Acute Posterior Multifocal Placoid Pigment Epitheliopathy
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare inflammatory eye disease affecting the outer retina, retinal pigment epithelium (RPE), and choriocapillaris in mostly otherwise healthy adults between the ages of 20 and 50 years. It shows no clear gender preference. APMPPE was first described by Gass in 1968 in a series of three young female patients who presented with multiple large plaque-like lesions at the level of the RPE associated with temporary bilateral visual loss (Gass 1968). APMPPE is considered one of the “placoid diseases” together with serpiginous choroiditis (SC), relentless placoid chorioretinitis, and persistent placoid maculopathy due to the “placoid” nature of the lesions and similarities on fluorescein angiography (FA) and indocyanine green angiography (ICGA) findings (Mirza and Jampol 2012).