Bovine Viral Diarrhea Virus

  • Niranjan Mishra
  • S. Kalaiyarasu


Bovine viral diarrhea (BVD) is prevalent worldwide and causes high economic losses in cattle due to a variety of disease syndromes. BVD is caused by three bovine pestiviruses, bovine viral diarrhea virus 1 (BVDV-1), BVDV-2 and HoBi-like pestivirus (HoBiPeV) with considerable genetic and antigenic heterogeneity. Bovine pestiviruses belong to the Pestivirus genus within the Flaviviridae family that also comprises the genera Flavivirus, Hepacivirus and Pegivirus. As per the latest (10th) ICTV report, pestiviruses have been classified into 11 approved species, including bovine pestiviruses, which have been classified into species, Pestivirus A, Pestivirus B and Pestivirus H. The term BVDV in this chapter commonly refers to all the three bovine pestiviruses. The pathogenesis of BVDV infection is complex, with infection pre- and post-gestation leading to different outcomes. BVDVs are highly successful to persist and spread in their host populations due to their unique ability to produce persistent infection through evasion of adaptive immune response and innate immune response. Recent advances in diagnostic methods, nucleotide sequencing, and computer-assisted phylogenetic analyses have so far identified 21 BVDV-1 subtypes (BVDV-1a to BVDV-1u), 4 BVDV-2 subtypes (BVDV-2a to BVDV-2d) and 4 HoBiPeV subtypes (HoBiPeV-a to HoBiPeV-d). Providing acquired immune protection against BVDV is challenging due to the antigenic diversity among BVDV strains and ability of BVDV to infect the fetus. Both killed and live attenuated vaccines have been reported to be effective in the field, and recent advancements in molecular studies have helped toward future development of new-generation vaccines against BVD. However, over the years, vaccination alone has not resulted in the elimination of BVDV-related clinical disease or a significant reduction in BVDV losses. All successful BVDV control programs are based on identification and removal of PI animals, movement controls, strict biosecurity and surveillance. To date, BVDV control programs without vaccination have been implemented successfully in Scandinavian countries, Austria and Switzerland, while control with vaccination has been used in Germany, Belgium, Ireland and Scotland. This chapter will focus on advances in research involving all aspects of BVDV with special emphasis on molecular biology, genetic and antigenic diversity, diagnosis, prevention and control besides discussion on future perspectives.


Pestivirus Bovine viral diarrhea virus Persistent infection BVDV-1 BVDV-2 HoBiPeV Epidemiology Diagnosis Control Cattle 



All the authors of the manuscript thank and acknowledge their respective institutes.

Conflict of Interest

There is no conflict of interest.


  1. Bachofen C, Stalder H, Braun U, Hilbe M, Ehrensperger F, Peterhans E (2008) Co-existence of genetically and antigenically diverse bovine viral diarrhoea viruses in an endemic situation. Vet Microbiol 131:93–102PubMedCrossRefGoogle Scholar
  2. Baker JC (1987) Bovine viral diarrhea virus: a review. J Am Vet Med Assoc 190:1449–1458PubMedGoogle Scholar
  3. Baker JC (1995) The clinical manifestation of bovine viral doarrhoea infection. Vet Clin N Am Food Anim Pract 11:425–445CrossRefGoogle Scholar
