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Taurine 11 pp 101-112 | Cite as

Taurine Supplementation Inhibits Cardiac and Systemic Renin-Angiotensin System Overactivity After Cardiac Ischemia/Reperfusion in Adult Female Rats Perinatally Depleted of Taurine Followed by High Sugar Intake

  • Supaporn Kulthinee
  • James Michael Wyss
  • Sanya RoysommutiEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Perinatal taurine depletion and high sugar intake from weaning onward worsen cardiac damage and arterial pressure control after ischemia/reperfusion (IR) in adult male and female rats, which can be ameliorated by high taurine diets or inhibition of renin-angiotensin system. This study tests if taurine supplementation ameliorates cardiac damage and arterial pressure control in adult female rats via alterations of both cardiac and systemic renin-angiotensin system. Female Sprague-Dawley rats were fed normal rat chow and drank water alone (control, C) or water containing 3% beta-alanine (taurine depletion, TD) from conception to weaning, and female offspring were subjected to high sugar intake (normal rat chow and 5% glucose in water; CG and TDG) or the normal rat diet (CW and TDW). At 7 weeks of age, half of the rats in each group received 3% taurine in water (CW+T, CG+T, TDW+T, and TDG+T). One week later, rats were subjected to IR or Sham procedures followed by renal nerve recording, plasma and cardiac angiotensin II measurements. Cardiac angiotensin II levels significantly elevated in CG, TDW, and TDG. Further, plasma angiotensin II concentrations were significantly elevated only in the TDG, in consistent with a significant increase in renal nerve activity to juxtaglomerular cells, but not renal vessels and tubules. These abnormalities were ameliorated by short-term taurine supplementation. Thus, in adult female rats that are perinatally depleted of taurine followed by high sugar intake after weaning, taurine supplementation decreases the adverse effects of cardiac IR via inhibition of both cardiac and systemic renin-angiotensin system overactivity.

Keywords

Angiotensin II Arterial pressure control Cardiac injury High sugar intake Perinatal taurine depletion Taurine supplementation Sympathetic activity 

Abbreviations

IR

ischemia/reperfusion

Sham

normal rats without cardiac ischemia/reperfusion induction

CW

control with water intake alone

CW+T

control with water intake alone plus taurine

CG

control with high sugar intake

CG+T

control with high sugar intake plus taurine

TDW

perinatal taurine depletion with water intake alone

TDW+T

perinatal taurine depletion with water intake alone plus taurine

TDG

perinatal taurine depletion with high sugar intake

TDG+T

perinatal taurine depletion with high sugar intake plus taurine

Notes

Acknowledgements

This study was supported by grants from Faculty of Medicine and Graduate School, Khon Kaen University, Khon Kaen 40002, Thailand.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Supaporn Kulthinee
    • 1
    • 2
  • James Michael Wyss
    • 3
  • Sanya Roysommuti
    • 1
    Email author
  1. 1.Department of Physiology, Faculty of MedicineKhon Kaen UniversityKhon KaenThailand
  2. 2.Chulabhorn International College of MedicineThammasat UniversityPathumthaniThailand
  3. 3.Department of Cell, Developmental and Integrative Biology, School of MedicineUniversity of Alabama at BirminghamBirminghamUSA

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