Post-transcriptional Gene Silencing as a Tool for Controlling Viruses in Plants

  • Nikolay M. PetrovEmail author
  • Mariya I. Stoyanova
  • R. K. Gaur


RNA gene silencing is a mechanism for gene regulation, which limits transcription level by suppression of transcription (transcriptional gene silencing, TGS) or by activation of a process of degradation of specific RNA sequence (post-transcriptional gene silencing, PTGS), known also as RNA interference (RNAi). RNA interference was observed for the first time by chance during 1990, when in an attempt for over-expression of the chalcone synthase gene in petunias by insertion of its chimeric duplicate, the result was just the opposite – blocking of anthocyanin biosynthesis. After 16 years of experiments, the significance of this phenomenon has grown so much, that a Nobel Prize was awarded to Fire and Mello for its discovery. This chapter presents a retrospection of RNA gene silencing, its mechanism of action, corresponding participants, role in plants, and possible applications with a focus on the perspectives for utilizing this mechanism as a tool for control of viruses in plants.


RNA interference RNA gene silencing Post-transcriptional gene silencing PTGS RNAi Classes of RNAs Virus control 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Nikolay M. Petrov
    • 1
    Email author
  • Mariya I. Stoyanova
    • 2
  • R. K. Gaur
    • 3
  1. 1.New Bulgarian UniversitySofiaBulgaria
  2. 2.Institute of Soil ScienceAgrotechnologies and Plant Protection “N. Pushkarov”SofiaBulgaria
  3. 3.Department of BiotechnologyDeen Dayal Upadhyaya Gorakhpur UniversityGorakhpurIndia

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