  4. Bauermann FV, Ridpath JF, Weiblen R, Flores EF (2013) HoBi-like viruses: an emerging group of pestiviruses. J Vet Diagn Investig 25:6–15CrossRefGoogle Scholar
  5. Baxi M, McRae D, Baxi S, Greiser-Wilke I, Vilcek S, Amoako K, Deregt D (2006) A one-step multiplex real time RT-PCR for detection and typing of bovine viral diarrhoea viruses. Vet Microbiol 116:37–44PubMedCrossRefGoogle Scholar
  6. Becher P, Tautz N (2011) RNA recombination in pestiviruses: cellular RNA sequences in viral genomes highlight the role of host factors for viral persistence and lethal disease. RNA Biol 8:216–224PubMedCrossRefGoogle Scholar
  7. Becher P, Orlich M, Kosmidon A, Konig M, Baroth M, Thiel HJ (1999) Genetic diversity of pestiviruses: identification of novel groups and implication for classification. Virology 262:64–71PubMedCrossRefPubMedCentralGoogle Scholar
  8. Becher P, Avalos Ramirez R, Orlich M, Cedillo Rosales S, Konig M, Schweizer M, Stalder H, Schirrmeier H, Thiel HJ (2003) Genetic and antigenic characterization of novel pestivirus genotypes: implications for classification. Virology 311:96–104PubMedCrossRefGoogle Scholar
  9. Behera SP, Mishra N, Vilcek S, Rajukumar K, Nema RK, Prakash A, Kalaiyarasu S, Dubey SC (2011) Genetic and antigenic characterization of bovine viral diarrhoea virus type 2 isolated from cattle in India. Comp Immunol Microbiol Infect Dis 34:189–196PubMedCrossRefPubMedCentralGoogle Scholar
  10. Bolin SR, Ridpath JF (1992) Differences in virulence between two noncytopathic bovine viral diarrhea viruses in calves. Am J Vet Res 53:2157–2163PubMedPubMedCentralGoogle Scholar
  11. Bolin SR, McClurkin AW, Cutlip RC, Coria MF (1985) Severe clinical disease induced in cattle persistently infected with noncytopathogenic bovine viral diarrhea virus by superinfection with cytopathogenic bovine viral diarrhea virus. Am J Vet Res 46:573–576PubMedPubMedCentralGoogle Scholar
  12. Brodersen BW, Kelling CL (1999) Alteration of leukocyte populations in calves concurrently infected with bovine respiratory syncytial virus and bovine viral diarrhea virus. Viral Immunol 12:323–334PubMedCrossRefPubMedCentralGoogle Scholar
  13. Brownlie J, Clarke MC, Howard CJ (1984) Experimental production of fatal mucosal disease in cattle. Vet Rec 114:535–536PubMedCrossRefPubMedCentralGoogle Scholar
  14. Brownlie J, Hooper LB, Thompson I, Collins ME (1998) Maternal recognition of foetal infection with bovine viral diarrhea virus (BVDV) – the bovine pestivirus. Clin Diag Virol 10:141–150CrossRefGoogle Scholar
  15. Callens N, Brügger B, Bonnafous P, Drobecq H, Gerl MJ, Krey T, Roman-Sosa G, Rümenapf T, Lambert O, Dubuisson J, Rouillé Y (2016) Morphology and molecular composition of purified bovine viral diarrhea virus envelope. PLoS Pathog 12:e1005476. Scholar
  16. Carman S, van Dreumel T, Ridpath J, Hazlett M, Alves D, Dubovi E, Tremblay R, Bolin S, Godkin A, Anderson N (1998) Severe acute bovine viral diarrhea in Ontario, 1993–1995. J Vet Diagn Investig 10:27–35PubMedCrossRefPubMedCentralGoogle Scholar
  17. Decaro N, Mari V, Pinto P, Lucente MS, Sciarretta R, Cirone F (2012) Hobi-like pestivirus: both biotypes isolated from a diseased animal. J Gen Virol 93:1976–1983PubMedCrossRefPubMedCentralGoogle Scholar
  18. Dias RK, Cargnelutti JF, Weber MN, Canal CW, Bauermann FV, Ridpath JF, Weiblen R, Flores EF (2017) Antigenic diversity of Brazilian isolates of HoBi-like pestiviruses. Vet Microbiol 203:221–228PubMedCrossRefPubMedCentralGoogle Scholar
