Effects of Taurine on Bowel Inflammatory Factor of Small Intestinal Mucosa Impaired by Heat Stress in Broilers
This study investigated the effects of taurine on bowel inflammation resulting from heat stress in broilers, with the intent of providing insight into potential improvement of the condition of broilers. A total of 300 healthy 1 day AA broilers were selected, fed normally until day 7, and allocated randomly to 5 treatment groups, namely, the control group(C), the heat stress group(HS), the low Tau (LTau) group, the middle Tau (MTau) group and the high Tau (HTau) group, which represent low, medium and high concentrations of taurine respectively. In the study, various concentrations of taurine were added to the drinking water. The Heat Stress model was produced by maintaining Broilers in a room at 34 °C.Heat stress persisted for 6 h, 12 h, 7 days, and 14 days. The results showed that the expression levels of TNF-α, IFN-γ, and IL-1β of the HTau group were significantly lower than that of the HS group at all time points examined (6 h, 12 h, 7 days, and 14 days) (P < 0.05). Compared with the HS group subjected to 6 h, 12 h and 14 days of heat stress, the MTau group exhibited significantly lower degrees of TNF-α and IL-1β expression. Moreover, the expression of IFN-γ was higher in the HS group after 6 h, 12 h and 7 days of heat stress than that of the MTau group subjected to similar times of heat stress (P < 0.05).There were no significant difference among the groups at other periods of heat stress (P > 0.05).
KeywordsTaurine Bowel inflammation Heat stress Broilers
The project was supported by the National Key Program for Research and Development (2017YFD0500503), Rural public relations and industrialization of achievements in science and technology program in Liaoning province (2014211003).
- Bai Xiaoqiong, Kong Deyi (2011) Progress in taurine research [J]. Chin Food Nutr 17(5):78–80Google Scholar
- Chen Yuzhen (1994) Physiological function of taurine and its application [J]. J Prev Med PLA (4):329–332Google Scholar
- He Shasha (2016) Protective effect and mechanism of ferulic acid on intestinal mucosal barrier injury in heat stress rats [D]. Agricultural University of ChinaGoogle Scholar
- Huang Jing, Wu Jun, Sun Yang et al (2016) Taurine inhibits inflammatory pain and its mechanism in rats [J]. Chi Mod Drug Appl 10(14):283–284Google Scholar
- Li Juan (2014) TNF-α and IFN-γ regulate the inflammatory response of mouse enteritis induced by DSS by activating the NF-κ B/STAT3 pathway of bone marrow mesenchymal stem cells [D]. Xiamen UniversityGoogle Scholar
- Liu Xing (2011) The role of HIF-1 α in intestinal epithelial barrier dysfunction induced by IFN-γ and TNF-α [D]. Third military Medical UniversityGoogle Scholar
- Lu Ping, Gao Shirong (2015) The role of TNF-α and interleukin in the pathogenesis of inflammatory bowel disease in children [J]. J Appl Clin Med 19(17):192–193Google Scholar
- Sun Ruiyuan, Lu Qiufeng (2016) Taurine and stress-induced hypertension [J]. Adv Anim Med 37(10):111–115Google Scholar
- Wu Xiaolan, Zhao Shufen (2004) Progress in the study of the mechanism of IL-1 β heat [J]. Adv Anat Sci 10(3):267–270Google Scholar
- Wu Zhenming (2017) Protective effect of taurine on heat stress in broilers [D]. Shenyang Agricultural UniversityGoogle Scholar
- Xu Ling, Wang Qing Zheng, Du Xiaogui et al (2015) Antioxidation mechanism of taurine and its application in young animals [J]. J Animal Nutrition 27(12):3683–3688Google Scholar
- Yang Songwei (2014) Mechanism of NF-κ B/HIF-1 α pathway in IFN-γ -induced intestinal epithelial barrier damage [D]. Third military Medical UniversityGoogle Scholar