Virus-Mediated Cancers in Animals
Ever since the discovery of the first tumour-associated virus in hen by Peyton Rous in 1911, cancer-causing viruses have been extensively investigated over the last century. Subsequently, tumour-associated viruses were discovered in several other animal species. Some of these are responsible for severe economic losses to farmers. Exposure to at least one animal virus has lately been reported to be related with cancer in humans. The ability of some of tumour viruses to cross species barrier and infect wild birds or animals to establish a natural reservoir of circulating virus, which can further evolve, may pose a major challenge to veterinary as well as human medicine. Animal tumour viruses have also been used as model system in their natural host as well as in laboratory animals to study the molecular basis of cellular tumorigenesis. This review attempts to summarize the important historical advances and some of the recent developments in the field of tumour viruses of animals with a focus on inter-species transmission.
KeywordsViral cancer Pathogenesis Animals Inter-species transmission
All the authors of the manuscript thank and acknowledge their respective universities and institutes.
Conflict of Interest
There is no conflict of interest.
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