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Mitochondria and Renal Fibrosis

  • Mohammed Mazheruddin Quadri
  • Syeda-Safoorah Fatima
  • Ruo-Chen Che
  • Ai-Hua ZhangEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1165)

Abstract

Mitochondria are important organelles in eukaryotic cells and perform a variety of biosynthetic and metabolic functions. Many human diseases are closely related to mitochondrial dysfunction. Kidney is an organ with high-energy requirements, which is distributed with a large number of mitochondria. Mitochondrial dysfunction plays a crucial role in the pathogenesis of kidney disease, and studies have shown that mitochondrial dysfunction is involved in the physiological process of renal fibrosis. This review introduced the biogenesis and pathophysiology of mitochondria, illustrated the involvement of mitochondrial dysfunction in renal fibrosis based on various kinds of cells, and finally summarized the latest mitochondria-targeted therapies.

Keywords

Mitochondria Renal fibrosis Therapies 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Mohammed Mazheruddin Quadri
    • 1
  • Syeda-Safoorah Fatima
    • 1
  • Ruo-Chen Che
    • 1
  • Ai-Hua Zhang
    • 1
    Email author
  1. 1.Department of NephrologyChildren’s Hospital of Nanjing Medical UniversityNanjingChina

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