  19. Donis RO, Corapi W, Dubovi EJ (1988) Neutralizing monoclonal antibodies to bovine viral diarrhoea virus bind to the 56K to 58K glycoprotein. J Gen Virol 69:77–86PubMedCrossRefPubMedCentralGoogle Scholar
  20. Dubovi EJ (2013) Laboratory diagnosis of bovine viral diarrhea virus. Biologicals 41:8–13PubMedCrossRefPubMedCentralGoogle Scholar
  21. Fulton RW, Ridpath JF, Confer AW, Saliki JT, Burge LJ, Payton ME (2003) Bovine viral diarrhoea virus antigenic diversity: impact on disease and vaccination programmes. Biologicals 31:89–95PubMedCrossRefPubMedCentralGoogle Scholar
  22. Giammarioli M, Ridpath JF, Rossi E, Bazzucchi M, Casciari C, De Mia GM (2015) Genetic detection and characterization of emerging HoBi-like viruses in archival foetal bovine serum batches. Biologicals 43:220–224PubMedCrossRefPubMedCentralGoogle Scholar
  23. Grassmann CW, Yu H, Isken O, Behrens SE (2005) Hepatitis C virus and the related bovine viral diarrhea virus considerably differ in the functional organization of the 5′ non-translated region: implications for the viral life cycle. Virology 333:349–366PubMedCrossRefPubMedCentralGoogle Scholar
  24. Grummer B, Grotha S, Greiser-Wilke I (2004) Bovine viral diarrhoea virus is internalized by clathrin-dependent receptor-mediated endocytosis. J Veterinary Med Ser B 51:427–432CrossRefGoogle Scholar
  25. Hoffmann B, Depner K, Schirrmeier H, Beer M (2006) A universal heterologous internal control system for duplex real-time RT-PCR assays used in a detection system for pestiviruses. J Virol Methods 136:200–209PubMedCrossRefPubMedCentralGoogle Scholar
  26. Horzinek M, Maess J, Laufs R (1971) Studies on the substructure of togaviruses. Arch Gesamte Virusforsch 33:306–318PubMedCrossRefPubMedCentralGoogle Scholar
  27. Houe H (1999) Epidemiological features and economical importance of bovine virus diarrhoea virus (BVDV) infections. Vet Microbiol 64:89–107PubMedCrossRefPubMedCentralGoogle Scholar
  28. Houe H (2003) Economic impact of BVDV infection in dairies. Biologicals 31:137–143PubMedCrossRefPubMedCentralGoogle Scholar
  29. Hulst MM, Moormann RJ (2001) Erns protein of pestiviruses. Methods Enzymol 342:431–440PubMedCrossRefPubMedCentralGoogle Scholar
  30. Jenckel M, Hoper D, Schirrmeier H, Reimann I, Goller KV, Hoffmann B, Beer M (2014) Mixed triple: allied viruses in unique recent isolates of highly virulent type 2 bovine viral diarrhea virus detected by deep sequencing. J Virol 88:6983–6992PubMedPubMedCentralCrossRefGoogle Scholar
  31. Kirkland PD, MacIntosh SG, Moyle A (1994) The outcome of widespread use of semen from a bull persistently infected with pestivirus. Vet Rec 135:527–529PubMedCrossRefGoogle Scholar
  32. Krey T, Thiel HJ, Rumenapf T (2005) Acid-resistant bovine pestivirus requires activation for pH-triggered fusion during entry. J Virol 79:4191–4200PubMedPubMedCentralCrossRefGoogle Scholar
  33. Kummerer BM, Meyers G (2000) Correlation between point mutations in NS2 and the viability and cytopathogenicity of bovine viral diarrhea virus strain Oregon analyzed with an infectious cDNA clone. J Virol 74:390–400PubMedPubMedCentralCrossRefGoogle Scholar
  34. Lackner T, Muller A, Pankraz A, Becher P, Thiel HJ, Gorbalenya AE (2004) Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus. J Virol 8:10765–10775CrossRefGoogle Scholar
