Aptamers pp 133-154 | Cite as

Aptasensor-Possible Design and Strategy for Aptamer Based Sensor

  • Jyoti Yadav
  • Ankush
  • Khushboo
  • Mony Thakur
  • Karuna Yadav
  • Manisha Sharma
  • Kashyap Kumar Dubey


Aptamers have procured immense attention as an evident identification element in biosensor design. Presently various electrochemical, optical, colorimetric, fluorescent, luminescent etc. are in trend because of their small size, flexibility to design, high sensitivity, high selectivity, chemical stability, temperature resistibility and cost effectiveness. The aptasensors have been classified in various groups depending on their configuration, confirmation and conductivity and four basic strategies have been used for designing the aptasensors i.e. target induced structure mode, sandwich mode, target induced dissociation mode and competitive replacement mode turning on the specific bidding process leading to signal variation however certain efforts have been made continuously in the design and operation of aptasensors. Nanotechnology, micromachines, quantum dot etc. have paved a new way in improvement of biosensors however in spite of rapid advancement aptasensors are still immature and need further amelioration.

Researchers are on way to take the tools further for significant advancement in the performance of aptasensors because of their unprecedented advantages. This chapter will give an overview of different types of aptasensors with their designing strategies and methods that have been implemented so far.


Aptamer designing Target induced modes Aptamer types 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Jyoti Yadav
    • 1
  • Ankush
    • 2
  • Khushboo
    • 2
  • Mony Thakur
    • 1
  • Karuna Yadav
    • 2
  • Manisha Sharma
    • 2
  • Kashyap Kumar Dubey
    • 2
  1. 1.Department of MicrobiologyCentral University of HaryanaMahendergarhIndia
  2. 2.Department of BiotechnologyCentral University of HaryanaMahendergarhIndia

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