Cancer: Genetics and Important Pathways

  • Madhumita Roy
  • Amitava Datta


We have seen in Chap.  1 that all the hallmarks of cancer are related to molecular mechanisms in cells, driven by expression levels of key genes. Moreover, these genes are many times connected through genetic pathways. We have discussed the apoptosis pathway in Chap.  1. We start this chapter with a review of the fundamental concepts in genetics and molecular biology. We then discuss the genetic landscape of cancer. It is a complex problem to implicate specific genes for particular types of cancer, and our understanding is evolving all the time. We discuss the current understanding of the genetic landscapes for several important types of cancer. Finally we discuss some of the important pathways involved in cancer.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Madhumita Roy
    • 1
  • Amitava Datta
    • 2
  1. 1.Environmental Carcinogenesis and ToxicologyChittaranjan National Cancer InstituteKolkataIndia
  2. 2.Department of Computer Science and Software EngineeringThe University of Western AustraliaPerthAustralia

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