  35. Lee KM, Gillespie JH (1957) Propagation of virus diarrhea virus of cattle in tissue culture. Am J Vet Res 18:952–953PubMedPubMedCentralGoogle Scholar
  36. Liang D, Sainz IF, Ansari IH, Gill LH, Vassilev V, Donis RO (2003) The envelope glycoprotein E2 is a determinant of cell culture tropism in ruminant pestiviruses. J Gen Virol 84:1269–1274PubMedCrossRefPubMedCentralGoogle Scholar
  37. Lindenbach BD, Murray CL, Thiel HJ, Rice CM (2013) Flaviviridae. In: Knipe DM, Howley PM (eds) Fields virology, vol 6. Lippincott Williams & Wilkins, Philadelphia, pp 712–746Google Scholar
  38. Liu L, Xia H, Belak S, Baule C (2008) A TaqMan real-time RT-PCR assay for selective detection of atypical bovine pestiviruses in clinical samples and biological products. J Virol Methods 154:82–85PubMedCrossRefPubMedCentralGoogle Scholar
  39. Liu L, Xia H, Wahlberg N, Belák S, Baule C (2009) Phylogeny, classification and evolutionary insights into pestiviruses. Virology 385:351–357PubMedCrossRefPubMedCentralGoogle Scholar
  40. Lokhandwala S, Fang X, Waghela SD, Bray J, Njongmeta LM, Herring A (2017) Priming cross-protective bovine viral diarrhea virus-specific immunity using live-vectored mosaic antigens. PLoS One 12(1):e0170425PubMedPubMedCentralCrossRefGoogle Scholar
  41. Malmquist WA (1968) Bovine viral diarrhea-mucosal disease: etiology, pathogenesis and applied immunity. J Am Vet Med Assoc 152:763–768Google Scholar
  42. Mathapati BS, Mishra N, Rajukumar K, Nema RK, Behera SP, Dubey SC (2010) Entry of bovine viral diarrhoea virus into ovine cells occurs through clathrin-dependent endocytosis and low pH-dependent fusion. In Vitro Cell Dev Biol Anim 46:403–407PubMedCrossRefGoogle Scholar
  43. Maurer K, Krey T, Moennig V, Thiel HJ, Rumenapf T (2004) CD46 is a cellular receptor for bovine viral diarrhea virus. J Virol 78:1792–1799PubMedPubMedCentralCrossRefGoogle Scholar
  44. McClurkin AW, Littledike ET, Cutlip RC, Frank GH, Coria MF, Bolin SR (1984) Production of cattle immunotolerant to bovine viral diarrhea virus. Can J Comp Med 48:156–161PubMedPubMedCentralGoogle Scholar
  45. McClurkin AW, Bolin SR, Coria MF (1985) Isolation of cytopathic and noncytopathic bovine viral diarrhea virus from the spleen of cattle acutely and chronically affected with bovine viral diarrhea. J Am Vet Med Assoc 186:568–569PubMedGoogle Scholar
  46. Meyers G, Thiel HJ (1996) Molecular characterization of pestiviruses. Adv Virus Res 47:53–118PubMedCrossRefGoogle Scholar
  47. Meyers G, Tautz N, Dubovi EJ, Thiel HJ (1991) Viral cytopathogenicity correlated with integration of ubiquitin-coding sequences. Virology 180:602–616PubMedCrossRefGoogle Scholar
  48. Meyers G, Ege A, Fetzer C, von Freyburg M, Elbers K, Carr V, Prentice H, Charleston B, Schurmann EM (2007) Bovine viral diarrhoea virus: prevention of persistent foetal infection by a combination of two mutations affecting the Erns RNase and the Npro protease. J Virol 81:3327–3338PubMedPubMedCentralCrossRefGoogle Scholar
  49. Mishra N, Pattnaik B, Vilcek S, Patil SS, Jain P, Swamy N, Bhatia S, Pradhan HK (2004) Genetic typing of bovine viral diarrhoea virus isolates from India. Vet Microbiol 104:207–212PubMedCrossRefGoogle Scholar
  50. Mishra N, Dubey R, Rajukumar K, Tosh C, Tiwari A, Pitale SS, Pradhan HK (2007a) Genetic and antigenic characterization of bovine viral diarrhea virus type 2 isolated from Indian goats (Capra hircus). Vet Microbiol 124:340–347PubMedCrossRefGoogle Scholar
