytopenia syndrome in Southeastern Korea, 2015. J Korean Med Sci 32(1):29–32.  https://doi.org/10.3346/jkms.2017.32.1.29 CrossRefPubMedGoogle Scholar
  11. Li Z, Hu J, Bao C, Li P, Qi X, Qin Y, Wang S, Tan Z, Zhu Y, Tang F, Zhou M (2014) Seroprevalence of antibodies against SFTS virus infection in farmers and animals, Jiangsu, China. J Clin Virol 60(3):185–189.  https://doi.org/10.1016/j.jcv.2014.03.020 CrossRefPubMedGoogle Scholar
  12. Li Z, Bao C, Hu J, Liu W, Wang X, Zhang L, Ji Z, Feng Z, Li L, Shen A, Liu X, Zhao H, Tan W, Zhou J, Qi X, Zhu Y, Tang F, Cardona CJ, Xing Z (2016) Ecology of the tick-borne Phlebovirus causing severe fever with thrombocytopenia syndrome in an endemic area of China. PLoS Negl Trop Dis 10(4):e0004574.  https://doi.org/10.1371/journal.pntd.0004574 CrossRefPubMedPubMedCentralGoogle Scholar
  13. Liang S, Bao C, Zhou M, Hu J, Tang F, Guo X, Jiao Y, Zhang W, Luo P, Li L, Zhu K, Tan W, Lu Q, Ge H, Chen A (2014) Seroprevalence and risk factors for severe fever with thrombocytopenia syndrome virus infection in Jiangsu Province, China, 2011. Am J Trop Med Hyg 90(2):256–259.  https://doi.org/10.4269/ajtmh.13-0423 CrossRefPubMedPubMedCentralGoogle Scholar
  14. Liu JW, Wen HL, Fang LZ, Zhang ZT, He ST, Xue ZF, Ma DQ, Zhang XS, Wang T, Yu H, Zhang Y, Zhao L, Yu XJ (2014) Prevalence of SFTSV among Asian house shrews and rodents, China, January–August 2013. Emerg Infect Dis 20(12):2126–2128.  https://doi.org/10.3201/eid2012.141013 CrossRefPubMedPubMedCentralGoogle Scholar
  15. Lyu Y, Ding F, Sun J, Xu PP, Hu JY, Xie SY, Li KC, Chang HW, Qin W, Yu L, Xie H, Li GJ, Yang CW, Huang XX, Wang Q, Zhang XJ (2016) Seroprevalence and risk factors of severe fever with thrombocytopenia syndrome virus infection in endemic areas. Infect Dis (Lond) 48(7):544–549.  https://doi.org/10.3109/23744235.2016.1165351 CrossRefGoogle Scholar
  16. Matsuno K, Weisend C, Travassos da Rosa AP, Anzick SL, Dahlstrom E, Porcella SF, Dorward DW, Yu XJ, Tesh RB, Ebihara H (2013) Characterization of the Bhanja serogroup viruses (Bunyaviridae): a novel species of the genus Phlebovirus and its relationship with other emerging tick-borne phleboviruses. J Virol 87(7):3719–3728.  https://doi.org/10.1128/JVI.02845-12 CrossRefPubMedPubMedCentralGoogle Scholar
  17. McMullan LK, Folk SM, Kelly AJ, MacNeil A, Goldsmith CS, Metcalfe MG, Batten BC, Albarino CG, Zaki SR, Rollin PE, Nicholson WL, Nichol ST (2012) A new phlebovirus associated with severe febrile illness in Missouri. N Engl J Med 367(9):834–841.  https://doi.org/10.1056/NEJMoa1203378 CrossRefPubMedGoogle Scholar
  18. Meyer B, Drosten C, Muller MA (2014) Serological assays for emerging coronaviruses: challenges and pitfalls. Virus Res 194:175–183.  https://doi.org/10.1016/j.virusres.2014.03.018 CrossRefPubMedGoogle Scholar
  19. National Institute of Infectious Diseases. IASR (2016) 37(3) (No.433)Google Scholar
  20. Ni H, Yang F, Li Y, Liu W, Jiao S, Li Z, Yi B, Chen Y, Hou X, Hu F, Ding Y, Bian G, Du Y, Xu G, Cao G (2015) Apodemus agrarius is a potential natural host of severe fever with thrombocytopenia syndrome (SFTS)-causing novel bunyavirus. J Clin Virol 71:82–88.  https://doi.org/10.1016/j.jcv.2015.08.006 CrossRefPubMedGoogle Scholar
  21. Niu G, Li J, Liang M, Jiang X, Jiang M, Yin H, Wang Z, Li C, Zhang Q, Jin C, Wang X, Ding S, Xing Z, Wang S, Bi Z, Li D (2013) Severe fever with thrombocytopenia syndrome virus among domesticated animals, China. Emerg Infect Dis 19(5):756–763.  https://doi.org/10.3201/eid1905.120245 CrossRefPubMedPubMedCentralGoogle Scholar
