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Use of Short-Term Inhalation Study to Obtain Initial Hazard Data and Prepare for Subacute and Subchronic Inhalation Studies, and Toxicokinetic Studies

  • Ki Soo Jeon
  • Jae Seong Yi
  • Il Je YuEmail author
Chapter
Part of the Current Topics in Environmental Health and Preventive Medicine book series (CTEHPM)

Abstract

A short-term inhalation study (STIS) protocol that has been specifically developed for testing nanomaterials can be used as an alternative testing choice for acute toxicity testing, and a range-finding study for subacute and subchronic studies. The STIS can also be used to characterize the nanoparticle physicochemical properties and determine the type of exposure and particle monitoring methods in the inhalation chamber for subsequent subacute and subchronic inhalation studies. In addition, importantly, the particle generation method and particle concentration stability can be studied before and during the STIS. Furthermore, combining an STIS with a lung burden analysis, which is now a mandatory requirement for OECD 412 (subacute) and 413 (subchronic) test guidelines, can provide toxicokinetic information, including the biodistribution and lung clearance of nanoparticles.

Keywords

Short-term inhalation study Inhalation toxicity Toxicokinetics Nanomaterials Nanoparticles 

Notes

Acknowledgement

This research was supported by the Industrial Technology Innovation Program (10052901), Development of highly usable nanomaterial inhalation toxicity testing system in commerce through the Korea Evaluation Institute of Industrial Technology by the Korean Ministry of Trade, Industry & Energy

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.HCTm Co. Ltd.IcheonRepublic of Korea

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