  51. Mishra N, Dubey R, Galav V, Tosh C, Rajukumar K, Pitale SS, Pradhan HK (2007b) Identification of bovine viral diarrhea virus 1 in Indian buffaloes and their genetic relationship with cattle strains in 5’ UTR. Curr Sci 93:97–100Google Scholar
  52. Mishra N, Vilcek S, Rajukumar K, Dubey R, Tiwari A, Galav V, Pradhan HK (2008a) Identification of bovine viral diarrhea virus type 1 in yaks (Bos poepaghus grunniens) in Himalayan region. Res Vet Sci 84:507–510PubMedCrossRefGoogle Scholar
  53. Mishra N, Rajukumar K, Vilcek S, Tiwari A, Satav JS, Dubey SC (2008b) Molecular characterization of bovine viral diarrhea virus type 2 isolate originating from a native Indian sheep (Ovies aries). Vet Microbiol 130:88–98PubMedCrossRefGoogle Scholar
  54. Mishra N, Rajukumar K, Tiwari A, Nema RK, Behera SP, Satav JS, Dubey SC (2009) Prevalence of bovine viral diarrhoea virus antibodies among sheep and goats in India. Trop Anim Health Prod 41:1231–1239PubMedCrossRefGoogle Scholar
  55. Mishra N, Mathapati BS, Rajukumar K, Nema RK, Behera SP, Dubey SC (2010) Molecular characterization of RNA and protein synthesis during a one-step growth curve of bovine viral diarrhoea virus in ovine (SFT-R) cells. Res Vet Sci 89:130–132PubMedCrossRefGoogle Scholar
  56. Mishra N, Rajukumar K, Kalaiyarasu S, Dubey SC (2011) Pestivirus infection, an emerging threat to ruminants in India: a review. Indian J Anim Sci 81:545–551Google Scholar
  57. Mishra N, Pitale SS, Rajukumar K, Prakash A, Behera SP, Nema RK, Dubey SC (2012) Genetic variety of bovine viral diarrhoea virus 1 strains isolated from sheep and goats in India. Acta Virol 56:209–215PubMedCrossRefGoogle Scholar
  58. Mishra N, Rajukumar K, Pateriya A, Kumar M, Dubey P, Behera SP, Verma A, Bhardwaj P, Kulkarni DD, Vijaykrishna D, Reddy ND (2014) Identification and molecular characterization of novel and divergent HoBi-like pestiviruses from naturally infected cattle in India. Vet Microbiol 174:239–246PubMedCrossRefGoogle Scholar
  59. Mishra N, Kalaiyarasu S, Mallinath KC, Rajukumar K, Khetan RK, Gautam S, Venkatesha MD, Byregowda SM (2018) Identification of bovine viral diarrhoea virus type 2 (BVDV-2) in cattle bull semen from southern India and its genetic characterization. Curr Sci 114:666–670CrossRefGoogle Scholar
  60. Moennig V, Becher P (2018) Control of bovine viral diarrhea. Pathogens 7:29PubMedCentralCrossRefPubMedGoogle Scholar
  61. Moennig V, Houe H, Lindberg A (2005) BVD control in Europe: current status and perspectives. Anim Health Res Rev 6:63–74PubMedCrossRefGoogle Scholar
  62. Nagai M, Hayashi M, Itou M, Fukutomi T, Akashi H, Kida H, Sakoda Y (2008) Identification of new genetic subtypes of bovine viral diarrhea virus genotype 1 isolated in Japan. Virus Genes 36:135–139PubMedCrossRefGoogle Scholar
  63. Nayak BC, Panda SN, Misra DB, Kar BC, Das BC (1981) Note on serological evidence of viral abortion in cattle in Orissa. Indian J Anim Sci 52:102–103Google Scholar
  64. Newcomer BW, Neill JD, Marley MS, Ridpath JF, Givens MD (2013) Mutations induced in the NS5B gene of bovine viral diarrhea virus by antiviral treatment convey resistance to the compound. Virus Res 174:95–100PubMedCrossRefGoogle Scholar
  65. Niskanen R, Lindberg A (2003) Transmission of bovine viral diarrhoea virus by unhygienic vaccination procedures, ambient air, and from contaminated pens. Vet J 165:125–130PubMedCrossRefGoogle Scholar