  22. ProMED (2017) Archive Number: 20171012.5376692Google Scholar
  23. Rocha ES, Oliveira JG, Santos JR, Rodrigues GO, Figueiredo LB, Pessanha JE, Proietti FA, Fonseca FG, Bonjardim CA, Ferreira PC, Kroon EG (2013) Recombinant envelope protein-based enzyme immunoassay for IgG antibodies is comparable to neutralization tests for epidemiological studies of dengue infection. J Virol Methods 187(1):114–120.  https://doi.org/10.1016/j.jviromet.2012.09.012 CrossRefPubMedGoogle Scholar
  24. Schwarz NG, Mertens E, Winter D, Maiga-Ascofare O, Dekker D, Jansen S, Tappe D, Randriamampionona N, May J, Rakotozandrindrainy R, Schmidt-Chanasit J (2017) No serological evidence for Zika virus infection and low specificity for anti-Zika virus ELISA in malaria positive individuals among pregnant women from Madagascar in 2010. PLoS One 12(5):e0176708.  https://doi.org/10.1371/journal.pone.0176708 CrossRefPubMedPubMedCentralGoogle Scholar
  25. Sun JM, Zhang YJ, Gong ZY, Zhang L, Lv HK, Lin JF, Chai CL, Ling F, Liu SL, Gu SP, Zhu ZH, Zheng XH, Lan YQ, Ding F, Huang WZ, Xu JR, Chen EF, Jiang JM (2015) Seroprevalence of severe fever with thrombocytopenia syndrome virus in southeastern China and analysis of risk factors. Epidemiol Infect 143(4):851–856.  https://doi.org/10.1017/S0950268814001319 CrossRefPubMedGoogle Scholar
  26. Sun J, Lu L, Wu H, Yang J, Ren J, Liu Q (2017) The changing epidemiological characteristics of severe fever with thrombocytopenia syndrome in China, 2011–2016. Sci Rep 7(1):9236.  https://doi.org/10.1038/s41598-017-08042-6 CrossRefPubMedPubMedCentralGoogle Scholar
  27. Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, Kamei T, Honda M, Ninomiya D, Sakai T, Senba T, Kaneyuki S, Sakaguchi S, Satoh A, Hosokawa T, Kawabe Y, Kurihara S, Izumikawa K, Kohno S, Azuma T, Suemori K, Yasukawa M, Mizutani T, Omatsu T, Katayama Y, Miyahara M, Ijuin M, Doi K, Okuda M, Umeki K, Saito T, Fukushima K, Nakajima K, Yoshikawa T, Tani H, Fukushi S, Fukuma A, Ogata M, Shimojima M, Nakajima N, Nagata N, Katano H, Fukumoto H, Sato Y, Hasegawa H, Yamagishi T, Oishi K, Kurane I, Morikawa S, Saijo M (2014) The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 209(6):816–827.  https://doi.org/10.1093/infdis/jit603 CrossRefGoogle Scholar
  28. Taniguchi S, Fukuma A, Tani H, Fukushi S, Saijo M, Shimojima M (2017) A neutralization assay with a severe fever with thrombocytopenia syndrome virus strain that makes plaques in inoculated cells. J Virol Methods 244:4–10.  https://doi.org/10.1016/j.jviromet.2017.01.005 CrossRefPubMedGoogle Scholar
  29. Wang GS, Wang JB, Tian FL, Zhang HJ, Yin FF, Xu C, Xu D, Huang YT, Yu XJ (2017) Severe fever with thrombocytopenia syndrome virus infection in minks in China. Vector Borne Zoonotic Dis 17(8):596–598.  https://doi.org/10.1089/vbz.2017.2115 CrossRefPubMedGoogle Scholar
  30. Wei J, Li S, Dong JH, Tian H, Chowell G, Tian HY, Lv W, Han ZQ, Xu B, Yu PB, Wang JJ (2015) The first human infection with severe fever with thrombocytopenia syndrome virus in Shaanxi Province, China. Int J Infect Dis 35:37–39.  https://doi.org/10.1016/j.ijid.2015.02.014 CrossRefPubMedGoogle Scholar
  31. Xing Z, Schefers J, Schwabenlander M, Jiao Y, Liang M, Qi X, Li C, Goyal S, Cardona CJ, Wu X, Zhang Z, Li D, Collins J, Murtaugh MP (2013) Novel bunyavirus in domestic and captive farmed animals, Minnesota, USA. Emerg Infect Dis 19(9):1487–1489.  https://doi.org/10.3201/eid1909.130165 CrossRefPubMedPubMedCentralGoogle Scholar
