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Role of ROS in T. cruzi Intracellular Development

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Oxidative Stress in Microbial Diseases

Abstract

Chagas disease, caused by the protozoan Trypanosoma cruzi, presents a variable clinical course ranging from asymptomatic cases to more severe forms with cardiac, digestive, or cardio-digestive impairment. The factors involved in this clinical heterogeneity are not completely understood, but certainly both host and parasite genetic variability are important in this process. In the vertebrate host, the establishment of the infection depends on parasite host cell invasion and intracellular multiplication, as well as the host immune response to parasite colonization. T. cruzi is able to invade different cell types, but macrophages as a first defense cell and muscle cells (specially cardiomyocytes) are considered key during the establishment of infection in the host. Many factors regulate parasite invasion and intracellular development. Reactive oxygen species (ROS) have been shown to be important during parasite host cell infection. Although in many cases ROS is seen as detrimental to parasite development, recent evidences from the literature have shown that ROS may actually have a dual role during infection. While in some circumstances it could work in parasite control, in other scenarios, it may act to potentiate parasite intracellular multiplication. Here, we present a brief background of the disease and parasite genetic structure in order to discuss this dual role of ROS during parasite host cell colonization.

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Authors and Affiliations

  1. Departamento de Morfologia, Universidade Federal de Minas Gerais, Minas Gerais, Brazil

    Luciana O. Andrade & Patrícia Pereira Dias

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  1. Luciana O. Andrade
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  2. Patrícia Pereira Dias
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Correspondence to Luciana O. Andrade .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Amity University, Kolkata, West Bengal, India

    Dhrubajyoti Chattopadhyay

  4. National Institute of Immunology, New Delhi, India

    Chandrima Shaha

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Andrade, L.O., Dias, P.P. (2019). Role of ROS in T. cruzi Intracellular Development. In: Chakraborti, S., Chakraborti, T., Chattopadhyay, D., Shaha, C. (eds) Oxidative Stress in Microbial Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8763-0_5

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