  66. OIE (2017) Manual of diagnostic tests and vaccines for terrestrial animals. Chapter 2.4.7, Bovine viral diarrhea. OIE, Paris, pp 1–22Google Scholar
  67. Olafson P, McCallum AD, Fox FH (1946) An apparently new transmissible disease of cattle. Cornell Vet 36:205–213PubMedGoogle Scholar
  68. Paton DJ, Sands JJ, Lowings JP, Smith JE, Ibata G, Edwards S (1995) A proposed division of the pestivirus genus using monoclonal antibodies, supported by cross-neutralization assays and genetic sequencing. Vet Res 26:92–109PubMedGoogle Scholar
  69. Pellerin C, Van den Hurk J, Lecomte J, Tijssen P (1994) Identification of a new group of bovine viral diarrhea virus strains associated with severe outbreaks and high mortality. Virology 203:260–268PubMedCrossRefGoogle Scholar
  70. Perdrizet JA, Rebhun WC, Dubovi EJ, Donis RO (1987) Bovine virus diarrhea-clinical syndromes in dairy herds. Cornell Vet 77:46–74PubMedGoogle Scholar
  71. Pestova TV, de Breyne S, Pisarev AV, Abaeva IS, Hellen CU (2008) eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II. EMBO J 27:1060–1072PubMedPubMedCentralCrossRefGoogle Scholar
  72. Pizarro-Lucero J, Celedon MO, Aguilera M, de Calisto A (2006) Molecular characterization of pestiviruses isolated from bovines in Chile. Vet Microbiol 115:208–217PubMedCrossRefGoogle Scholar
  73. Platt R, Kesl L, Guidarini C, Wang C, Roth JA (2017) Comparison of humoral and T-cell-mediated immune responses to a single dose of Bovela live double deleted BVDV vaccine or to a field BVDV strain. Vet Immunol Immunopathol 187:20–27PubMedCrossRefGoogle Scholar
  74. Poole TL, Wang CY, Popp RA, Potgieter LND, Siddiqui A, Collett MS (1995) Pestivirus translation initiation occurs by internal ribosome entry. Virology 206:750–754PubMedCrossRefGoogle Scholar
  75. Ramsey FK, Chivers WH (1953) Mucosal disease of cattle. North Am Vet 34:629–633Google Scholar
  76. Rawlings ND, Barrett AJ, Bateman A (2012) MEROPS: The database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res 40:D343–D350PubMedPubMedCentralCrossRefGoogle Scholar
  77. Reber AJ, Tanner M, Okinaga T, Woolums AR, Williams S, Ensley DT, Hurley DJ (2006) Evaluation of multiple immune parameters after vaccination with modified live or killed bovine viral diarrhea virus vaccines. Comp Immunol Microbiol Infect Dis 29:61–77PubMedCrossRefGoogle Scholar
  78. Richter V, Lebi K, Baumgartner W, Obritzhauser W, Käsbohrer A, Pinior B (2017) A systematic worldwide review of the direct monetary losses in cattle due to bovine viral diarrhoea virus infection. Vet J 220:80–87PubMedCrossRefGoogle Scholar
  79. Ridpath JF (2013) Immunology of BVDV vaccines. Biologicals 41:14–19PubMedCrossRefGoogle Scholar
  80. Ridpath J, Bolin SR, Dubovi EJ (1994) Segregation of bovine viral diarrhea virus into genotypes. Virology 205:66–74PubMedCrossRefPubMedCentralGoogle Scholar
  81. Ridpath JF, Neill JD, Frey M, Landgraf JG (2000) Phylogenetic, antigenic and clinical characterization of type 2 BVDV from North America. Vet Microbiol 77:145–155PubMedCrossRefPubMedCentralGoogle Scholar
  82. Ridpath JF, Fulton RW, Kirkland PD, Neill JD (2010) Prevalence and antigenic differences observed between bovine viral diarrhea virus subgenotypes isolated from cattle in Australia and feedlots in the southwestern United States. J Vet Diagn Investig 22:184–191CrossRefGoogle Scholar