  32. Xing X, Guan X, Liu L, Zhan J, Jiang H, Liu L, Li G, Xiong J, Tan L, Xu J, Jiang Y, Yao X, Zhan F, Nie S (2016) Natural transmission model for severe fever with thrombocytopenia syndrome Bunyavirus in villages of Hubei Province, China. Medicine (Baltimore) 95(4):e2533.  https://doi.org/10.1097/MD.0000000000002533 CrossRefGoogle Scholar
  33. Yoshikawa T, Fukushi S, Tani H, Fukuma A, Taniguchi S, Toda S, Shimazu Y, Yano K, Morimitsu T, Ando K, Yoshikawa A, Kan M, Kato N, Motoya T, Kuzuguchi T, Nishino Y, Osako H, Yumisashi T, Kida K, Suzuki F, Takimoto H, Kitamoto H, Maeda K, Takahashi T, Yamagishi T, Oishi K, Morikawa S, Saijo M, Shimojima M (2014) Sensitive and specific PCR systems for detection of both Chinese and Japanese severe fever with thrombocytopenia syndrome virus strains and prediction of patient survival based on viral load. J Clin Microbiol 52(9):3325–3333.  https://doi.org/10.1128/JCM.00742-14 CrossRefPubMedPubMedCentralGoogle Scholar
  34. Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang L, Zhang QF, Popov VL, Li C, Qu J, Li Q, Zhang YP, Hai R, Wu W, Wang Q, Zhan FX, Wang XJ, Kan B, Wang SW, Wan KL, Jing HQ, Lu JX, Yin WW, Zhou H, Guan XH, Liu JF, Bi ZQ, Liu GH, Ren J, Wang H, Zhao Z, Song JD, He JR, Wan T, Zhang JS, Fu XP, Sun LN, Dong XP, Feng ZJ, Yang WZ, Hong T, Zhang Y, Walker DH, Wang Y, Li DX (2011) Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364(16):1523–1532.  https://doi.org/10.1056/NEJMoa1010095 CrossRefPubMedPubMedCentralGoogle Scholar
  35. Zeng P, Ma L, Gao Z, Wang J, Liu J, Huang X, Yang Q, Cao R, Wen X, Zhu L, Ma H, Yang Z, Lee TH, Brambilla D, Yuan M, Glynn S, Ness P, Kleinman S, Busch M, Shan H, International Component of the NRE, Donor Evaluation S, III (2015) A study of seroprevalence and rates of asymptomatic viremia of severe fever with thrombocytopenia syndrome virus among Chinese blood donors. Transfusion 55(5):965–971.  https://doi.org/10.1111/trf.12953 CrossRefPubMedGoogle Scholar
  36. Zhan J, Wang Q, Cheng J, Hu B, Li J, Zhan F, Song Y, Guo D (2017) Current status of severe fever with thrombocytopenia syndrome in China. Virol Sin 32(1):51–62.  https://doi.org/10.1007/s12250-016-3931-1 CrossRefPubMedPubMedCentralGoogle Scholar
  37. Zhang YZ, Zhou DJ, Qin XC, Tian JH, Xiong Y, Wang JB, Chen XP, Gao DY, He YW, Jin D, Sun Q, Guo WP, Wang W, Yu B, Li J, Dai YA, Li W, Peng JS, Zhang GB, Zhang S, Chen XM, Wang Y, Li MH, Lu X, Ye C, de Jong MD, Xu J (2012) The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China. J Virol 86(5):2864–2868.  https://doi.org/10.1128/JVI.06192-11 CrossRefPubMedPubMedCentralGoogle Scholar
  38. Zhang L, Ye L, Ojcius DM, Lou X, Wang C, feng C, Sun Y, Wang Z, Li S, Zhang Y (2014a) Characterization of severe fever with thrombocytopenia syndrome in rural regions of Zhejiang, China. PLoS One 9(10):e111127.  https://doi.org/10.1371/journal.pone.0111127 CrossRefPubMedPubMedCentralGoogle Scholar
  39. Zhang L, Sun J, Yan J, Lv H, Chai C, Sun Y, Shao B, Jiang J, Chen Z, Kortekaas J, Zhang Y (2014b) Antibodies against severe fever with thrombocytopenia syndrome virus in healthy people, China, 2013. Emerg Infect Dis 20(8):1355–1357.  https://doi.org/10.3201/eid2008.131796 CrossRefPubMedPubMedCentralGoogle Scholar
  40. Zhao L, Zhai S, Wen H, Cui F, Chi Y, Wang L, Xue F, Wang Q, Wang Z, Zhang S, Song Y, Du J, Yu XJ (2012) Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis 18(6):963–965.  https://doi.org/10.3201/eid1806.111345 CrossRefPubMedPubMedCentralGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Virology INational Institute of Infectious DiseasesTokyoJapan

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