  83. Ronecker S, Zimmer G, Herrler G, Greiser-Wilke I, Grummer B (2008) Formation of bovine viral diarrhea virus E1-E2 heterodimers is essential for virus entry and depends on charged residues in the transmembrane domains. J Gen Virol 89:2114–2121PubMedCrossRefPubMedCentralGoogle Scholar
  84. Rumenapf T, Unger G, Strauss JH, Thiel HJ (1993) Processing of the envelope glycoproteins of pestiviruses. J Virol 67:3288–3294PubMedPubMedCentralGoogle Scholar
  85. Schirrmeier H, Strebelow G, Depner K, Hoffmann B, Beer M (2004) Genetic and antigenic characterization of an atypical pestivirus isolate, a putative member of a novel pestivirus species. J Gen Virol 85:3647–3652PubMedCrossRefPubMedCentralGoogle Scholar
  86. Schmeiser S, Mast J, Thiel HJ, Konig M (2014) Morphogenesis of pestiviruses: new insights from ultrastructural studies of strain Giraffe-1. J Virol 88:2717–2724PubMedPubMedCentralCrossRefGoogle Scholar
  87. Simmonds P, Becher P, Collett MS, Gould EA, Heinz FX, Meyers G (2012) Flaviviridae In: King AMQ, Lefkowitz E, Adams MJ, Carstens EB, Fauquet CM (eds) Ninth report of the international committee on taxonomy of viruses. Academic Press, San Diego, pp 1003–1020Google Scholar
  88. Singh V, Mishra N, Kalaiyarasu S, Khetan RK, Hemadri D, Singh RK, Rajukumar K, Chamuah J, Suresh KP, Patil SS, Singh VP (2017) First report on serological evidence of bovine viral diarrhea virus (BVDV) infection in farmed and free ranging mithuns (Bos frontalis). Trop Anim Health Prod 49:1149–1156PubMedCrossRefPubMedCentralGoogle Scholar
  89. Smith DB, Meyers G, Bukh J, Gould EA, Monath T, Muerhoff AS, Pletnev A, Rico-Hesse R, Stapleton JT, Simmonds P, Becher P (2017) Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae. J Gen Virol 98:2106–2112PubMedPubMedCentralCrossRefGoogle Scholar
  90. Stark R, Meyers G, Rumenapf T, Thiel HJ (1993) Processing of pestivirus polyprotein: cleavage site between autoprotease and nucleocapsid protein of classical swine fever virus. Virol 67:7088–7095Google Scholar
  91. Sudharsana KJ, Suresh KB, Rajasekhar M (1999) Prevalence of bovine viral diarrhea virus antibodies in India. Rev Sci Tech 18:667–671CrossRefGoogle Scholar
  92. Tautz N, Meyers G, Thiel HJ (1993) Processing of poly-ubiquitin in the polyprotein of an RNA virus. Virology 197:74–85PubMedCrossRefPubMedCentralGoogle Scholar
  93. Tautz N, Meyers G, Stark R, Dubovi EJ, Thiel HJ (1996) Cytopathogenicity of a pestivirus correlated with a 27 nucleotide insertion. J Virol 70:7851–7858PubMedPubMedCentralGoogle Scholar
  94. Underdahl NR, Grace OD, Hoerlein AB (1957) Cultivation in tissue-culture of cytopathogenic agent from bovine mucosal disease. Proc Soc Exp Biol Med 94:795–797PubMedCrossRefPubMedCentralGoogle Scholar
  95. Van Campen H, Frolich K (2001) Pestivirus infections In: Williams ES, Barker IK (eds) Infectious diseases of wild mammals. Iowa State University Press, Iowa City, pp 232–244Google Scholar
  96. Vilcek S, Nettleton PF (2006) Pestiviruses in wild animals. Vet Microbiol 116:1–12PubMedCrossRefPubMedCentralGoogle Scholar
  97. Vilcek S, Paton DJ, Durkovic B, Strojny L, Ibata G, Moussa A, Loitsch A, Rossmanith W, Vega S, Scicluna MT, Palfi V (2001) Bovine viral diarrhea virus genotype 1 can be separated into at least eleven genetic groups. Arch Virol 146:99–115PubMedCrossRefPubMedCentralGoogle Scholar
  98. Vilcek S, Durkovic B, Kolesarova M, Greiser-Wilke I, Paton DJ (2004) Genetic diversity of international bovine viral diarrhoea virus (BVDV) isolates: identification of a new BVDV-1 genetic group. Vet Res 35:609–615PubMedCrossRefPubMedCentralGoogle Scholar
  99. Vilček Š, Ridpath JF, Van Campen H, Cavender JL, Warg J (2005) Characterization of a novel pestivirus originating from a pronghorn antelope. Virus Res 108:187–193PubMedCrossRefPubMedCentralGoogle Scholar
  100. Walz PH, Bell TG, Wells JL, Grooms DL, Kaiser L, Maes RK, Baker JC (2001) Relationship between degree of viremia and disease manifestation in calves with experimentally induced bovine viral diarrhea virus infection. Am J Vet Res 62:1095–1103PubMedCrossRefPubMedCentralGoogle Scholar
  101. Warrilow D, Lott WB, Greive S, Gowans EJ (2000) Properties of the bovine viral diarrhoea virus replicase in extracts of infected MDBK cells. Arch Virol 145:2163–2171PubMedCrossRefPubMedCentralGoogle Scholar
  102. Weber MN, Streck AF, Silveira S, Mósena AC, Silva MS, Canal CW (2015) Homologous recombination in pestiviruses: identification of three putative novel events between different subtypes/genogroups. Infect Genet Evol 30:219–224PubMedCrossRefPubMedCentralGoogle Scholar
  103. Weiland E, Stark R, Haas B, Rumenapf T, Meyers G, Thiel HJ (1990) Pestivirus glycoprotein which induces neutralizing antibodies forms part of a disulfide linked heterodimer. J Virol 64:3563–3569PubMedPubMedCentralGoogle Scholar
  104. Willoughby K, Valdazo-Gonzalez B, Maley M, Gilray J, Nettleton PF (2006) Development of a real time RT-PCR to detect and type ovine pestiviruses. J Virol Methods 132:187–194PubMedCrossRefPubMedCentralGoogle Scholar
  105. Yadav P, Barde PV, Jadi R, Gokhale MD, Basu A, Joshi MV, Mehla R, Kumar SR, Athavale SS, Mourya DT (2004) Isolation of bovine viral diarrhea virus 1, a pestivirus from autopsied lamb specimen from Tamil Nadu, India. Acta Virol 48:223–227PubMedPubMedCentralGoogle Scholar
  106. Yarnall MJ, Thrusfield MV (2017) Engaging veterinarians and farmers in eradicating bovine viral diarrhoea: a systematic review of economic impact. Vet Rec 181:347. Scholar
  107. Yesilbag K, Forster C, Bank-Wolf B, Yilmaz Z, Alkan F, Ozkul FA, Burgu I, Rosales SC, Theil HJ, Konig M (2008) Genetic heterogeneity of bovine viral diarrhoea virus (BVDV) isolates from Turkey: identification of a new subgroup in BVDV-1. Vet Microbiol 130:258–267CrossRefGoogle Scholar
  108. Yesilbag K, Forster C, Ozyigit MO, Alpay G, Tuncer P, Theil HJ, Konig M (2014) Characterisation of bovine viral diarrhoea virus (BVDV) isolates from an outbreak with haemorrhagic enteritis and severe pneumonia. Vet Microbiol 169:42–49PubMedCrossRefPubMedCentralGoogle Scholar
  109. Yesilbag K, Alpay G, Becher P (2017) Variability and global distribution of subgenotypes of bovine viral diarrhea virus. Viruses 9:128. Scholar
  110. Zogg T, Sponring M, Schindler S, Koll M, Schneider R, Brandstetter H, Auer B (2013) Crystal structures of the viral protease Npro imply distinct roles for the catalytic water in catalysis. Structure 21:929–938PubMedPubMedCentralCrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Niranjan Mishra
    • 1
  • S. Kalaiyarasu
    • 1
  1. 1.Indian Council of Agricultural Research-National Institute of High Security Animal DiseasesBhopalIndia

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